Matching Items (40)
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To address the international Human Immunodeficiency Virus epidemic, the World Health Organization, or WHO, developed three drug treatment regimens between 2010 and 2012 specifically for HIV-positive pregnant women and their infants. WHO developed the regimens, calling them Option A, Option B, and Option B+, to reduce or prevent mother-to-child, abbreviated

To address the international Human Immunodeficiency Virus epidemic, the World Health Organization, or WHO, developed three drug treatment regimens between 2010 and 2012 specifically for HIV-positive pregnant women and their infants. WHO developed the regimens, calling them Option A, Option B, and Option B+, to reduce or prevent mother-to-child, abbreviated MTC, transmission of HIV. Each option comprises of different types and schedules of antiretroviral medications. As of 2018, WHO reported that in Africa alone about 1,200,000 pregnant women were living with untreated HIV. Those women have up to a forty-five percent chance of transmitting HIV to their offspring if they do not receive treatment. Option B+ has decreased the overall maternal mortality rates in many low- and middle-income countries, and numerous studies have supported the notion that it is the most effective of the three regimens for preventing MTC transmission of HIV.

Created2021-03-01
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In 2018, researchers Elie Nkwabong, Romuald Meboulou Nguel, Nelly Kamgaing, and Anne Sylvie Keddi Jippe published, “Knowledge, Attitudes, and Practices of Health Personnel of Maternities in the Prevention of Mother-To-Child Transmission of HIV in a sub-Saharan African Region with High Transmission Rate: Some Solutions Proposed,” in BMC Pregnancy and Childbirth.

In 2018, researchers Elie Nkwabong, Romuald Meboulou Nguel, Nelly Kamgaing, and Anne Sylvie Keddi Jippe published, “Knowledge, Attitudes, and Practices of Health Personnel of Maternities in the Prevention of Mother-To-Child Transmission of HIV in a sub-Saharan African Region with High Transmission Rate: Some Solutions Proposed,” in BMC Pregnancy and Childbirth. In their article, hereafter “Knowledge, Attitudes, and Practices,” the authors state the aim of their study was to establish the knowledge, attitudes, and practices held by health professionals who worked in numerous maternal departments throughout Cameroon. They claimed that effective knowledge, attitudes, and practices would likely reduce mother-to-child, hereafter MTC, transmission of HIV. After finding a deficit in the knowledge, attitudes, and practices among a subset of health professionals, the authors recommended increased training, funding, and supervision to reduce MTC transmission of HIV throughout Cameroon.

Created2021-04-06
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In 1999, the Inter-agency Working Group on Reproductive Health in Crises, hereafter the IAWG, wrote the Minimum Initial Services Package, hereafter MISP, which is the second chapter in Reproductive Health in Refugee Situations: An Inter-agency Field Manual. The IAWG wrote MISP for governments and agencies, who respond to humanitarian crises,

In 1999, the Inter-agency Working Group on Reproductive Health in Crises, hereafter the IAWG, wrote the Minimum Initial Services Package, hereafter MISP, which is the second chapter in Reproductive Health in Refugee Situations: An Inter-agency Field Manual. The IAWG wrote MISP for governments and agencies, who respond to humanitarian crises, as a guide for the provision of reproductive health services at the beginning of a humanitarian crises. The goal of MISP was to outline the services that people in humanitarian crises are to receive to minimize injury and death from complications related to reproductive health, prevent and manage the consequences of sexual violence, and reduce the transmission of sexually transmitted infections, or STIs. MISP recognizes that reproductive health is a human right and applies to people in humanitarian crises, providing specific details for governments and agencies to follow and mitigate the adverse effects of reproductive health issues in vulnerable populations.

Created2021-01-18
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Thalidomide, a drug capable of causing fetal abnormalities (teratogen), has caused greater than ten thousand birth defects worldwide since its introduction to the market as a pharmaceutical agent. Prior to discovering thalidomide's teratogenic effects in the early 1960s, the US Food and Drug Administration (FDA) did not place regulations on

Thalidomide, a drug capable of causing fetal abnormalities (teratogen), has caused greater than ten thousand birth defects worldwide since its introduction to the market as a pharmaceutical agent. Prior to discovering thalidomide's teratogenic effects in the early 1960s, the US Food and Drug Administration (FDA) did not place regulations on drug approval or monitoring as it later did. By 1962, approximately 20,000 patients in the US had taken thalidomide as part of an unregulated clinical trial before any actions were taken to stop thalidomide's distribution. Due to thalidomide's effects on fetuses, both nationally and abroad, the US Congress passed the 1962 Kefauver-Harris Amendments to the 1938 Food, Drug, and Cosmetic Act. These amendments imposed guidelines for the process of drug approval in the US and required that a drug be safe as well as effective before it could be approved and marketed. Thalidomide also influenced the FDA's creation of pregnancy categories; a ranking of drugs based on their effects on reproduction and pregnancy. Thalidomide motivated the laws on regulating and monitoring drugs developed in the US and by the FDA in the twentieth and twenty-first centuries.

Created2014-04-01
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Ian Hector Frazer studied the human immune system and vaccines in Brisbane, Australia, and helped invent and patent the scientific process and technology behind what later became the human papillomavirus, or HPV, vaccinations. According to the Centers for Disease Control and Prevention of the US, or CDC, HPV is the

Ian Hector Frazer studied the human immune system and vaccines in Brisbane, Australia, and helped invent and patent the scientific process and technology behind what later became the human papillomavirus, or HPV, vaccinations. According to the Centers for Disease Control and Prevention of the US, or CDC, HPV is the most common sexually transmitted infection, and can lead to genital warts, as well as cervical, head, mouth, and neck cancers. Frazer and virologist Jian Zhou conducted research in the 1990s to assess why women with HPV had higher rates of precancerous and cancerous cervical cells. Frazer’s research led the pharmaceutical company Merck to produce the Gardasil vaccination series, and GlaxoSmithKline to produce the Cervarix vaccination. Frazer’s research contributed to the development of HPV vaccinations that have been successful in reducing up to seventy percent of cervical cancer cases in women.

Created2020-09-02
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Background: In 2012 the U.S. Food and Drug Administration (FDA) approved the drug emtricitabine/tenofovir for use as Human Immunodeficiency Virus (HIV) pre-exposure prophylaxis (PrEP) after proving to be safe and effective at preventing HIV in multiple peer-reviewed studies. Despite the proven safety and value of PrEP treatment, use remains low

Background: In 2012 the U.S. Food and Drug Administration (FDA) approved the drug emtricitabine/tenofovir for use as Human Immunodeficiency Virus (HIV) pre-exposure prophylaxis (PrEP) after proving to be safe and effective at preventing HIV in multiple peer-reviewed studies. Despite the proven safety and value of PrEP treatment, use remains low in practice. Research has shown that low clinical use corresponds to low levels of understanding of PrEP among providers. Academic detailing is a method of innovation diffusion through provider education that results in changes in knowledge and practice. The purpose of this project was to investigate the effects of academic detailing on primary care provider knowledge, attitudes, and willingness to prescribe PrEP.

Methods: An academic detailing session was provided by the Florida Department of Health in Broward County to primary care providers (PCPs) at a private clinic in the Southeastern US. The Conceptual Model of Nursing and Population Health (CMNPH) and the Promoting Action on Research Implementation in Health Services Framework (PARIHS) were used as guides for project design and evidence-based practice implementation. There were five participants in the academic detailing session including: a physician, a physician assistant (PA), and three medical students. PCP PrEP knowledge, attitudes, and behaviors were measured using pre and post intervention surveys. PrEP prescription, HIV/Sexually Transmitted Infection (STI) screening, and HIV testing were measured using aggregate data queries for the time periods of four and eight weeks before and four and eight weeks after the educational intervention. No personal identifying information was obtained.

Results: Pre and post surveys were analyzed using Wilcoxon signed rank testing to examine differences between matched pairs of ordinal data. Significant PrEP screening and HIV/STI testing were analyzed pre and post intervention using paired t tests to compare pre and post intervention practices. Significant differences were found in the results (Z = 2.03, 1.84, and 1.83 respectively, p > 0.1) The academic detailing intervention significantly improved knowledge, attitudes, and behaviors of primary care providers and medical students regarding PrEP. The mean of active qualifying ICD 10 codes prior to the intervention versus post intervention were 5 (sd = 5.64) vs. 4.2 (sd = 4.87) respectively. No significant difference was found between active ICD 10 codes for patient visits before compared to after the intervention (t (9) = 1.12, p>.1).

Conclusions: This project found that academic detailing improved provider self-reported knowledge, attitudes, and behaviors regarding PrEP. However, self-reported survey scores were not correlated with changes in clinical practice based on ICD 10 codes. Additional clinical implications may include fostering clinical outreach and cooperation between the county health department and local primary care clinics. Further research is needed on the effects of PrEP academic detailing on clinical practice.
ContributorsSchlumbrecht, Benjamin (Author) / Link, Denise (Thesis advisor)
Created2018-04-18
Description

Human Immunodeficiency Virus (HIV) and acquired immunodeficiency syndrome (AIDS) are diseases that still pose a threat to all parts of the world, particularly in less economically developed regions. However, it continues to be a problem in many high-income countries. The epidemiological picture in Spain offers an interesting case study for

Human Immunodeficiency Virus (HIV) and acquired immunodeficiency syndrome (AIDS) are diseases that still pose a threat to all parts of the world, particularly in less economically developed regions. However, it continues to be a problem in many high-income countries. The epidemiological picture in Spain offers an interesting case study for analysis to answer whether local interventions to confront HIV transmission, morbidity, and mortality are more effective than solely national or international efforts to reduce the effects of the disease. In this thesis, I rely on qualitative data in the form of key informant interviews and field notes collected in Barcelona, Spain, to demonstrate the significant role that grassroots organizations play in combating HIV in the Spanish context. CheckPoint Barcelona and ACATHI are two organizations in Barcelona, Spain that seek to improve such outcomes by directly providing support for communities at risk of poor outcomes after a late diagnosis of HIV and of contracting HIV in general. I find that local, non-governmental organizations are the driving force in combating HIV in Spain through three approaches: biomedical interventions, education and prevention initiatives, and social support for affected communities. Collectively, these findings suggest that non-governmental organizations, like ACATHI and CheckPoint should be supported to continue achieving desired HIV objectives.

ContributorsDecker, Cameron (Author) / Cotton, Cassandra (Thesis director) / Taliaferro, Karen (Committee member) / Barrett, The Honors College (Contributor) / Morrison School of Agribusiness (Contributor) / School of Civic & Economic Thought and Leadership (Contributor)
Created2023-05
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Human Immunodeficiency Virus (HIV) remains a persistent problem around the world, even though antiretroviral therapy has shown to be effective in reducing viral load and limiting transmission of the virus. Due to HIV’s infectious nature, visibility, the populations at risk, and its connections to race, class, and sexuality, it is

Human Immunodeficiency Virus (HIV) remains a persistent problem around the world, even though antiretroviral therapy has shown to be effective in reducing viral load and limiting transmission of the virus. Due to HIV’s infectious nature, visibility, the populations at risk, and its connections to race, class, and sexuality, it is more stigmatized than any other illness. HIV stigma has been associated with increased depression, social isolation, and poor psychological adjustment. HIV stigma can influence disclosure and care-seeking behavior. Internet-based interventions have shown to be effective in increasing knowledge on STIs and HIV, however, researchers have tested strategies that include educating participants on HIV to reduce stigma and have found that informational approaches alone are not effective. There is evidence that emotional intelligence and empathy are associated with prosocial behavior and influence attitudes towards stigmatized groups. Thus, this thesis aims to test an online intervention using an informational video from the Center for Disease Control and Prevention (CDC) in combination with an empathy-generating component to reduce stigma. It was hypothesized that the online intervention would increase HIV knowledge scores (H1), but stigma will only be reduced in the group introduced to the empathy-inducing component (H2) and those with high emotional intelligence would show the greatest reduction in stigmatizing attitudes (H3). Results did not support these hypotheses, suggesting that the CDC’s video does not significantly increase HIV knowledge in the general public. Further, the video intended to generate empathy and reduce stigma was also ineffective. These findings stress the need for further research and questions the effectiveness of empathy-generating interventions (e.g., FACES OF HIV, HIV Justice Network) to increase knowledge and reduce stigma. Future researchers should test the effectiveness of personalized interventions to reduce HIV-related stigma.
ContributorsEl-krab, Renee (Author) / Vargas, Perla (Thesis advisor) / Roberts, Nicole (Committee member) / Chen, Angela (Committee member) / Arizona State University (Publisher)
Created2020
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HIV &AIDS is a global epidemic that has affected the lives of millions of people across the world. According to the World Health Organization (WHO), 37.7 million people were living with HIV in 2020. Sub-Saharan Africa has been particularly affected by the epidemic, specifically, the Southern and Eastern Africa region

HIV &AIDS is a global epidemic that has affected the lives of millions of people across the world. According to the World Health Organization (WHO), 37.7 million people were living with HIV in 2020. Sub-Saharan Africa has been particularly affected by the epidemic, specifically, the Southern and Eastern Africa region which accounts for the highest number of new HIV infections, the highest number of people living with HIV, and the highest number of AIDS-related deaths. Botswana, Eswatini and South Africa are countries located in Southern Africa and have been greatly affected by the HIV & AIDS epidemic as Botswana had the highest HIV prevalence from the late 90s to the early 2000s while Eswatini currently has the HIV highest prevalence rate, and South Africa currently has the highest number of people living with HIV in the world. This paper examines the HIV & AIDS health policies adopted by these three countries in their responses to the HIV & AIDS epidemic.

ContributorsOlatotse, Mpho (Author) / Ross, Heather (Thesis director) / Jehn, Megan (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2021-12
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In 2018, He Jiankui uploaded a series of videos to a YouTube channel titled “The He Lab” that detailed one of the first instances of a successful human birth after genome editing had been performed on an embryo using CRISPR-cas9. CRISPR-cas9 is a genome editing tool derived from bacteria that

In 2018, He Jiankui uploaded a series of videos to a YouTube channel titled “The He Lab” that detailed one of the first instances of a successful human birth after genome editing had been performed on an embryo using CRISPR-cas9. CRISPR-cas9 is a genome editing tool derived from bacteria that can be used to cut out and replace specific sequences of DNA. He genetically modified embryos at his lab in Shenzhen, China, to make them immune to contracting HIV through indirect perinatal transmission from their father, who was infected with the virus. HIV is a virus that attacks the immune cells of its host and weakens their ability to fight off diseases. At the time of He’s experiment, various treatments already existed at that could prevent the fetuses from contracting HIV without the need for gene surgery. Nonetheless, He’s experiment led to one of the first successful births of fetuses resulting from genetically modified embryos. He kept his experiment secret until he uploaded the videos announcing the birth of the fetuses, born as two twin girls. The experiment discussed in the videos was successful, but many scientists criticized the experiment due to ethical concerns with the way He conducted it.

Created2021-07-31