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- Creators: School of Social and Behavioral Sciences
Description
Vitamin D, Klotho, and FOXO3 have all been linked to have anti-aging and anti-cancerous effects as separate pathways. Specifically, mice with knockout Klotho in their genes have displayed signs of premature aging, humans who are vitamin D deficient have been shown to develop cardiovascular disease and cognitive impairments, and those who have displayed overexpression of FOXO3 have shown to have a longer lifespan. Here we took each pathway and attempted to formulate a feedback mechanism loop linking all three separate pathways. We propose that vitamin D levels modulate klotho activity, including the expression of the s-klotho and m-klotho isoforms. Moreover, the anti-oxidation transcription factor FOXO3 is also thought to participate in crosstalk with VDR signaling. Through the connection between 1,25D and Klotho, we probed at their interactions with FOXO3 signaling in kidney and colon cells, and proposed that vitamin D and klotho may reduce oxidative stress and suppress the onset of epithelial cancers through it effects on FOXO3. Results showed a strong support for the cooperation between FOXO3 and 1,25D to stimulate both superoxide dismutase (a FOXO3 response element) and XDR3/ROC (vitamin D response elements). This cooperation was mostly seen in embryonic kidney cells (HEK293) and not in the colon cancer cells (HCT116), which has led to the conclusion that vitamin D and FOXO3 cooperation mainly occurs in kidney tissue and/or in tissue that is not yet been overtaken by cancer. Differences in the Klotho isoforms were seen when measuring FOXO3 and vitamin D activity, but experiments manipulating other components will need to be conducted to further understand the function of Klotho in maintaining reactive oxygenated species levels.
ContributorsSandoval, Ruby (Author) / Jurutka, Peter (Thesis director) / Sandrin, Todd R. (Committee member) / Heck, Michael (Committee member) / School of Social and Behavioral Sciences (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Background: The prevalence of childhood obesity has disproportionately affected Latino youth and can be seen with an increase incidence of Type 2 Diabetes. This increase in obesity can be attributed to physical inactivity. Increases in social support and self-efficacy are independently related to increases in physical activity. A lifestyle intervention can lead to increases in social support, self-efficacy and physical activity. Objective/Hypothesis: The objective of this study was to determine whether a 12-week lifestyle intervention could increase social support, self-efficacy and physical activity in obese Latino adolescents that participated in the intervention. It was hypothesized that adolescents that participated in the intervention would increase self-efficacy, social support from family and friends, and physical activity compared to their control counterparts. Study Design/Participants: In a randomized control trial, there were 125 Latino (n= 60 experimental group; n= 65 control group; mean age = 15.17 +- 1.65 Males n = 60; n = 65 females) participants included in this study. Participants were also required to have a BMI percentile >= 95th percentile for age and gender or BMI >= 30 kg/m2. Methods: The intervention, which was developed using the Social Cognitive Theory had components focusing on social support and self-efficacy and also consisted of nutrition education classes and physical activity sessions for 12 weeks. The psychosocial constructs of self-efficacy and social support were measured using the Adolescent Self-Efficacy for Diet and Activity Behaviors and Adolescent Social Support for Diet and Exercise Survey, respectively. Physical activity was assessed by the 3-day Physical Activity Recall. Results: We found significant increases in social support in family (p = 0.042) and vigorous physical activity (p = 0.001). There was also a significant difference between control and treatment group for moderate to vigorous physical activity after the intervention (p = 0.027). There were no changes in social support from friends or self-efficacy. Conclusion: We concluded that a 12-week lifestyle intervention did lead to changes in social support and physical activity behaviors. These changes could have been influenced by the intervention as they were measured these constructs pre/post intervention.
ContributorsRahman, Hanna (Author) / Shaibi, Gabriel (Thesis director) / Hoffner, Kristin (Committee member) / School of Nutrition and Health Promotion (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The growth the nonprofit sector has experienced not only nationally but within the state of Arizona has been tremendous. The growth occurs one organization at a time and the research looks at the motivators as to why individuals part take in a profit less sector. The research focuses on nonprofits within Maricopa County offering human services. A combination of qualitative methods were used to guide the research. Interviews with nonprofits founders was the main form of data collection. The findings revealed self-efficacy, spirituality, and personal relations played a pivotal role as motivators for the participants. The findings also illuminated the role class, gender, and race play in the structural arrangement and opportunities to engage in adopting a nonprofit organization.
ContributorsBravo, Roberto (Co-author) / Reyes, Jaira (Co-author) / Swadener, Beth (Thesis director) / Randon, Rody (Committee member) / Barrett, The Honors College (Contributor) / School of Social Transformation (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2014-05
Description
The interplay between Post Traumatic Stress Disorder (PTSD) and self-efficacy lies in the efficacy-activated processes that comprise an individual’s cognitive and belief systems. Previous research shows that low self-efficacy contributes to development and maintenance of mental disorders like PTSD, while high self-efficacy influences ability to visualize, implement, and maintain success scenarios (resilience) related to effective mental coping. Negative cognition makes it difficult to pursue a coping success scenario in the presence of overriding self-doubt and often arises because a traumatic event has made it difficult to retrieve positive self-identities or has reactivated negative self-identities. Consistent with this model, we predict that a negative association exists between self-efficacy and PTSD onset susceptibility. We employed a pre-test/post-test design using a susceptibility/resilience questionnaire to assess predisposition to PTSD. Vignettes, designed to either raise or lower self-efficacy, were used to separate participants into groups and revealed a significant interaction between low and high self-efficacy across the pre- and post-tests, supporting the assertion that high self-efficacy guards against PTSD onset susceptibility while low self-efficacy may make someone more susceptible to developing PTSD-related symptoms.
ContributorsNightingale, Jeffrey W (Co-author) / Holloway, Steven R. (Thesis director) / Náñez, José E. (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05