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Description
Cardiovascular disease (CVD) is the number one cause of death in the United States and type 2 diabetes (T2D) and obesity lead to cardiovascular disease. Obese adults are more susceptible to CVD compared to their non-obese counterparts. Exercise training leads to large reductions in the risk of CVD and T2D.

Cardiovascular disease (CVD) is the number one cause of death in the United States and type 2 diabetes (T2D) and obesity lead to cardiovascular disease. Obese adults are more susceptible to CVD compared to their non-obese counterparts. Exercise training leads to large reductions in the risk of CVD and T2D. Recent evidence suggests high-intensity interval training (HIT) may yield similar or superior benefits in a shorter amount of time compared to traditional continuous exercise training. The purpose of this study was to compare the effects of HIT to continuous (CONT) exercise training for the improvement of endothelial function, glucose control, and visceral adipose tissue. Seventeen obese men (N=9) and women (N=8) were randomized to eight weeks of either HIT (N=9, age=34 years, BMI=37.6 kg/m2) or CONT (N=8, age=34 years, BMI=34.6 kg/m2) exercise 3 days/week for 8 weeks. Endothelial function was assessed via flow-mediated dilation (FMD), glucose control was assessed via continuous glucose monitoring (CGM), and visceral adipose tissue and body composition was measured with an iDXA. Incremental exercise testing was performed at baseline, 4 weeks, and 8 weeks. There were no changes in weight, fat mass, or visceral adipose tissue measured by the iDXA, but there was a significant reduction in body fat that did not differ by group (46±6.3 to 45.4±6.6%, P=0.025). HIT led to a significantly greater improvement in FMD compared to CONT exercise (HIT: 5.1 to 9.0%; CONT: 5.0 to 2.6%, P=0.006). Average 24-hour glucose was not improved over the whole group and there were no group x time interactions for CGM data (HIT: 103.9 to 98.2 mg/dl; CONT: 99.9 to 100.2 mg/dl, P>0.05). When statistical analysis included only the subjects who started with an average glucose at baseline > 100 mg/dl, there was a significant improvement in glucose control overall, but no group x time interaction (107.8 to 94.2 mg/dl, P=0.027). Eight weeks of HIT led to superior improvements in endothelial function and similar improvements in glucose control in obese subjects at risk for T2D and CVD. HIT was shown to have comparable or superior health benefits in this obese sample with a 36% lower total exercise time commitment.
ContributorsSawyer, Brandon J (Author) / Gaesser, Glenn A (Thesis advisor) / Shaibi, Gabriel (Committee member) / Lee, Chong (Committee member) / Swan, Pamela (Committee member) / Buman, Matthew (Committee member) / Arizona State University (Publisher)
Created2013
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Description
Nut consumption, specifically almonds, have been shown to help maintain weight and influence disease risk factors in adult populations. Limited studies have been conducted examining the effect of a small dose of almonds on energy intake and body weight. The objective of this study was to determine the influence of

Nut consumption, specifically almonds, have been shown to help maintain weight and influence disease risk factors in adult populations. Limited studies have been conducted examining the effect of a small dose of almonds on energy intake and body weight. The objective of this study was to determine the influence of pre-meal almond consumption on energy intake and weight in overweight and obese adults. In this study included 21, overweight or obese, participants who were considered healthy or had a controlled disease state. This 8-week parallel arm study, participants were randomized to consume an isocaloric amount of almonds, (1 oz) serving, or two (2 oz) cheese stick serving, 30 minutes before the dinner meal, 5 times per week. Anthropometric measurements including weight, waist circumference, and body fat percentage were recorded at baseline, week 1, 4, and 8. Measurement of energy intake was self-reported for two consecutive days at week 1, 4 and 8 using the ASA24 automated dietary program. The energy intake after 8 weeks of almond consumption was not significantly different when compared to the control group (p=0.965). In addition, body weight was not significantly reduced after 8 weeks of the almond intervention (p=0.562). Other parameters measured in this 8-week trial did not differ between the intervention and the control group. These data presented are underpowered and therefore inconclusive on the effects that 1 oz of almonds, in the diet, 5 per week has on energy intake and bodyweight.
ContributorsMcBride, Lindsey (Author) / Johnston, Carol (Thesis advisor) / Swan, Pamela (Committee member) / Mayol-Kreiser, Sandra (Committee member) / Arizona State University (Publisher)
Created2011
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Description
Introduction: Several faith-based or faith-placed programs have focused on the physical dimension of wellness in efforts to improve health by increasing physical activity and improving diet behaviors. However, these programs were not designed to intervene on the mental dimension of wellness which is critical for stress reduction and health behavior

Introduction: Several faith-based or faith-placed programs have focused on the physical dimension of wellness in efforts to improve health by increasing physical activity and improving diet behaviors. However, these programs were not designed to intervene on the mental dimension of wellness which is critical for stress reduction and health behavior change. Purpose: To evaluate the feasibility of a spirituality-based stress reduction and health behavior change intervention using the Spiritual Framework of Coping (SFC) model. Methods: This study was a quasi-experimental one group pretest posttest design. The study was a total of eight weeks conducted at a non-denominational Christian church. Participants were recruited from the church through announcements and flyers. The Optimal Health program met once a week for 1.5 hours with weekly phone calls during an additional four week follow-up period. Feasibility was assessed by the acceptability, demand, implementation, practicality, integration, and limited efficacy of the program. Analysis: Frequencies for demographics were assessed. Statistical analyses of feasibility objectives were assessed by frequencies and distribution of responses to feasibility evaluations. Limited efficacy of pretest and posttest measures were conducted using paired t-test (p <.05). Results: The Optimal Health Program was positively accepted by participants. The demand for the program was shown with average attendance of 78.7%. The program was successfully implemented as shown by meeting session objectives and 88% homework completion. The program was both practical for the intended participants and was successfully integrated within the existing environment. Limited efficacy changes within the program were mostly non-significant. Conclusion: This study tested the feasibility of implementing the Optimal Health program that specifically targeted the structural components of the Spiritual Framework of Coping Model identified to create meaning making and enhance well-being. This program may ultimately be used to help individuals improve and balance the spiritual, mental, and physical dimensions of wellness. However, length of study and limited efficacy measures will need to be reevaluated for program success.
ContributorsWalker, Jenelle R (Author) / Swan, Pamela (Thesis advisor) / Ainsworth, Barbara (Committee member) / Chisum, Jack (Committee member) / Fleury, Julie (Committee member) / Hooker, Steven (Committee member) / Arizona State University (Publisher)
Created2012
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Description
PURPOSE: Lean hypertension (HTN) is characterized by a mechanistically different HTN when compared to obese HTN. The purpose of this study is to assess whether body phenotype influences blood pressure (BP) responses following both acute and chronic exercise. METHODS: Obese (body mass index (BMI) > 30 kg/m2) and

PURPOSE: Lean hypertension (HTN) is characterized by a mechanistically different HTN when compared to obese HTN. The purpose of this study is to assess whether body phenotype influences blood pressure (BP) responses following both acute and chronic exercise. METHODS: Obese (body mass index (BMI) > 30 kg/m2) and lean (BMI < 25 kg/m2) men with pre-hypertension (PHTN) (systolic BP (SBP) 120 - 139 or diastolic BP (DBP) 80 - 89 mm Hg) were asked to participate in a two-phase trial. Phase 1 assessed differences in post-exercise hypotension between groups in response to an acute exercise bout. Phase 2 consisted of a two-week aerobic exercise intervention at 65-70% of heart rate (HR) max on a cycle ergometer. Primary outcome measures were: brachial BP, central (aortic) BP, cardiac output (CO), and systemic vascular resistance (SVR) measured acutely after one exercise session and following two weeks of training. RESULTS: There were no differences between groups for baseline resting brachial BP, central BP, age, or VO2 peak (all P > 0.05). At rest, obese PHTN had greater CO compared to lean PHTN (6.3 ± 1 vs 4.7 ± 1 L/min-1, P = 0.005) and decreased SVR compared to lean PHTN (1218 ± 263 vs 1606 ± 444 Dyn.s/cm5, P = 0.003). Average 60-minute post-exercise brachial and central SBP reduced by 3 mm Hg in Lean PHTN in response to acute exercise (P < 0.005), while significantly increasing 4 mm Hg for brachial and 3 mm Hg for central SBP (P < 0.05). SVR had a significantly greater reduction following acute exercise in lean PHTN (-223 Dyn·s/cm5) compared to obese PHTN (-75 Dyn·s/cm5, P < 0.001). In lean subjects chronic training reduced brachial BP by 4 mm Hg and central BP by 3 mm Hg but training had no effect on the BP’s in obese subjects. Resting BP reduction in response to training was accompanied by reductions in SVR within lean (-169 Dyn·s/cm5, P < 0.001), while obese experienced increased SVR following training (47 Dyn·s/cm5, P < 0.001). CONCLUSION: Hemodynamic response to both acute and chronic exercise training differ between obese and lean individuals.
ContributorsZeigler, Zachary (Author) / Swan, Pamela (Thesis advisor) / Gaesser, Glenn (Committee member) / Buman, Matthew (Committee member) / Angadi, Siddhartha (Committee member) / Farouk, Mookadam (Committee member) / Arizona State University (Publisher)
Created2016
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Description
Having accurate measurements of sedentary behaviors is important to understand relationships between sedentary behaviors and health outcomes and to evaluate changes in interventions and health promotion programs designed to reduce sedentary behaviors. This dissertation included three projects that examined measurement properties of wearable monitors used to measure sedentary behaviors. Project

Having accurate measurements of sedentary behaviors is important to understand relationships between sedentary behaviors and health outcomes and to evaluate changes in interventions and health promotion programs designed to reduce sedentary behaviors. This dissertation included three projects that examined measurement properties of wearable monitors used to measure sedentary behaviors. Project one examined the validity of three monitors: the ActiGraph GT3X+, activPAL™, and SenseWear 2. None of the monitors were equivalent with the criterion measure of oxygen uptake to estimate the energy cost of sedentary and light-intensity activities. The ActivPAL™ had the best accuracy as compared with the other monitors. In project two, the accuracy of ActiGraph GT3X+and GENEActiv cut-points used to assess sedentary behavior were compared with direct observation during free-living conditions. New vector magnitude cut-points also were developed to classify time spent in sedentary- and stationary behaviors during free-living conditions. The cut-points tested had modest overall accuracy to classify sedentary time as compared to direct observation. New ActiGraph 1-minute vector cut-points increased overall accuracy for classifying sedentary time. Project 3 examined the accuracy of the sedentary sphere by testing various arm elevation- and movement-count configurations using GENEActiv and ActiGraph GT3X+ data obtained during free-living conditions. None of the configurations were equivalent to the criterion measure of direct observation. The best configuration of the GENEActiv was: worn on the dominant wrist at 15 degrees below the horizontal plane with a cut-point <489 for each 15-second interval. The best configuration for the ActiGraph was: worn on the non-dominant wrist at 5° below the horizontal plane with a cut-point of <489 counts for each 15-second interval. Collectively, these findings indicate that the wearable monitors and methods examined in this study are limited in their ability to assess sedentary behaviors and light intensity physical activity. Additional research is needed to further understand the scope and limitations of wearable monitors and methods used to assess sedentary behaviors and light intensity physical activity.
ContributorsFlorez Pregonero, Argemiro Alberto (Author) / Ainsworth, Barbara E (Thesis advisor) / Buman, Matthew P (Committee member) / Hooker, Steven P (Committee member) / Keller, Colleen S (Committee member) / Swan, Pamela (Committee member) / Arizona State University (Publisher)
Created2017
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Description
Obesity is currently a prevalent health concern in the United States. Essential to combating it are accurate methods of assessing individual dietary intake under ad libitum conditions. The acoustical monitoring system (AMS), consisting of a throat microphone and jaw strain sensor, has been proposed as a non-invasive method for tracking

Obesity is currently a prevalent health concern in the United States. Essential to combating it are accurate methods of assessing individual dietary intake under ad libitum conditions. The acoustical monitoring system (AMS), consisting of a throat microphone and jaw strain sensor, has been proposed as a non-invasive method for tracking free-living eating events. This study assessed the accuracy of eating events tracked by the AMS, compared to the validated vending machine system used by the NIDDK in Phoenix. Application of AMS data toward estimation of mass and calories consumed was also considered. In this study, 10 participants wore the AMS in a clinical setting for 24 hours while all food intake was recorded by the vending machine. Results indicated a correlation of 0.76 between number of eating events by the AMS and the vending machine (p = 0.019). A dependent T-test yielded a p-value of 0.799, illustrating a lack of significant difference between these methods of tracking intake. Finally, number of seconds identified as eating by the AMS had a 0.91 correlation with mass of intake (p = 0.001) and a 0.70 correlation with calories of intake (p = 0.034). These results indicate that the AMS is a valid method of objectively recording eating events under ad libitum conditions. Additional research is required to validate this device under free-living conditions.
ContributorsSteinke, Amanda (Author) / Johnston, Carol (Thesis advisor) / Votruba, Susanne (Committee member) / Hall, Richard (Committee member) / Arizona State University (Publisher)
Created2013