Matching Items (10)
Filtering by
Description
It is presently believed that brown adipose tissue (BAT) is an important tissue in the control of obesity because it has the propensity to increase energy expenditure. The purpose of this study was to attempt to quantify the thermogenesis of BAT when four rats were exposed to a progression of low-fat to high-fat diet. Exogenous norepinephrine (NE) injections (dose of 0.25 mg/kg i.p.) were administered in order to elicit a temperature response, where increases in temperature indicate increased activity. Temperatures were measured via temperature sensing transponders that had been inserted at the following three sites: interscapular BAT (iBAT), the abdomen (core), and lower back (reference). Data showed increased BAT activity during acute (2-3 weeks) high fat diet (HFD) in comparison to low fat diet (LFD), but a moderate to marked decrease in BAT activity during chronic HFD (6-8 weeks) when compared to acute HFD. This suggests that while a HFD may initially stimulate BAT in the short-term, a long-term HFD diet may have negative effects on BAT activation.
ContributorsSivak, Hanna (Author) / Sweazea, Karen (Thesis director) / Herman, Richard (Committee member) / Caplan, Michael (Committee member) / School of Life Sciences (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Token economies are a type of behavioral reinforcement that are particularly useful in classroom settings for increasing student compliance, for both typically developing children and children with autism spectrum disorder. During this study, we implemented a token economy in an inclusive preschool classroom with tokens contingent on compliance to classroom rules. Three participants, two with a diagnosis of autism spectrum disorder and one considered typically developing, were included in the study. Results indicated that levels of compliance increased for both the typically developing participant and participants with autism, and did not drop below baseline levels during the withdrawal phase, suggesting there was no lack of intrinsic motivation. Further, the typically developing participant and one of the participants with autism spectrum disorder had very similar levels of compliance, while the other participant had much higher levels of compliance throughout every phase, suggesting that the compliance levels for peers with more advanced repertoires with autism may differ from both typically developing peers and peers who have less developed repertoires. The implications of these results are discussed as they relate to compliance from an ABA perspective.
ContributorsEggen, Kelly (Author) / Hahs, Adam (Thesis director) / Cavanaugh Toft, Carolyn (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Adults with autism spectrum disorder (ASD) commonly have co-morbid psychiatric symptoms which can decrease quality of life. Although many adults with ASD are achieving greater independence, including attending college, psychiatric symptoms are generally not well controlled in this group. Mindfulness Based Stress Reduction (MBSR) is a program that has successfully been used to reduce the stress, depression, and anxiety symptoms in many clinical and non-clinical groups and may also be effective for college-aged students with ASD. The present investigation assessed the demand, practicality, implementation, adaptation, and acceptability of an MBSR course for college students with ASD. A total of 22 participants completed the questionnaire containing 53 questions and were between the ages of 18 to 64. We found that the MBSR therapy is in high demand for individuals with ASD, and that the participants would be willingly complete the intervention techniques. Participants generally stated that a therapy course like MBSR may help reduce their symptoms, and that they were eager to enroll. Participants were willing to attend all 8 classes during the summer, with a preference for afternoons. Also, modifications including yoga and background music would be accepted by each participant as well as any additional modifications made to the course to meet the needs of the individuals with ASD. Next steps include enrolling and randomizing students into the MBSR course or control group, as well as collect pre- and post-intervention data. We hypothesize MBSR will reduce the psychiatric symptoms and stress levels of individuals in college with ASD, demonstrating its effectiveness in this vulnerable population.
ContributorsJones, Rachel Michelle (Author) / Braden, Blair (Thesis director) / Baxter, Leslie (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Department of Speech and Hearing Science (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This research addresses the importance of factors such as gestational weight gain (GWG) and postpartum weight of mothers, as well as obesity rates in infants born to these mothers who are included in the population of low-income Mexican-American mothers and infants enrolled in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). Evaluating these factors will contribute to finding recommendations to help solve the obesity epidemic in this specific population. Breastfeeding duration, mother BMI, infant birth weight, and infant weight z-scores were statistically analyzed from a WIC population in Houston. The study participants are involved in a five year intervention study where the home environment and education on feeding practices, breastfeeding duration and obesity are evaluated. The results found that: (1) breastfeeding initially indicates a further continuation of breastfeeding; (2) mothers who breastfed for six months were likely to have a lower BMI at twelve to eighteen months than those who did not; (3) the birth weight of the infant is associated with the weight pattern of the child later; (4) the weight/height percentiles of a newborn are somewhat likely to stay the same until age three; (5) the prenatal weight of the mother impacts the weight of the newborn infant; and (6) the mother's postpartum BMI at one week is associated with a similar BMI at 12 months postpartum. In conclusion, women in this population tend to not breastfeed for 6 months and are not losing gestational weight postpartum, leading to increased wright retention after pregnancy, as well as heavier babies that will maintain this weight in early childhood. Further breastfeeding, nutrition, exercise, obesity, and proper infant feeding education are needed to reduce the rate of obesity in low-income Mexican-American WIC populations.
ContributorsSchmid, Emily Grace (Author) / Reifsnider, Elizabeth (Thesis director) / Danielson, Kim (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
The purpose of this project was to research the expression of Autism Spectrum Disorder in children and create a children’s book that can help the peers of individuals with a diagnosis to understand what the disorder entails and potentially gain a new sense of empathy for peers of all levels of physical and mental abilities. The research component includes interviews with individuals deemed knowledgeable about ASD, including occupational therapists, behavioral analysts, and parents, as well as a literature review of research studies on the expression of Autism in children. This written portion of the project may also serve as a manual for individuals who have little to no knowledge of ASD, as it dives deeper into the content of the book and research, while remaining easily understandable and clear to those without any prior knowledge or experience with ASD. It could prove especially useful for those in professions that come into contact with individuals with Autism, but do not necessarily require psychology courses or training as a prerequisite for the role, such as teachers and some health professionals.
ContributorsSigna, Hope (Author) / Nelson, Elizabeth (Thesis director) / Spinrad, Tracy (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
This research paper covers many topics related to autism, including causes, treatment, DSM changes, and more. It is a review of current literature and journals and aims to give the audience a better understanding of the disorders and to discuss the changes in diagnostic criteria and prevalence of ASD.
ContributorsPeters, Emily Morgan (Author) / Stenhoff, Donald (Thesis director) / Hahs, Adam (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
The goal of this study was to gain insights from adults on the autism spectrum regarding their recommendations for improving the accessibility of stores and restaurants. Four adults who indicated that they had a diagnosis of autism spectrum disorder or Asperger’s Syndrome volunteered to participate in a qualitative interview. The questions that participants were asked centered around their experiences in stores and restaurants, current accessibility guidelines, the impact of COVID-19 on their experiences, and their recommendations for increased accessibility. Recommendations fell into two main categories: changes to the environment and accommodations that could be provided. Participants suggested multiple ways to reduce their sensitivities to noise in stores and restaurants like lowering the music, creating a quiet hour, or providing noise cancelling headphones. Further efforts are needed to fully understand the issue of accessibility for autistic individuals.
ContributorsWall, Charlotte (Author) / Updegraff, Kimberly (Thesis director) / Puruhito, Krista (Committee member) / Barrett, The Honors College (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / School of Criminology and Criminal Justice (Contributor)
Created2021-12
Description
Preliminary studies indicate that the use of dietary menthol may prevent excessive weight gain through the activation of the transient receptor potential melastatin family member 8 (TRPM8) ion channel. It has also been expressed that elevation of the core temperature (Tc) inducing mild hyperthermia via an increase in ambient temperature aids in a marked reduction of the drive to eat and weight gain. While caloric restriction (CR) aims to treat obesity and secondary sicknesses, weight regain is a common result during long term weight maintenance. The goal of these studies was to evaluate and identify if the menthol and mild hyperthermia mechanisms could couple synergistically to reduce or abrogate weight gain. Ambient temperature (Ta) was increased incrementally to identify the threshold in which rodents display mild hyperthermia. Our initial attempts at hyperthermia induction failed because of limitations in the environmental chamber. These trials fail to note a threshold at which elevated Tc is sustained for any period of time. The data suggests an ambient temperature of 36-38 °C would be appropriate to induce a mild hyperthermia. A mild hyperthermia is described as the elevation of Tc 2-3 ° above the hypothalamic set point. To facilitate future hyperthermia studies, an environmental chamber was designed. A wine cooler was converted to withstand the desired temperatures, through the use of heat tape, a proportional controller, and a translucent Plexiglas custom fit door. Beyond leveraging temperature to regulate weight gain, dietary changes including a comparison between standard chow food, high fat diet, and menthol supplemented chow food treatment illustrate a strong likelihood of weight gain variability. In this pilot study, weight gain expression when given a diet supplemented with menthol (1%) showed no statistical significance relative to a high fat diet nor chow food, however, it revealed a trend of reduced weight gain. It is assumed the combination of supplemental menthol and mild hyperthermia induction will exacerbate their effects.
ContributorsJohnsson, Kailin Alexis (Author) / Van Horn, Wade (Thesis director) / Herman, Richard (Committee member) / Towe, Bruce (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of Life Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Diabesity is a global epidemic affecting millions worldwide. Diabesity is the term given to the link between obesity and Type II diabetes. It is estimated that ~90% of patients diagnosed with Type II diabetes are overweight or have struggled with excess body fat in the past. Type II diabetes is characterized by insulin resistance which is an impaired response of the body to insulin that leads to high blood glucose levels. Adipose tissue, previously thought of as an inert tissue, is now recognized as a major endocrine organ with an important role in the body's immune response and the development of chronic inflammation. It is speculated that adipose tissue inflammation is a major contributor to insulin resistance particular to Type II diabetes. This literature review explores the popular therapeutic targets and marketed drugs for the treatment of Type II diabetes and their role in decreasing adipose tissue inflammation. rAGE is currently in pre-clinical studies as a possible target to combat adipose tissue inflammation due to its relation to insulin resistance. Metformin and Pioglitazone are two drugs already being marketed that use unique chemical pathways to increase the production of insulin and/or decrease blood glucose levels. Sulfonylureas is one of the first FDA approved drugs used in the treatment of Type II diabetes, however, it has been discredited due to its life-threatening side effects. Bariatric surgery is a form of invasive surgery to rid the body of excess fat and has shown to normalize blood glucose levels. These treatments are all secondary to lifestyle changes, such as diet and exercise which can help halt the progression of Type II diabetes patients.
ContributorsRobles, Alondra Maria (Author) / Woodbury, Neal (Thesis director) / Redding, Kevin (Committee member) / Allen, James (Committee member) / Hendrickson, Kirstin (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that not only affects communication and behavior with often co-occurring gastrointestinal (GI) issues such as constipation and diarrhea. Recent studies have shown that many GI and behavioral symptoms in individuals with ASD are linked to dysregulated immune systems and altered gut microbiomes (bacteria and fungi). In fungal microbiota, a common GI commensal and opportunistic pathogen, Candida, has been found in higher abundance in children with ASD. Few studies have investigated total IgA and IgG levels in both blood and feces of ASD individuals with relatively mixed findings, showing either significantly higher or lower IgG and IgA abundance in ASD vs. TD (typically developing) individuals. Mixed results are likely due to a lack of a standardized method of immunoglobulin (Ig) quantification. In this study, we attempt to standardize an enzyme-linked immunoassay (ELISA) procedure to measure total IgA, total IgG, and anti-Candida albicans IgA and IgG levels in fecal samples of adults with ASD. Measuring Ig levels can reflect altered gut microbiota, GI tract, and immune status in ASD and potentially characterize Ig as a biomarker for ASD. Although we were unable to successfully standardize an Ig ELISA quantification method, SDS-PAGE confirmed the presence of IgA in fecal Ig extracts. Based on our ELISA results, we suspect that dilution factors of fecal Ig extracts need to be modified further to detect the IgA within the detection range. The experimental methodology in this study can be used as a reference to develop and improve a full-proof method of quantifying immunoglobulin from ASD fecal samples, which will help to reveal immune status in ASD.
ContributorsCampos, Nicole (Author) / Marwah, Mira (Co-author) / Krajmalnik-Brown, Rosa (Thesis director) / Nirmalkar, Khemlal (Committee member) / Barrett, The Honors College (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / School of Life Sciences (Contributor)
Created2022-05