Matching Items (4)
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- All Subjects: Cortisol
- All Subjects: ICSS
- Creators: Presson, Clark
Description
In recent years the abuse of synthetic cathinones, "Bath Salts," has increased. The purpose of this study was to analyze two synthetic cathinones, methylone and α-pvp, for hedonic properties or the potential to be abused. This was tested using an intracranial self-stimulation paradigm, a robust measurement for reward. It was found methylone resulted in an abuse potential similar to MDMA, ecstasy, abuse. Moreover, the results for α-pvp showed a high liability for abuse.
ContributorsJohnson, Craig Trevor (Author) / Olive, Foster (Thesis director) / Presson, Clark (Committee member) / Montesano, Mark (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor) / Department of Psychology (Contributor)
Created2013-12
Description
Although discrimination is implicated in ethnic health disparities, social support may buffer against its negative effects on health. This study investigated whether prenatal maternal discrimination and social support would predict postpartum cortisol in low-income Hispanic women and infants. Among infants whose mothers reported high discrimination, low maternal social support was associated with high infant cortisol (ß= -0.293, p= 0.03). This provides evidence for the social buffering hypothesis.
ContributorsJewell, Shannon Linda (Author) / Luecken, Linda (Thesis director) / Presson, Clark (Committee member) / Gonzales, Nancy (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor)
Created2013-05
Description
The use of synthetic cathinones or "bath salts" has risen dramatically in recent years with one of the most popular being Methylendioxypyrovalerone (MDPV). Following the temporary legislative ban on the sale and distribution of this compound , a multitude of other cathinone derivatives have been synthesized. The current study seeks to compare the abuse potential of MDPV with one of the emergent synthetic cathinones 4-methylethcathinone (4-MEC), based on their respective ability to lower current thresholds in an intracranial self-stimulation (ICSS) paradigm. Following acute administration (0.1, 0.5, 1 and 2 mg/kg i.p.) MDPV was found to significantly lower ICSS thresholds at all doses tested (F4,35=11.549, p<0.001). However, following acute administration (0.3,1,3,10,30 mg/kg i.p) 4-MEC produced no significant ICSS threshold depression (F5,135= 0.622, p = 0.684). Together these findings suggest that while MDPV may possess significant abuse potential, other synthetic cathinones such as 4-MEC may have a drastically reduced potential for abuse.
ContributorsWegner, Scott Andrew (Author) / Olive, M. Foster (Thesis director) / Presson, Clark (Committee member) / Sanabria, Federico (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Department of Psychology (Contributor)
Created2013-05
Description
Family influences are known predictors of adolescent health and well-being trajectories, yet little research has investigated how adolescents’ orientation to family may be associated with their physiological stress responses. Influenced by the strength-based approach to culture, this study evaluated 418 Hispanic adolescents' familism values and perceived life stress in family, school, and peer domains to investigate prospective associations with hypothalamic-pituitary-adrenal axis stress responses to the Group Public Speaking Task for Adolescents (GPST-A). Prior growth-mixture modeling on this sample revealed a five-class solution of cortisol responding to the GPST-A that was used here as the dependent variable: one class showed a more pronounced pattern of reactivity, potentially indicative of hyper-responsivity to the stress task; two classes showed evidence of a low to moderate cortisol response, potentially indicative of an adaptive physiological response to the challenge; and two classes showed patterns of non-responsivity, potentially indicative of hypo-responsivity. Results demonstrate that the role of familism is nuanced in the context of stressors, potentially offering both promotive and risk-amplifying effects for the physiological stress response system. This study offered several novel findings in the relation between cultural factors, salient stressors of adolescence, and HPA activity.
ContributorsSmola, Xochitl Arlene (Author) / Gonzales, Nancy (Thesis director) / Presson, Clark (Committee member) / Doane, Leah (Committee member) / Department of Psychology (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05