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The purpose of this project is to explore the benefit of using prodrugs in chemotherapy, as well as to explain the concept of angiogenesis and the importance of this process to tumor development. Angiogenesis is the formation of new blood capillaries that are necessary for the survival of a

The purpose of this project is to explore the benefit of using prodrugs in chemotherapy, as well as to explain the concept of angiogenesis and the importance of this process to tumor development. Angiogenesis is the formation of new blood capillaries that are necessary for the survival of a tumor, as a tumor cannot grow larger than 1-2 mm3 without developing its own blood supply. Vascular disrupting agents, such as iodocombstatin, a derivative of combretastatin, can be used to effectively cut off the blood supply to a growing neoplasm, effectively inhibiting the supply of oxygen and nutrients needed for cell division Thus, VDAs have a very important implication in terms of the future of chemotherapy. A prodrug, defined as an agent that is inactive in the body until metabolized to yield the drug itself, was synthesized by combining iodocombstatin with a β-glucuronide linker. The prodrug is theoretically hydrolyzed in the body to afford the active drug by β-glucuronidase, an enzyme that is produced five times as much by cancer cells as by normal cells. This effectively creates a “magic-bullet” form of chemotherapy, known as Direct Enzyme Prodrug Therapy (DEPT).
ContributorsClark, Caroline Marie (Author) / Pettit, George Robert (Thesis director) / Melody, Noeleen (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2015-05
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Description
Currently, treatment for multiple myeloma (MM), a hematological cancer, is limited to post-symptomatic chemotherapy combined with other pharmaceuticals and steroids. Even so, the immuno-depressing cancer can continue to proliferate, leading to a median survival period of two to five years. B cells in the bone marrow are responsible for generating

Currently, treatment for multiple myeloma (MM), a hematological cancer, is limited to post-symptomatic chemotherapy combined with other pharmaceuticals and steroids. Even so, the immuno-depressing cancer can continue to proliferate, leading to a median survival period of two to five years. B cells in the bone marrow are responsible for generating antigen-specific antibodies, but in MM the B cells express mutated, non-specific monoclonal antibodies. Therefore, it is hypothesized that antibody-based assay and therapy may be feasible for detecting and treating the disease. In this project, 330k peptide microarrays were used to ascertain the binding affinity of sera antibodies for MM patients with random sequence peptides; these results were then contrasted with normal donor assays to determine the "immunosignatures" for MM. From this data, high-binding peptides with target-specificity (high fluorescent intensity for one patient, low in all other patients and normal donors) were selected for two MM patients. These peptides were narrowed down to two lists of five (10 total peptides) to analyze in a synthetic antibody study. The rationale behind this originates from the idea that antibodies present specific binding sites on either of their branches, thus relating high binding peptides from the arrays to potential binding targets of the monoclonal antibodies. Furthermore, these peptides may be synthesized on a synthetic antibody scaffold with the potential to induce targeted delivery of radioactive or chemotherapeutic molecular tags to only myelomic B cells. If successful, this would provide a novel alternative to current treatments that is less invasive, has fewer side effects, more specifically targets the cause of MM, and reliably diagnoses the cancer in the presymptomatic stage.
ContributorsBerry, Jameson (Co-author) / Buelt, Allison (Co-author) / Johnston, Stephen (Thesis director) / Diehnelt, Chris (Committee member) / School of Molecular Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Division of Teacher Preparation (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
American youth are not well exposed to animal- and nature-related careers. This is especially important to consider due to the recent push to be more environmentally conscious. In addition, youth are spending less time outside and more time in front of screens. This is driving down biophilia strength. The combination

American youth are not well exposed to animal- and nature-related careers. This is especially important to consider due to the recent push to be more environmentally conscious. In addition, youth are spending less time outside and more time in front of screens. This is driving down biophilia strength. The combination of a weaker connection with nature and more screen time has been connected to a new condition named Nature-Deficit Disorder. In order to expose youth to animal- and nature-related careers while attempting to combat the growing presence of Nature-Deficit Disorder, a three day teaching program named Wild Careers was created. This program was presented to teens in December 2015 through a partnership with the education department of Arizona Animal Welfare League. The curriculum was centered on highlighting relevant careers and background information. Topics such as animal welfare and conservation were taught as cornerstones during the program due to their encompassing importance to the career fields in question. It was felt to be important to inform participants about the context of these fields through specially planned activities and guest speakers. Participants were challenged to conduct online research, think critically, and get hands-on during this program. Wild Careers also exposed the participants to animals and the relevant species management stories. The surveys given before and after the presentation of the created curriculum provided evidence that supported an increased understanding of careers and enjoyment of participants. I propose that other non-formal teaching environments should be created that target exposing youth to animals, nature, and related careers.
ContributorsTaubel, Samantha Kay (Author) / Smith, Andrew (Thesis director) / Minteer, Ben (Committee member) / Arthur, Emilie (Committee member) / Division of Teacher Preparation (Contributor) / School of Sustainability (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The purpose of this project was prove that animated characters have a unique appeal to the empathy of viewers, and to then create assets that could be used in an effective way to spread awareness about endangered species. I sought to explore in what ways animation connects to individuals, and

The purpose of this project was prove that animated characters have a unique appeal to the empathy of viewers, and to then create assets that could be used in an effective way to spread awareness about endangered species. I sought to explore in what ways animation connects to individuals, and how those connections can be used to create empathy towards endangered animal species. I created two surveys as a way of measuring the connections between participants and the elements of two videos about wildlife conservation; one animated and one live-action. After surveying over 130 people, I found that the video with animated animal characters evoked strong emotions from 82.5% of participants. This, combined with participant interest in other elements such as color and animated style, prompted me to create two animal characters that could be used for educational animated short films. I created character designs for a Galapagos penguin and a black-horned rhinoceros, 3D modeled environments, a storyboard and script for a short video featuring the rhinoceros, and a 3D model and animated walk-cycle for the penguin. These elements were created with the idea that they could be used in order to create educational animated videos about endangered species. The biggest takeaway from this project is that while the aesthetics and characters of animation are important to viewers, it is also important that they are able to learn not only about the endangered species, but how they can contribute to wildlife conservation.
ContributorsOlson, Grace Hannah (Author) / Button, Melissa M (Thesis director) / Cala, Coats (Committee member) / Division of Teacher Preparation (Contributor) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Description
As the public becomes increasingly aware of the morality of wildlife institutions like zoos and aquariums, these places are now having to face possible negativity and lack of support from their communities. In light of this, these institutions are now focusing their goals and efforts towards conservation education and outreach

As the public becomes increasingly aware of the morality of wildlife institutions like zoos and aquariums, these places are now having to face possible negativity and lack of support from their communities. In light of this, these institutions are now focusing their goals and efforts towards conservation education and outreach programs in order to continue contributing to biodiversity conservation. Research has proven that wildlife institutions like zoos and aquariums are effective ways to teach the community about wildlife and conservation. To measure how effective aquariums are at educating their patrons on conservation, a short survey was administered to 100 patrons of the OdySea Aquarium in Scottsdale, Arizona. The object of the survey was to assess which type of conservation messaging was preferred by the general public and if patrons of the aquarium were likely to engage in pro-conservation behaviors after their visit. It was found that the majority of respondents preferred interactive exhibits as their choice to learn about conservation and wildlife. In addition, almost all respondents agreed that they would continue practicing behaviors that supported pro-conservation actions after their visit to the aquarium. My results also showed that patrons of the aquarium were well educated about plastic pollution and the rehabilitation that OdySea accomplishes for the sea turtles due to their overexpression of mentioning plastic in their open-ended questions. My findings indicate that this aquarium is succeeding in promoting conservation and wildlife education as well as supporting cultivation within their patrons that will benefit the future health of this planet.
ContributorsErhardt, Jordan Hanna (Author) / Schuster, Roseanne (Thesis director) / Cheng, Samantha (Committee member) / School of Life Sciences (Contributor) / Division of Teacher Preparation (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05