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- Creators: Sanford School of Social and Family Dynamics
- Creators: School of Life Sciences
Description
Monoamine neurotransmitters (e.g., serotonin, norepinephrine, and dopamine) are powerful modulators of mood and cognitive function in health and disease. We have been investigating the modulation of monoamine clearance in select brain regions via organic cation transporters (OCTs), a family of nonselective monoamine transporters. OCTs are thought to complement the actions of selective monoamine transporters in the brain by helping to clear monoamines from the extracellular space; thus, assisting to terminate the monoamine signal. Of particular interest, stress hormones (corticosterone; CORT) inhibit OCT3-mediated transport of monoamine, to putatively lead to prolonged monoamine signaling. It has been demonstrated that stress levels of CORT block OCT3 transport in the rat hypothalamus, an effect that likely underlies the rapid, stress-induced increase in local monoamines. We examined the effect of chronic variable stress (CVS) on the development of mood disorders and OCT3 expression in limbic and hypothalamic regions of the rat brain. Animals subjected to CVS (14-days with random stressor exposure two times/day) showed reduced body weight gain, indicating that CVS was perceived as stressful. However, behavioral tests of anxiety and depressive-like behaviors in rats showed no group differences. Although there were no behavioral effects of stress, molecular analysis revealed that there were stress-related changes in OCT3 protein expression. In situ hybridization data confirmed that OCT3 mRNA is expressed in the hippocampus, amygdala, and hypothalamus. Analysis of Western blot data by two-way ANOVA revealed a significant treatment effect on OCT3 protein levels, with a significant decrease in OCT3 protein in the amygdala and hippocampus in CVS rats, compared to controls. These data suggest an important role for CORT sensitive OCT3 in the reduction of monoamine clearance during stress.
ContributorsBoyll, Piper Savannah (Author) / Orchinik, Miles (Thesis director) / Conrad, Cheryl (Committee member) / Talboom, Joshua (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
ABSTRACT
Background: Although aerobic exercise has been shown to improve the glycemic control of individuals with type 2 diabetes, a simple and effective approach to manage post-meal glycemic control remains less clear.
Purpose: This study examined the effect of 15-minute of post-meal aerobic exercise on the glycemic control and anxiety scores as compared with control trials in participants with and without type 2 diabetes.
Methods: Six adults volunteered to participate in the study (3 adults with type 2 diabetes, age = 44.33 ± 7.71; and 3 adults without type 2 diabetes, age = 31.67 ± 15.76). All participants received aerobic exercise intervention and control treatments. The aerobic exercise treatment was listening to upbeat music and dancing for 15-minutes, whereas the control participants ingested 1 gram of vitamin C 30-minutes post-meal. Glucose levels were measured at baseline, and the 10, and 15-minute mark in both exercise intervention and control conditions 30-minutes post-meal.
Results: There was a significant interaction between treatment and time on the change in glucose levels (P<0.001). There was a significant mean difference in change in glucose levels between exercise intervention and control conditions (P = 0.002). Change in glucose levels in exercise intervention was significantly decreased at 10-minute (-18 ± 4.35 vs. 1.67 ± 4.34, P = 0.009) and 15-minute (-24 ± 4.88 vs. 5.67 ± 4.88, P = 0.001) compared with control condition. Although there were no statistical differences in state anxiety scores between pre- and post-exercise intervention (p=0.42), there was a significant trend in the reduction of state anxiety scores in diabetic participants, as compared with healthy participants, after 15-minute exercise intervention (-8 vs. -1).
Conclusion: Aerobic exercise for 15-minute by dancing to music after a meal is an effective approach to controlling the blood glucose levels in type 2 diabetic and healthy persons.
Background: Although aerobic exercise has been shown to improve the glycemic control of individuals with type 2 diabetes, a simple and effective approach to manage post-meal glycemic control remains less clear.
Purpose: This study examined the effect of 15-minute of post-meal aerobic exercise on the glycemic control and anxiety scores as compared with control trials in participants with and without type 2 diabetes.
Methods: Six adults volunteered to participate in the study (3 adults with type 2 diabetes, age = 44.33 ± 7.71; and 3 adults without type 2 diabetes, age = 31.67 ± 15.76). All participants received aerobic exercise intervention and control treatments. The aerobic exercise treatment was listening to upbeat music and dancing for 15-minutes, whereas the control participants ingested 1 gram of vitamin C 30-minutes post-meal. Glucose levels were measured at baseline, and the 10, and 15-minute mark in both exercise intervention and control conditions 30-minutes post-meal.
Results: There was a significant interaction between treatment and time on the change in glucose levels (P<0.001). There was a significant mean difference in change in glucose levels between exercise intervention and control conditions (P = 0.002). Change in glucose levels in exercise intervention was significantly decreased at 10-minute (-18 ± 4.35 vs. 1.67 ± 4.34, P = 0.009) and 15-minute (-24 ± 4.88 vs. 5.67 ± 4.88, P = 0.001) compared with control condition. Although there were no statistical differences in state anxiety scores between pre- and post-exercise intervention (p=0.42), there was a significant trend in the reduction of state anxiety scores in diabetic participants, as compared with healthy participants, after 15-minute exercise intervention (-8 vs. -1).
Conclusion: Aerobic exercise for 15-minute by dancing to music after a meal is an effective approach to controlling the blood glucose levels in type 2 diabetic and healthy persons.
ContributorsSymons, Nicholas Payne (Author) / Lee, Chong (Thesis director) / Dickinson, Jared (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / W. P. Carey School of Business (Contributor)
Created2015-05
Description
More than 260 million people suffer from an anxiety disorder worldwide, with 40 million in the U.S. alone—18% of the American population. And that label includes everything from Social Anxiety and Posttraumatic Stress Disorder to phobias and Obsessive Compulsive Disorder. Thus, people with anxiety may not have a singular cause for their worry, but a myriad number of them that influence every aspect of their lives. And, that doesn’t include people who’ve never been formally diagnosed and don’t receive proper medication or therapy.
Unfortunately, medication has many possible side effects, and both medication and therapy are often expensive. However, there are alternatives for someone dealing with anxiety. This book proposal offers a range of solutions for anxiety management, from do it yourself techniques like guided imagery and yoga, to biofeedback devices like HeartMath, to research trials on Eye Movement Desensitization and Reprocessing, as well as Repetitive Transcranial Magnetic Stimulation. The idea was not to outline every potential solution for anxiety, but to educate people on available opportunities and empower them to take control.
Though anxiety can be managed and reduced, there is no cure. That’s because anxiety is a normal part of life, and in most cases a helpful evolutionary tool to keep people on track. But, when this anxiety becomes a burden on someone’s life, there is a plethora of alternative solutions available. Understanding anxiety and learning to manage it is not an impossible task. This thesis provides an introduction to the idea and then allows the reader to move forward on their own path as they choose.
Unfortunately, medication has many possible side effects, and both medication and therapy are often expensive. However, there are alternatives for someone dealing with anxiety. This book proposal offers a range of solutions for anxiety management, from do it yourself techniques like guided imagery and yoga, to biofeedback devices like HeartMath, to research trials on Eye Movement Desensitization and Reprocessing, as well as Repetitive Transcranial Magnetic Stimulation. The idea was not to outline every potential solution for anxiety, but to educate people on available opportunities and empower them to take control.
Though anxiety can be managed and reduced, there is no cure. That’s because anxiety is a normal part of life, and in most cases a helpful evolutionary tool to keep people on track. But, when this anxiety becomes a burden on someone’s life, there is a plethora of alternative solutions available. Understanding anxiety and learning to manage it is not an impossible task. This thesis provides an introduction to the idea and then allows the reader to move forward on their own path as they choose.
ContributorsSchneider, Sage Ann (Author) / deLusé, Stephanie (Thesis director) / Boyd, Patricia (Committee member) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor) / Department of English (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
An increasing number of veterans are transitioning from military service to college. Critical to academic success is the process of decision-making, which previous research has found to be influenced by a variety of factors including anxiety and working memory (WM). Many service-related conditions often influence anxiety and WM, and given the high prevalence of these conditions among veterans, the present study aimed to analyze the effects of working memory and anxiety on decision-making behavior in U.S. Military Veterans. Participants completed a large test battery including tasks assessing WM skills (Symmetry Span Task), anxiety (Beck Anxiety Inventory), and decision-making (Iowa Gambling Task). The study results indicated that WM and anxiety both play roles in decision-making performance in young military veterans. High anxiety is related to increased avoidance of adverse outcomes in decision-making for U.S. Military Veterans, while lower working memory span is associated with greater risk-taking behavior. This study provides both functional and clinical implications into areas of possible intervention that need to be assessed in military veterans, as well as modifications to these assessments that need to be made in order to appropriately measure decision-making behavior. Future work will be done in order to more effectively analyze the adverse impacts of service-related conditions and the ways in which intervention can be implemented in order to minimize these effects.
ContributorsTully, Mckayla Lynne (Author) / Azuma, Tamiko (Thesis director) / Gallagher, Karen (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Department of Speech and Hearing Science (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Depression, anxiety, and suicidal thoughts or actions are on the rise in adolescents (National Institute of Mental Health, 2015; Bridge, Asti, & Horowitz, 2015). Parents, school administrators, and therapists are searching for resiliency factors with in at-risk groups to aid students in need. In previous work, Luthar and Zigler (1992) reported that intelligent youth are more resilient than less intelligent youth under low stress conditions but they lose their advantage under high stress conditions. This study examined whether intelligence (reflected in grade point average; GPA) and maladaptive (internalizing and externalizing symptoms) behaviors are negatively related in adolescents, and tested whether level of stress, reflected in emotion regulation and friendship quality, moderated that association. It also probed whether the relationships differ by gender. Sixth-graders (N=506) were recruited with active parental consent from three middle schools. Adolescents completed self-report questionnaires Regarding demo graphics, maladaptive behaviors, emotion regulation, and friendship quality, and GPA data were collected from the school. Regression analyses found that GPA was negatively related to externalizing symptoms. Girls with poor friendship communication report significantly higher maladaptive behaviors. This relation was more pronounced for girls with high GPAs, as predicted. Results support the theory that intelligent female adolescents are more reactive under adverse circumstances. Future efforts should follow students through middle school into high school to evaluate whether friendships remain important to adjustment, hold for boys as well as girls, and have implications for relationship interventions.
ContributorsGonzales, Ashlyn Carol (Author) / Luthar, Suniya (Thesis director) / Davis, Mary (Committee member) / Infurna, Frank (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
Affluent children have been previously understudied and considerably neglected in developmental research due to the notion that they are "low risk." There is limited empirical research exploring the effects of parent involvement in affluent youth: specifically, the importance of the adolescent's perception that their mother/father do not spend as much time with them as they would like. The goals of the study were to explore the role of this dimension of perceived parental involvement in anxious-depressed symptoms, somatic symptoms, rule breaking behaviors and substance use with upper-class suburban youth. The sample was taken from the New England Study of Suburban Youth Cohort (NESSY) (Luthar & Latendresse, 2005b) consisting of 252 high school students in the 12th grade located in an affluent community in the Northeast. Results showed that the participants who indicated their fathers could have dinner with them more often if they tried presented significant group differences in anxious-depressed symptoms, somatic symptoms, and rule breaking behaviors while substance use trended towards significant. Thus, these data demonstrate that parent-child relationships are not only important for infant and child development, but are also an integral part of development of adaptive behaviors during adolescence. In addition, the data suggest the benefits from having strong, supportive, and stable relationships with not only mothers but with fathers as well. Results from post hoc analyses revealed perceived absence of fathers at dinnertime affects the adolescent more than the perceived absence of mothers at dinnertime. Finally, teens who indicated a need to spend more dinnertimes with their father may be suffering from a lack of open communication and opportunities to discuss social and emotional issues that are conducive to adolescent development and adjustment.
ContributorsOjeda, Johanna Alyssa Quiambao (Author) / Luthar, Suniya (Thesis director) / Glenberg, Arthur (Committee member) / Curlee, Alexandria (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Anxiety is one of the most common mental illnesses in the United States. In this project, I chose to explore how food is one of the most accessible and inexpensive ways of treating anxiety. This creative project examines the major key components of gut health including the balance of neurotransmitters and bacteria in the gut, restoring hydrochloric acid through celery juice, removing heavy metal toxins through food, eating fermented foods, and limiting refined carbohydrates, and high-sugar consumption. Additionally, this creative project explores my own personal journey through the implementation of foods that influence anxiety revealed in a systemic review over the course of a 6-week period.
ContributorsHunter, Madelyn Grace (Author) / Hart, Teresa (Thesis director) / Barth, Christina (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Exercise has emerged as an effective way to treat anxiety and depression. This project first examines the early research on this topic so we can provide a historical context for the thesis. We then look into the contemporary context, where we can see how the topic is being talked about in modern forms of media. Finally, we apply the research to college students. At the end of the paper, you will find a brochure we made specifically for the college student struggling with anxiety or depression.
ContributorsRitter, Hailey (Author) / Cristante, Lilia (Co-author) / Sturgess, Jessica (Thesis director) / Hoffner, Kristin (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor)
Created2022-05
Description
Sophia’s Stuffed Friends is a book written for children of divorce, aged five to eight years. The story deals with anxiety, depression, and misappropriated guilt in the form of character traits in Sophia’s stuffed animals. The story takes place in a dream world after the stuffed animals are thrown into the washer of the new family house. The washer acts as a portal to the dream world. The lessons of the story are learned through flashbacks to Sophia’s life when she personally experienced anxiety, depression, and guilt. Each character learns coping mechanisms and strategies to overcome those feelings.
Squeakie is a positive influence on the way the other characters perceive themselves. The shadow turns each character’s self-doubt and negative feelings into fuel, which he stores in a paintbrush. When he takes the fuel from the character, it fades their body color. Phan has anxiety and uses the 4-7-8 breathing technique to overcome her panic attacks. Her range of color is blue to light blue. Ovid feels guilty and exercises to take his mind off his guilty thoughts. Ovid is either red or light pink. Amelia is depressed and reframes her way of thinking to overcome her inability to fly. Visually she is green or light green. The shadow is later revealed as a misguided character who was just looking to escape the dream world and find friends.
The story is resolved by the stuffed animals joining forces with the perceived antagonist, the shadow, to operate a plane. They each use their strength of color to fuel the plane, which takes them back to the real world. When Sophia’s mom pulls the stuffed animals out of the washer, the shadow comes with them. The shadow, now a cat with rainbow patches, is instantly loved by Sophia. The story ends with the stuffed animals drying on the porch bench while Sophia plays with the shadow in the new backyard.
Squeakie is a positive influence on the way the other characters perceive themselves. The shadow turns each character’s self-doubt and negative feelings into fuel, which he stores in a paintbrush. When he takes the fuel from the character, it fades their body color. Phan has anxiety and uses the 4-7-8 breathing technique to overcome her panic attacks. Her range of color is blue to light blue. Ovid feels guilty and exercises to take his mind off his guilty thoughts. Ovid is either red or light pink. Amelia is depressed and reframes her way of thinking to overcome her inability to fly. Visually she is green or light green. The shadow is later revealed as a misguided character who was just looking to escape the dream world and find friends.
The story is resolved by the stuffed animals joining forces with the perceived antagonist, the shadow, to operate a plane. They each use their strength of color to fuel the plane, which takes them back to the real world. When Sophia’s mom pulls the stuffed animals out of the washer, the shadow comes with them. The shadow, now a cat with rainbow patches, is instantly loved by Sophia. The story ends with the stuffed animals drying on the porch bench while Sophia plays with the shadow in the new backyard.
ContributorsWheeler, Isabella (Author) / Wells, Cornelia (Thesis director) / Fontinha de Alcantara, Christiane (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-12
Description
ADHD is a neurodevelopmental disorder associated with a high rate of comorbidity with anxiety disorders (25-34%). Children with ADHD experience serious adverse outcomes secondary to impairment in executive function, particularly within the domain of working memory (WM), behavioral inhibition (BI), and sustained attention (SA). While executive function deficits in ADHD are well documented, whether and how comorbid anxiety affects cognitive performance are equivocal. One potential explanation is that most studies examine linear relations, yet evidence suggests that anxiety affects performance in a non-linear (quadratic) manner, consistent with the the Yerkes-Dodson Law. The aim of this study was to investigate whether 1) children with ADHD show deficits in WM, BI, and SA relative to typically developing children, 2) comorbid anxiety displays a linear or nonlinear relationship with WM, BI, and SA performance among children with ADHD and 3) between group differences in cognitive performance vary based on levels of anxiety. Linear and non-linear relations between anxiety and cognitive performance were assessed in a sample of 54 boys diagnosed with ADHD and 50 typically developing boys. Anxiety was assessed across dimensions and raters. Results indicate rater and domain-specific effects of comorbid anxiety on cognitive performance. Non-linear relations between children’s self-rated physiological anxiety and Phonological working memory (PHWM), Visuospatial working memory (VSWM), and the Central Executive (CE) were found. Non-linear relations between parent-rated anxiety and PHWM and the CE were also found. However, no significant linear or non-linear effects of anxiety on BI and SA were found. The results indicate that children with moderate self-rated and parent-rated anxiety performed better on WM measures relative to those with low and high levels of self-rated and parent-rated anxiety. The present study was the first to examine and document non-linear effects of anxiety on cognitive performance among children diagnosed with ADHD. Given the results, clinicians should continue to assess anxiety during diagnostic screening in ADHD samples. Treatments should focus on compensating for CE abilities and mitigating high levels of anxiety as it may further impair WM.
ContributorsRivard, Ashley (Author) / Friedman, Lauren (Thesis director) / Corbin, William (Committee member) / Brewer, Gene (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / School of Life Sciences (Contributor)
Created2022-05