Matching Items (3)
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- All Subjects: Domestic Violence
- Creators: T. Denny Sanford School of Social and Family Dynamics
- Resource Type: Text
Description
Thank you to Dr. Larry Dumka, my CARE program director, for giving such constructive feedback on this project. Thank you Dr. Scott Christopher, my thesis director, for not only guiding me in the right direction of this project but also for encouraging me to apply to the CARE program and thank you for helping me to calculate my results section. Thank you to Dr. Sarah McKenney for taking the time and effort to be my third reader. Thank you to my classmates in my CARE program for being supportive and insightful throughout the course of this project. I would especially like to thank Kamber Goff for doing such a wonderful job editing my paper. I also want to thank Against Abuse, Inc for accepting the CARE proposal and allowing me to work with an organization that I have come to truly admire.
ContributorsOxford, Nikki Jean (Author) / Christopher, F.Scott (Thesis director) / Dumka, Larry (Committee member) / McKenney, Sarah (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor)
Created2013-05
Description
Dengue virus infects millions of people every year. Yet there is still no vaccine available to prevent it. Here we use a neutralizing epitope determinant on the dengue envelope (E) protein as an immunogen to be vectored by a measles virus (MV) vaccine. However the domain III (DIII) of the dengue 2 E protein is too small to be immunogenic by itself. In order for it to be displayed on a larger particle, it was inserted into the amino terminus of small hepatitis B surface antigen (HBsAg, S) coding sequence. To generate the recombinant MV vector and verify the efficiency of this concept, a reverse genetics system was used where the MV vectors express one or two additional transcription units to direct the assembly of hybrid HBsAg particles. Two types of recombinant measles virus were produced: pB(+)MVvac2(DIII-S,S)P and pB(+)MVvac2(DIII-S)N. Virus recovered from pB(+)MVvac2(DIII-S,S)P was viable. An ELISA assay was performed to demonstrate the expression and secretion of HBsAg. Supernatant from MVvac2(DIII-S,S)P infected cells confirmed that hybrid HBsAg-domain III particles with a density similar to traditional HBsAg particles were released. Characteristics of the subviral particle have been analyzed for the successful incorporation of domain III. The replication fitness of the recombinant MV was evaluated using multi-step growth kinetics and showed reduced replication fitness when compared to the parental strain MVvac2. This demonstrates that viral replication is hindered by the addition of the two inserts into MV genome. Further analysis of MVvac2(DIII-S)N is needed to justify immune response studies in a small animal model using both of the generated recombinant vectors.
ContributorsHarahap, Indira Saridewi (Author) / Reyes del Valle, Jorge (Thesis director) / Hogue, Brenda (Committee member) / Misra, Rajeev (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2014-05
Description
The purpose of this study was to investigate: 1) within police departments in Maricopa County, exactly who helps the families left behind after a domestic homicide occurs? 2) What kind of short-term resources are offered by the police to immediately help the family and any children affected? And 3) are long-term services provided to the family and children of domestic homicide victims, and if not, to where is the family referred? To answer these questions, employees from each of the 14 city police departments in Maricopa County were interviewed. Participants answered a serious of both open-ended and scale questions either via email or over the phone. This study found that all police departments in cities of Maricopa County (with the exception of Litchfield Park, which is covered by the Sherriff's Office) have what is referred to as a Victim Services Unit. This is a small team comprised of social workers and other employees specifically trained to provide a continuation of support to victims from the crisis period through the investigative and judicial processes. In terms of services provided, this study found that most of the services offered to victims through police departments in Maricopa County are short-term in nature and fall under one of the following categories: On-scene crisis intervention and initial needs-assessments, immediate basic needs and referrals, financial resources, counseling, family advocacy centers, legal advocacy and assistance with the criminal process, or Child Protective Services. Results also indicated a positive relationship between city size and the amount of resources provided to victims after a homicide. Finally, in regards to long-term resources, this study found in general, all long-term needs are handled by social service agencies and non-profits, which victims are connected to by police departments after a needs assessment has been conducted. Based on these findings, a number of recommendations were made to Purple Ribbon Council, a domestic abuse prevention and supportive care non-profit that were designed to help Purple Ribbon Council increase its reach and effectiveness.
ContributorsJones, Bethan Rhian (Author) / Dumka, Larry (Thesis director) / Pahlke, Erin (Committee member) / Durfee, Alesha (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / W. P. Carey School of Business (Contributor) / Department of Marketing (Contributor)
Created2013-05