Matching Items (9)
Filtering by
- All Subjects: medicine
- Creators: School of Historical, Philosophical and Religious Studies
- Status: Published
Description
Human subject research is a sensitive ethical topic in today's society, and with good cause. The history of human subject research is full of tragedy and wrongdoing, which is what has led to the firm restrictions we presently have. At the same time, we also acknowledge the value behind human subject research and the information science can obtain from such endeavors. This project analyzes this conundrum through a narrative describing a group of scientists who choose to ignore some of the laws and regulations concerning human subject research in order to pursue neurological based research for a "greater good." In the novella, the scientists end up harming several people while performing their illegal research, but are able to obtain successful results. However, the group is eventually caught, and end up having to face the consequences of their actions. The situations and interactions the story presents are meant to juxtapose both sides of the human subject research ethical argument in a unique way in order to allow the reader to critically think through the argument themselves and form their own opinions on the matter.
ContributorsPirotte, Benjamin Daniel (Author) / Finn, Edward (Thesis director) / Cook, Paul (Committee member) / McGregor, Joan (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2015-05
Description
This project looks at ways in which the individual comes into contact with history. By looking at the Katyń Massacre, we can see how violence and history can be viewed from aesthetic perspectives. This allows us to take part in the conversations concerned with genocide in other ways than from ethical and sympathetic perspectives. By examining the Katyń through an aesthetic lens, the individual can approach violence in new and unique ways. This research highlights for us a new way of approaching history and violence while simultaneously offering a way for the individual to have a new voice in history. The poetry that follows the research offers a way for us to aestheticize violence and use language to approach it in a way that is simultaneously cruel and beautiful.
ContributorsTucker, Robert Charles Austin (Author) / Sarah, Ball (Thesis director) / Castle, Gregory (Committee member) / Barrett, The Honors College (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / Department of English (Contributor)
Created2015-05
Description
The unprecedented rise of terrorist network ISIL has brought the revolutionary Salafi agenda to the forefront of global politics. This thesis provides an analysis of the ideology and an overview of ISIL. The research is comprised of reports on the organization from prominent think-tanks, books analyzing the tenets and thinkers of Salafi radicalism and original source material confiscated from ISIL's predecessor al-Qaeda in Iraq (AQI). An international coalition is posited as a solution to the threat as well as the Middle Eastern terrorist threat more broadly. However, the likelihood of such international cooperation is minimal, and the commitment it would require may make it unfeasible.
ContributorsSims, Alyssa Gabrielle (Author) / Simon, Sheldon (Thesis director) / Ripley, Charles (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / W. P. Carey School of Business (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2015-05
Description
Modern medicine is a wonderfully complex field of study, with several advances in both its theoretical and practical aspects being made everyday. In light of the pride modern physicians and scientists take in their vast knowledge, it is important to remember how far we have come throughout history. Many civilizations and cultures around the world have made essential contributions to medicine, both great and small, but no one can deny the impact both ancient Chinese and Islamic medical and alchemical practices have had on modern medicine. Qi was the central principle behind Chinese correlative thought, and it was believed to be the one thing that drove human life, as it occurred everywhere. Written texts took an increasingly more prominent role in the transmission of knowledge, and in no time at all, the educated yi ("physician") emerged. Other noteworthy contributions include an early conceptualization of the circulatory system, the development of pharmacies, the establishment of proper medical school systems, and the emergence of a set of standard hygienic practices that would allow people to take responsibility for their own health. The scholars of the Islamic Golden Age, for the most part, seemed to decry the mixing of the occult with science, and therefore sought to draw a clear distinction between alchemy (by limiting its application to the transmutation of metals) and what they deemed "real" science. Notable contributions of Arab-Islamic scientists include the pioneering of a hospital prototype, along with the development of the science of chemistry and the introduction of the experimental laboratory as the birthplace of new scientific knowledge. The important question that has yet to be answered is how extensive the connection was between the Chinese and Arab worlds. Trade was thriving during the medieval period, and so it is not wrong to assume that the exchange of goods would go hand-in-hand with the exchange of knowledge. We may never fully know exactly what happened, but further research on this topic may eventually bring an answer to light.
ContributorsRaban, Miranda Meriam (Author) / Bokenkamp, Stephen (Thesis director) / Ling, Xiaoqiao (Committee member) / Ali, Souad T. (Committee member) / School of Historical, Philosophical and Religious Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Autism Spectrum Disorder (ASD) is a lifelong neurodevelopmental disorder that is becoming increasingly common. Autism does not yet have a known etiology, nor a definitive diagnostic test, thus making diagnosis a difficult and rarely uniform task. Currently, ASD is behaviorally diagnosed based on criteria defined by the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders (DSM). Recently, a change was made in the criteria from more lenient criteria in DSM-IV-TR, to more narrow criteria laid out by the DSM-V, which supersedes the DSM-IV-TR. This drastic change raised many questions and debates about which set of criteria are better. The more lenient criteria offers a more inclusive diagnosis giving greater access to therapies; while the narrow diagnostic criteria excludes some individuals, creating a more uniform diagnosis that's easier to use in research. This thesis analyzes the change in diagnostic criteria from the DSM-IV-TR to the DSM-V and the effects of these changes on the practices of diagnosis. In addition, it explores the implications of this change for the families of children with autism and for those involved in autism research, examining their respective opinions and interests pertaining to narrow verses broad diagnostic criteria. Building on this analysis, the thesis offers recommendations about diagnostic criteria should be set. It argues that the wellbeing of patients takes priority over the interests of researchers, and thus diagnosis should be done in a way that offers the best prognosis for all children who suffer from autistic symptoms.
ContributorsBremer, Michelle Nichole (Author) / Hurlbut, Ben (Thesis director) / Robert, Jason (Committee member) / Brian, Jennifer (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Cardiovascular disease is one of the most deadly outcomes of end stage renal disease. Bioelectrical impedance is a intriguing, yet unproven method of measuring fluid buildup in the heart, and is marketed as a early diagnostic tool for onset of cardiovascular disease. In this study, selenium supplements were given to a cohort of dialysis patients in the Phoenix metro area and their fluid tolerance was measured with thoracic biolectrical impedance. BNP was used as a correlate to see if bioelectrical impedance was correlated with heart disease. The study found no correlation between BNP and bioelectrical impedance and thus was not an accurate diagnostic tool in a medical setting.
ContributorsBrown, Patrick Michael (Author) / Johnston, Carol (Thesis director) / Orchinik, Miles (Committee member) / Tingey, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2013-05
Description
De Plantis Aegypti is a medical botany text from 1592, written by Prospero Alpini in Latin. In this text, Alpini details a variety of plants native and grown in Egypt, how they are grown, how they are processed, what they look like, and what if any edible and medical uses are documented. This project focused on transcribing and editing the Latin text, translating the Latin text into English, and comparing the medical claims to the modern scientific literature. This is the first translation of this text into English or any other language. Alpini also wrote two other books, which also have never been translated. The intended goal was to demonstrate that renaissance scholars understood medicine well, if not the mechanisms through which those medicines worked. After analyzing the modern scientific literature on the plants mentioned within the text, it was found that every medical use referenced in the text was either directly supported, indirectly supported, or there was no data from the literature. In other words, none of the medical uses were found to be disproved. On the other hand, quite a few of the plants actually had similar efficacies as modern pharmaceuticals. In addition to the notes on the modern science, there are also quite a few notes based on the grammar and the orthography of the text. This project is but a sampling of the plants mentioned De Plantis Aegypti, there are dozens more, which I plan on translating and doing a similar analysis on at a later date.
ContributorsPlamondon, Ian Lee (Author) / Poudrier, Almira (Thesis director) / Bjork, Robert (Committee member) / Egmond, Warren (Committee member) / School of Historical, Philosophical and Religious Studies (Contributor) / School of Molecular Sciences (Contributor) / School of International Letters and Cultures (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This dissertation investigates and describes the concept of precision medicine from historical, conceptual, capital investment, industry strategic, regulatory oversight, and medicalization perspectives. The study examines the various current and ongoing challenges, impacts, assimilations, and actual adaptive measures occurring within each of these areas as a result of the emergence and continued evolution of precision medicine as a medical discipline, as well as the technosocial advancements characteristic of precision medical products, such as companion diagnostics and targeted therapeutics, seeking market entry in the United States. The dissertation argues that there is a disjunction between precision medicine and historical governance, oversight, and medical practice mechanisms. Through case studies of two case products, Foundation Medicine’s F1CDx companion diagnostic and Novartis’ Kymriah CAR-T Cell therapeutic, the dissertation illustrates the impacts, destabilization and destandardization effects, and re-standardization efforts around a precision medicine diagnostic and therapy. As a central contribution, this dissertation demonstrates and illustrates the impact(s) that precision medicinal technologies are having on the technoscientific network involved in the creation, development, evaluation, governance, and implementation of medical products in the United States. Results revealed an emerging precision medical innovation model between and among member components of a precision medical ecosystem comprised of the above-mentioned focal areas and that, to fully understand the emerging precision medical innovation model, it is critical to understand not only the impacts of precision medical technologies on the individual components of the precision medicine ecosystem, but also the impacts, adaptations, assimilations, and occlusions inherent to the ecological relations within and across the ecosystem itself. Findings include the destabilization of the traditional drug development process across all stakeholder areas, characterized by the development of non-linear adaptive processes at both the premarket and post-market phases. Although the findings from this study are significant, it is likely that they are temporary in nature and will continue to evolve in accordance with the further advancement of precision medicine, ultimately re-stabilizing the precision medical development ecosystem.
ContributorsSeabrooke, Lee (Author) / Hurlbut, James B (Thesis advisor) / Miller, Clark (Thesis advisor) / Robert, Jason (Committee member) / Arizona State University (Publisher)
Created2021
Whistleblowing in Biomedical Research and Medicine: An Analysis of Ethical Expectations and Dilemmas
Description
In biomedical research institutions and medical institutions alike, whistleblowing, or the reporting of misconduct, has been severely retaliated against. Whistleblowers report misconduct by adhering to institutional whistleblowing policies, and do so in order to maintain ethical practice within their institution; it is important to note that by taking this ethical action, whistleblowers are aiming to protect the future of biomedical research and medicine. Despite these intentions, whistleblowing has developed a negative stigma due to the misconception that whistleblowers have self-proclaimed authority and are unable to function as part of a team. The retaliation against whistleblowers has been connected to psychological and professional fallout for the whistleblower, and it has been found that many whistleblowers suffer as a direct result of a lack of institutional support. The problems with whistleblowing culture demonstrate issues surrounding how ethics are maintained in institutions, who ethics policies apply to, and who has authority. The retaliation seen against whistleblowers outlines inherent institutional failures, and highlights the need for institutional change in order to both promote ethical practice and protect the whistleblowers who adhere to ethics policies. This thesis discusses such failures in detail, and outlines several broad solutions in order to combat this issue.
ContributorsTaylor, Kylee Anne (Author) / Robert, Jason (Thesis director) / Ellison, Karin (Committee member) / Johnson, Nate (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05