Matching Items (7)
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- Creators: School of Social and Behavioral Sciences
- Status: Published
Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
Revenge porn is the accepted term used to describe the distribution of explicit photos online with the intent to incite embarrassment or shame. Perpetrators are typically ex-lovers seeking revenge on a former partner. This harassment has become widespread alongside increased access to online networks and "sexting" culture. Early studies indicate revenge porn reflects a larger cultural attitude of "slut shaming", the tendency to shame women for behaving in a sexual manner outside the boundaries of traditional female sexuality. Focus groups were organized to discuss views regarding revenge porn, Internet privacy, and legislature.
ContributorsEikren, Emilee Irene (Author) / Ingram-Waters, Mary (Thesis director) / Christopher, Scott (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / School of Social Transformation (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description
This thesis argues that our current attitudes toward meat consumption should be questioned for multiple reasons: because eating meat is cruel to the animals being eaten, it is detrimental to the environment, it is not at all necessary for a balanced diet, and lastly because the amount of faux meat options are endless. To begin the thesis describes the types of meat filled food that surrounds all of us, as Americans, in our everyday lives. It then meditates on the history of these other non-meat choices, in order to show how important faux meat has been throughout time for various cultures and religions. The work then continues from the past to the present, and profiles the growing availability and abundance of faux meat products in North American culture. In doing this it presents the current vegetarian meat options available to the average American consumer. In hopes of convince consumers that choosing ethically doesn't have to mean choosing blandly, it presents reviews of the taste, texture, and physical appearance of the more popular faux meat products on the market today. After which it turns to the future and commends technological and scientific endeavors in the search for a new cruelty free meat source through in-vitro meat research. And finally this thesis explains the disastrous environmental impact of our current meat filled diets. It concludes that the strong westerner tradition of eating meat is not necessarily the right way to eat. By purchasing and eating meat the consumer is voting, with their dollar, for animal abuse and environmental destruction. The consequences of eating meat are atrocious enough that if people are given a more ethical, delicious, and cheap meat-alternative they will chose it.
ContributorsGuinn, Victoria E (Author) / Ramsey, Ramsey E. (Thesis director) / Gruber, Diane (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor) / WPC Graduate Programs (Contributor)
Created2015-05
Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description
Menstruation curricula in elementary schools presents an opportunity to better examine the early teachings about menstruation, as this is often the first time that young people learn about gender difference within school sanctioned curricula. A closer examination of this pedagogical moment from the perspective of educators helps us to understand the dissemination of the shame narrative present in menstrual socialization. Six teachers were interviewed about their experiences with administering the menstrual health curriculum in elementary schools across a large southwest metropolitan area. A discourse analysis of these interviews was completed in order to find themes of language used surrounding menstrual health curriculum. Themes of shame, legislative restrictions on sex education curriculum and personal narratives surrounding menstruation are discussed in addition to the current neo-liberal structure of public health curriculum. Future research into alternative modes of education on menstruation is proposed.
ContributorsGonzalez, Jaqueline Jean (Author) / Fahs, Breanne (Thesis director) / Grzanka, Patrick (Committee member) / Barrett, The Honors College (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2014-05
Description
Bexarotene (Bex) is a FDA-approved drug used to treat cutaneous T-cell lymphoma (CTCL). It binds with high affinity to the retinoid-X-receptor (RXR), a nuclear receptor implicated in numerous biological pathways. Bex may have the potential to attenuate estrogenic activity by acting as an estrogen receptor alpha (ERα) signaling antagonist, and can therefore be used to treat ERα-positive cancers, such as breast cancer. Using dual luciferase reporter assays, real-time qRT-PCR, and metabolic proliferation assays, the anti-estrogenic properties of Bex were ascertained. However, since Bex produces numerous contraindications, select novel RXR drug analogs were also evaluated. Results revealed that, in luciferase assays, Bex could significantly (P < 0.01) inhibit the transcriptional activity of ERα, so much so that it rivaled ER pan-antagonist ZK164015 in potency. Bex was also able to suppress the proliferation of two breast cancer cell models, MCF-7 and T-47D, and downregulate the expression of an estrogen receptor target gene (A-myb), which is responsible for cell proliferation. In addition, novel analogs A30, A33, A35, and A38 were evaluated as being more potent at inhibiting ERE-mediated transcription than Bex at lower concentrations. Analogs A34 and A35 were able to suppress MCF-7 cell proliferation to a degree comparable to that of Bex. Inhibition of T-47D cell proliferation, by contrast, was best achieved by analogs A34 and A36. For those with ERα – positive breast cancer who are refractory to current chemotherapeutics used to treat breast cancer, Bex and its analogs may prove to be useful alternative options.
ContributorsBains, Supreet (Author) / Jurutka, Peter (Thesis director) / Hackney Price, Jennifer (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
This study derives from a developmental psychology viewpoint. The main research question is, "What are the effects of social media on children?" Aspects such as bullying, personality changes, and academic performances are considered. This topic is important because it has yet to be explored extensively. Given the ever changing nature of social media, it is a challenge to keep up with research on how this technology is changing the direction of society. Studying children involved with social media allows a direct glimpse into what one aspect of the future of child social development holds. The main problem explored in this thesis is whether or not social media is currently affecting children negatively. Correlations will be examined to determine who is most likely to utilize social media, as well as who is most likely to be affected positively or negatively by networking sites. Motivations behind social media usage and time spent online will also be studied. This research is important in understanding today's youth, and once understood, parents and teachers can learn to guide children in using social media for beneficial reasons rather than potentially detrimental ones. I have conducted my research by means of a survey, one in which the entire fifth-grade class at Copper Creek Elementary School partook. Results showed that nearly all surveyed students used social media. Differences in social media usage between classmates based on gender and presence of older siblings were found. It was concluded that social media is affecting fifth-grade females more negatively than fifth-grade males. Also, it was found that children with older siblings may be at risk for using mature social media sites too soon. The long term effects of these findings were not explored, and further research on this subject is encouraged.
ContributorsWilkey, Brooke Nicole (Author) / Lewis, Stephen (Thesis director) / Gaffney, Cynthia (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12