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The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA

The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA shell surrounding the PLGA core. The microparticles were loaded with bovine serum albumin (BSA) and different volumes of ethanol were added to the PLA shell phase to alter the porosity and release characteristics of the BSA. Different amounts of ethanol varied the total loading percentage of the BSA, the release profile, surface morphology, size distribution, and the localization of the protein within the particles. Scanning electron microscopy images detailed the surface morphology of the different particles. Loading the particles with fluorescently tagged insulin and imaging the particles through confocal microscopy supported the localization of the protein inside the particle. The study suggest that ethanol alters the release characteristics of the loaded BSA encapsulated in the microparticles supporting the use of a polar, protic solvent as a tool for tuning the delayed release profile of biological proteins.
ContributorsFauer, Chase Alexander (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
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Description
With microspheres growing in popularity as viable systems for targeted drug therapeutics, there exist a host of diseases and pathology induced side effects which could be treated with poly(lactic-co-glycolic acid) [PLGA] microparticle systems [6,10,12]. While PLGA systems are already applied in a wide variety the clinical setting [11], microparticles still

With microspheres growing in popularity as viable systems for targeted drug therapeutics, there exist a host of diseases and pathology induced side effects which could be treated with poly(lactic-co-glycolic acid) [PLGA] microparticle systems [6,10,12]. While PLGA systems are already applied in a wide variety the clinical setting [11], microparticles still have some way to go before they are viable systems for drug delivery. One of the main reasons for this is a lack of fabrication processes and systems which produce monodisperse particles while also being feasible for industrialization [10]. This honors thesis investigates various microparticle fabrication techniques \u2014 two using mechanical agitation and one using fluid dynamics \u2014 with the long term goal of incorporating norepinephrine and adenosine into the particles for metabolic stimulatory purposes. It was found that mechanical agitation processes lead to large values for dispersity and the polydispersity index while fluid dynamics methods have the potential to create more uniform and predictable outcomes. The research concludes by needing further investigation into methods and prototype systems involving fluid dynamics methods; however, these systems yield promising results for fabricating monodisperse particles which have the potential to encapsulate a wide variety of therapeutic drugs.
ContributorsRiley, Levi Louis (Author) / Vernon, Brent (Thesis director) / VanAuker, Michael (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
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Description
A global trend towards cashlessness following the increase in technological advances in financial transactions lends way to a discussion of its various impacts on society. As part of this discussion, it is important to consider how this trend influences crime rates. The purpose of this project is to specifically investigate

A global trend towards cashlessness following the increase in technological advances in financial transactions lends way to a discussion of its various impacts on society. As part of this discussion, it is important to consider how this trend influences crime rates. The purpose of this project is to specifically investigate the relationship between a cashless society and the robbery rate. Using data collected from the World Bank’s Global Financial Inclusions Index and the United Nations Office of Drugs and Crime, we implemented a multilinear regression to observe this relationship across countries (n = 29). We aimed to do this by regressing the robbery rate on cashlessness and controlling for other related variables, such as gross domestic product and corruption. We found that as a country becomes more cashless, the robbery rate decreases (β = -677.8379, p = 0.071), thus providing an incentive for countries to join this global trend. We also conducted tests for heteroscedasticity and multicollinearity. Overall, our results indicate that a reduction in the amount of cash circulating within a country negatively impacts robbery rates.
ContributorsChoksi, Aashini S (Co-author) / Elliott, Keeley (Co-author) / Goegan, Brian (Thesis director) / McDaniel, Cara (Committee member) / School of International Letters and Cultures (Contributor) / Department of Economics (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description

This thesis details the impact of sustainable practices, or lack thereof, among IKEA and Chanel. It takes these principles and analyzes the effectiveness of them and works to implement them across industries and companies of different sizes and organizational structures.

ContributorsL'Heureux, Kendall James (Author) / Foote, Nicola (Thesis director) / Alcantara, Christiane (Committee member) / Department of Marketing (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Polymer drug delivery system offers a key to a glaring issue in modern administration routes of drugs and biologics. Poly(lactic-co-glycolic acid) (PLGA) can be used to encapsulate drugs and biologics and deliver them into the patient, which allows high local concentration (compared to current treatment methods), protection of the cargo

Polymer drug delivery system offers a key to a glaring issue in modern administration routes of drugs and biologics. Poly(lactic-co-glycolic acid) (PLGA) can be used to encapsulate drugs and biologics and deliver them into the patient, which allows high local concentration (compared to current treatment methods), protection of the cargo from the bodily environment, and reduction in systemic side effects. This experiment used a single emulsion technique to encapsulate L-tyrosine in PLGA microparticles and UV spectrophotometry to analyze the drug release over a period of one week. The release assay found that for the tested samples, the released amount is distinct initially, but is about the same after 4 days, and they generally follow the same normalized percent released pattern. The experiment could continue with testing more samples, test the same samples for a longer duration, and look into higher w/w concentrations such as 20% or 50%.

ContributorsSeo, Jinpyo (Author) / Vernon, Brent (Thesis director) / Pal, Amrita (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.

ContributorsHan, Priscilla (Author) / Vernon, Brent (Thesis director) / Nickle, Jacob (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

One of the most pressing questions in economics is “why are some countries richer than others?” One methodology designed to help answer the question is known as “Development Accounting,” a framework that organizes the determinants of income into two categories: differences in inputs and differences in efficiency. The objective of

One of the most pressing questions in economics is “why are some countries richer than others?” One methodology designed to help answer the question is known as “Development Accounting,” a framework that organizes the determinants of income into two categories: differences in inputs and differences in efficiency. The objective of our work is to study to what extent differences in the levels of pollution can help explain income differences across countries. To do this, we adjusted a factor-only model to allow us to enter PM2.5, a measure of pollution that tracks the concentration of fine particulate matter in the air and looked to see if the model’s predictive power improved. We ultimately find that we can improve the model’s success in predicting GDP by .5 - 6%. Thus, pollution is unlikely to be a major force in understanding cross-country income differences, but it can be used with other economic factors to potentially magnify its impact with other additions in the future.

ContributorsShelton, Jacinda Bridget (Co-author) / Perdue, Liam (Co-author) / Datta, Manjira (Thesis director) / Vereshchagina, Galina (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Department of Economics (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

This research explores the use of transformative urban scenarios and timelines as a planning tool for addressing future sustainability challenges in urban environments. The analysis comes from a set of scenarios that were explored through workshops conducted in 2019 in which Phoenix stakeholders developed timelines toward their visions of Phoenix

This research explores the use of transformative urban scenarios and timelines as a planning tool for addressing future sustainability challenges in urban environments. The analysis comes from a set of scenarios that were explored through workshops conducted in 2019 in which Phoenix stakeholders developed timelines toward their visions of Phoenix 60 years into the future. To evaluate the pathways created in these timelines, we employed process tracing methodology to understand which causal mechanisms lead to certain phenomena. Or in other words, it helps us understand how changes happen. We converted the timelines into process tracing diagrams that categorized the relationship between actions, actors, and observable manifestations (OM’s) of change over time. To understand the relationship between these components, we then used a combination of inductive and deductive coding to categorize types of activities, actors, OM’s and sustainability topics and organized them into themes. This helped us to understand how city decision-makers and community leaders think sustainability and resilience transformation can and should occur. This thesis takes a closer look at one particular scenario, Some Like it Hot, which explores resilience to extreme heat. Through coding and analysis, we found trends, correlations, and missing pieces in the participants’ timeline. There are numerous overarching causal mechanisms throughout the scenario timeline. These trends offer insight into which activities and stakeholders are seen as significant drivers of sustainable transformation according to the workshop participants. The file attached is a pdf version of an ArcGIS Story Map completed for this honors thesis. To view the full, interactive thesis deliverable, visit https://storymaps.arcgis.com/stories/14d1e52a9448498e87f20e7566651a13

ContributorsHarris, Madison (Author) / Caughman, Liliana (Thesis director) / Grimm, Nancy (Committee member) / Barrett, The Honors College (Contributor) / School of Geographical Sciences and Urban Planning (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2023-05
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Description
This paper intends to examine topics related to Chinese financial policy and
institutions mainly in the early 21st century. China has gone through enormous changes in the late 20th century and early 21st century, and financial policy reforms and adjustments have been at times instrumental to aiding that growth, and

This paper intends to examine topics related to Chinese financial policy and
institutions mainly in the early 21st century. China has gone through enormous changes in the late 20th century and early 21st century, and financial policy reforms and adjustments have been at times instrumental to aiding that growth, and at other times have served as impediments to the country’s success. As China’s clout has grown both economically and politically in the wider world, it has become evermore important to understand the Chinese financial system, particularly as other authoritarian regimes may seek to emulate it in the perhaps recent future. The paper will examine the institutional elements of Chinese finance, including the broader structure of the party state apparatus and the role of legislative and executive authorities in determining financial policy. Next, the paper will go through both the legal-regulatory environment of the country and the structure of the preeminent Chinese banks. Finally, issues in Chinese monetary policy, particularly exchange rate system reforms, and the developing stock and bond markets will be addressed.
ContributorsFeatherston, Ryan (Author) / Hill, John (Thesis director) / Mendez, Jose (Committee member) / Department of Economics (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
There exists a notable gender gap in the field of economics. One explanation for this gap is the low supply of women entering the economics labor market. To understand the shortage of female economics students, I observe students at the undergraduate and graduate level. My data consists of a sample

There exists a notable gender gap in the field of economics. One explanation for this gap is the low supply of women entering the economics labor market. To understand the shortage of female economics students, I observe students at the undergraduate and graduate level. My data consists of a sample of current undergraduate students and a sample of past Ph.D. applicants at Arizona State University. The gender gaps in these samples, both at the undergraduate and graduate level, can largely be explained by the variation in mathematical preparation of the students. The data reveals that undergraduate male economics students are more frequently enrolled in higher level math courses compared to female undergraduate students. Likewise, a higher number of male Ph.D. applicants have stronger mathematical backgrounds relative to female Ph.D. applicants. This common factor might explain the higher supply of male students who apply and get accepted to postgraduate studies in economics, relative to female students, holding all else constant. I conclude with the following recommended interventions: make information regarding postgraduate opportunities in economics more readily available, and increase math requirements for a bachelor’s degree in economics at ASU.
ContributorsZafari, Zorah (Author) / Datta, Manjira (Thesis director) / Zafar, Basit (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / School of Social Transformation (Contributor, Contributor) / Department of Economics (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05