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- Creators: Barrett, The Honors College
Description
Neuroinflammation is an important secondary injury response occurring after traumatic brain injury (TBI). Anxiety-like disorders are commonly exacerbated after TBI and are mediated through the amygdala; however, the amygdala remains understudied despite its important contribution in processing emotional and stressful stimuli. Therefore, we wanted to study neuroinflammation after experimental TBI using midline fluid percussion in rodent models. We assessed microglia morphology over time post-injury in two circuit related nuclei of the amygdala, the basolateral amygdala (BLA) and central amygdala of the nucleus (CeA), using skeletal analysis. We also looked at silver staining and glial fibrillary acidic protein (GFAP) to evaluate the role of neuropathology and astrocytosis to evaluate for neuroinflammation in the amygdala. We hypothesized that experimental diffuse TBI leads to microglial activation in the BLA-CeA circuitry over time post-injury due to changes in microglial morphology and increased astrocytosis in the absence of neuropathology. Microglial cell count was found to decrease in the BLA at 1 DPI before returning to sham levels by 28 DPI. No change was found in the CeA. Microglial ramification (process length/cell and endpoints/cell) was found to decrease at 1DPI compared to sham in the CeA, but not in the BLA. Silver staining and GFAP immunoreactivity did not find any evidence of neurodegeneration or activated astrocytes in the respectively. Together, these data indicate that diffuse TBI does not necessarily lead to the same microglial response in the amygdala nuclei, although an alternative mechanism for a neuroinflammatory response in the CeA likely contributes to the widespread neuronal and circuit dysfunction that occurs after TBI.
ContributorsHur, Yerin (Author) / Newbern, Jason (Thesis director) / Thomas, Theresa Currier (Committee member) / Beitchman, Joshua (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Autism spectrum disorder (ASD) is highly comorbid with mood disorders, such as depression and anxiety. Previous research suggests difficulties in emotion regulation to be concordant with experiencing these comorbid symptoms. Understanding the neural correlates of emotion regulation in ASD and relationships with mood symptoms could provide insights for effective treatments. We employed an existing functional MRI paradigm to assess neural activation during an emotional regulation task in adults with ASD, and correlate activated regions with self-reported measures of depression and anxiety. We found the following regions to be significantly associated with emotion regulation (family-wise error corrected p<0.05): the bilateral insula, anterior cingulate, middle cingulate, precentral gyrus, angular gyrus, left dorsolateral PFC, right caudate/putamen, and left medial PFC. We found anxiety, but not depression, symptoms were negatively correlated with activation in the anterior cingulate, left insula, and left putamen, and showed a moderate relationship to the amygdala. These results expand current understanding of ASD and emotion regulation and suggest targets for future clinical intervention.
ContributorsHaynes, Caleb River (Author) / Braden, Brittany Blair (Thesis director) / Leslie, Baxter (Committee member) / Mary, Davis (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
In the age of social media, the 24-hour news cycle, and an overwhelming pressure to become "successful," there is a marked lack of personal connection within communities and a constant state of stress and overwork. This constant state of stress then builds into anxiety, as there are few public resources for mental reprieve. The World Health Organization reports that anxiety disorders are the most common mental disorders worldwide, begging the question as to how they can be addressed most effectively worldwide. As design is implicit within any environment that provides for mental wellness, it must be carefully curated to provide not only the physical necessities, but speak for something beyond explanation- a sense of mental refuge and comfort. Using the concept of mindfulness, architecture has the power to force users to truly be present in the experience, activating space to become a mental refuge rather than a passive infrastructure.
ContributorsDickson, Cassandra (Author) / Horton, Philip (Thesis director) / Heywood, William (Committee member) / Hejduk, Renata (Committee member) / The Design School (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
In Memory of an Emily is a piece of creative nonfiction and a short film that together detail the author’s experience with mental illness in the collegiate environment. In its 45 pages, Jackman begins to detail the realities of living with depression, anxiety, and anorexia nervosa. The piece includes five sections of writing, including a preface and four portions describing freshman to senior year. Each section endeavors to explore simplistic and purposefully cliché events common in young adult/collegiate life and juxtapose the banal nature of these events with the experience of the mentally ill. Her story endeavors to explore the emotional truths of pain and suffering, revealing that beneath her tender façade lies a very different existence, one tangled in eating disorders, panic attacks, and overwhelming sadness. While maintaining a story-like quality traditional to creative non-fiction, Jackman ventures to warn with a cautionary tale of pathologizing abnormality and exploring the long lasting effects of childhood trauma. Weaving careful storytelling into an exploration of the mentally ill mind, Jackman keeps the reader both terrifyingly close and far away, whispering painful secrets and then desperately running away with the truth. She speaks frankly of all aspects of life, ranging from far more mundane events, such as break ups and college rejection letters, to complicated issues, such as the suicide of her grandfather and her admission into an eating disorder facility. The author attempts to establish a balanced rapport with the reader, recognizing the need to maintain distance and elicit emotion simultaneously. Jackman writes In Memory of an Emily as a heartbreaking but authentic tale, playing with stream of consciousness and paralyzing emotional description. She opens the door and invites the reader into her mind so as to share in the physical and emotional discomfort of the storyteller, but then promptly slams the door once inside.
ContributorsJackman, Emily Deprey (Author) / Soares, Rebecca (Thesis director) / Barca, Lisa (Committee member) / Economics Program in CLAS (Contributor) / Department of Psychology (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The levels of student-perceived anxiety and attention in the Italian language classroom were evaluated. The central evaluation focused on the differences between how students experience anxiety and attention between Italian language and non-language courses. First-year Italian language students were surveyed using a self-report measure to identify individual levels of anxiety and attention during Elementary Italian I (ITA 101) courses compared to their experiences in non-language 100-level courses. A total of 65 responses were collected from the ITA 101 students of four different professors at Arizona State University. It was hypothesized that students experience more anxiety and pay greater attention during language courses in comparison to non-language courses. However, the differences between how students experienced both attention and anxiety across language and non-language course types was not significant. Using the demographic and supplementary questions from the survey, the differing experiences of students with or without previous language experience were examined. The results suggest a significant relationship between students with language experience and how they experience attention in Italian language courses. Additionally, statistical analysis suggests that students experience anxiety differently in Italian language courses dependent on previous second language experience. Implications for language course prerequisites were identified and suggest that it is beneficial for students to have prior second language experience before enrolling in Italian courses. Suggestions for future research were made, including a suggestion for additional research to explore how anxiety and attention may differ in higher-level language courses in addition to a suggestion for creating a more reliable and valid survey for testing classroom anxiety and attention levels.
ContributorsHoren, Sophia Louise (Author) / Dal Martello, Chiara (Thesis director) / Dell'Anna, Antonella (Committee member) / School of Social Work (Contributor) / Division of Teacher Preparation (Contributor) / School of International Letters and Cultures (Contributor) / School of Public Affairs (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
An increasing number of veterans are transitioning from military service to college. Critical to academic success is the process of decision-making, which previous research has found to be influenced by a variety of factors including anxiety and working memory (WM). Many service-related conditions often influence anxiety and WM, and given the high prevalence of these conditions among veterans, the present study aimed to analyze the effects of working memory and anxiety on decision-making behavior in U.S. Military Veterans. Participants completed a large test battery including tasks assessing WM skills (Symmetry Span Task), anxiety (Beck Anxiety Inventory), and decision-making (Iowa Gambling Task). The study results indicated that WM and anxiety both play roles in decision-making performance in young military veterans. High anxiety is related to increased avoidance of adverse outcomes in decision-making for U.S. Military Veterans, while lower working memory span is associated with greater risk-taking behavior. This study provides both functional and clinical implications into areas of possible intervention that need to be assessed in military veterans, as well as modifications to these assessments that need to be made in order to appropriately measure decision-making behavior. Future work will be done in order to more effectively analyze the adverse impacts of service-related conditions and the ways in which intervention can be implemented in order to minimize these effects.
ContributorsTully, Mckayla Lynne (Author) / Azuma, Tamiko (Thesis director) / Gallagher, Karen (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Department of Speech and Hearing Science (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Research supports that music therapy can be used in multiple aspects of care for patients living within different environments. There is a gap in the literature when it comes to the impact of music sessions for older adults who do not have a diagnosed disease, therefore this study analyzes this population specifically. This study examines music therapy and its effects on anxiety and depression in adults aged 65 or older living in independent living homes. The adults participated in a mixed-methods study over the span of one month examining music as an intervention to decrease anxiety and depression. Each subject consented into the study, completed a demographic survey, answered open-ended questions regarding their experience with anxiety/sadness and ways to cope, as well as Profile of Moods Scale (POMS) during the first session. On the last week of the study, the participants were asked to fill out the same POMS scale to evaluate whether music influenced anxiety and depression. There was limited evidence found in this study to support the use of music therapy as an intervention to decrease anxiety and depression in adults over the age of 65.
ContributorsWolfus, Sarah Ilyssa (Author) / Lee, Rebecca (Thesis director) / Larkey, Linda (Committee member) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Depression, anxiety, and suicidal thoughts or actions are on the rise in adolescents (National Institute of Mental Health, 2015; Bridge, Asti, & Horowitz, 2015). Parents, school administrators, and therapists are searching for resiliency factors with in at-risk groups to aid students in need. In previous work, Luthar and Zigler (1992) reported that intelligent youth are more resilient than less intelligent youth under low stress conditions but they lose their advantage under high stress conditions. This study examined whether intelligence (reflected in grade point average; GPA) and maladaptive (internalizing and externalizing symptoms) behaviors are negatively related in adolescents, and tested whether level of stress, reflected in emotion regulation and friendship quality, moderated that association. It also probed whether the relationships differ by gender. Sixth-graders (N=506) were recruited with active parental consent from three middle schools. Adolescents completed self-report questionnaires Regarding demo graphics, maladaptive behaviors, emotion regulation, and friendship quality, and GPA data were collected from the school. Regression analyses found that GPA was negatively related to externalizing symptoms. Girls with poor friendship communication report significantly higher maladaptive behaviors. This relation was more pronounced for girls with high GPAs, as predicted. Results support the theory that intelligent female adolescents are more reactive under adverse circumstances. Future efforts should follow students through middle school into high school to evaluate whether friendships remain important to adjustment, hold for boys as well as girls, and have implications for relationship interventions.
ContributorsGonzales, Ashlyn Carol (Author) / Luthar, Suniya (Thesis director) / Davis, Mary (Committee member) / Infurna, Frank (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
Everyone experiences feelings of anxiety. This is part of being human. However, occasional stress and worry does not compare with today's rising epidemic of Anxiety Disorders, especially in the creative industry. A widespread stigma surrounding mental health, our high-stress culture, and rising medical costs leaves most of those suffering without treatment. Those that end up seeking treatment face the challenge of finding the right combination, to bring their overpowering anxiety down to a manageable level. The most common treatments include therapy, medication, and lifestyle changes. Alternative treatments such as meditation, exercise, and self-care have a great impact on reducing anxiety when combined with traditional treatments. Despite the fact that anxiety has become a cultural condition, we can end this epidemic by speaking up and offering the right support, often off the beaten path.
ContributorsSmith, Willow (Author) / Heywood, William (Thesis director) / Sanft, Alfred (Committee member) / The Design School (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Affluent children have been previously understudied and considerably neglected in developmental research due to the notion that they are "low risk." There is limited empirical research exploring the effects of parent involvement in affluent youth: specifically, the importance of the adolescent's perception that their mother/father do not spend as much time with them as they would like. The goals of the study were to explore the role of this dimension of perceived parental involvement in anxious-depressed symptoms, somatic symptoms, rule breaking behaviors and substance use with upper-class suburban youth. The sample was taken from the New England Study of Suburban Youth Cohort (NESSY) (Luthar & Latendresse, 2005b) consisting of 252 high school students in the 12th grade located in an affluent community in the Northeast. Results showed that the participants who indicated their fathers could have dinner with them more often if they tried presented significant group differences in anxious-depressed symptoms, somatic symptoms, and rule breaking behaviors while substance use trended towards significant. Thus, these data demonstrate that parent-child relationships are not only important for infant and child development, but are also an integral part of development of adaptive behaviors during adolescence. In addition, the data suggest the benefits from having strong, supportive, and stable relationships with not only mothers but with fathers as well. Results from post hoc analyses revealed perceived absence of fathers at dinnertime affects the adolescent more than the perceived absence of mothers at dinnertime. Finally, teens who indicated a need to spend more dinnertimes with their father may be suffering from a lack of open communication and opportunities to discuss social and emotional issues that are conducive to adolescent development and adjustment.
ContributorsOjeda, Johanna Alyssa Quiambao (Author) / Luthar, Suniya (Thesis director) / Glenberg, Arthur (Committee member) / Curlee, Alexandria (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12