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With a growing number of adults with autism spectrum disorder (ASD), more and more research has been conducted on majority male cohorts with ASD from young, adolescence, and some older age. Currently, males make up the majority of individuals diagnosed with ASD, however, recent research states that the gender ga

With a growing number of adults with autism spectrum disorder (ASD), more and more research has been conducted on majority male cohorts with ASD from young, adolescence, and some older age. Currently, males make up the majority of individuals diagnosed with ASD, however, recent research states that the gender gap is closing due to more advanced screening and a better understanding of how females with ASD present their symptoms. Little research has been published on the neurocognitive differences that exist between older adults with ASD compared to neurotypical (NT) counterparts, and nothing has specifically addressed older women with ASD. This study utilized neuroimaging and neuropsychological tests to examine differences between diagnosis and sex of four distinct groups: older men with ASD, older women with ASD, older NT men, and older NT women. In each group, hippocampal size (via FreeSurfer) was analyzed for differences as well as correlations with neuropsychological tests. Participants (ASD Female, n = 12; NT Female, n = 14; ASD Male, n = 30; NT Male = 22), were similar according to age, IQ, and education. The results of the study indicated that the ASD Group as a whole performed worse on executive functioning tasks (Wisconsin Card Sorting Test, Trails Making Test) and memory-related tasks (Rey Auditory Verbal Learning Test, Weschler Memory Scale: Visual Reproduction) compared to the NT Group. Interactions of sex by diagnosis approached significance only within the WCST non-perseverative errors, with the women with ASD performing worse than NT women, but no group differences between men. Effect sizes between the female groups (ASD female vs. NT female) showed more than double that of the male groups (ASD male vs. NT male) for all WCST and AVLT measures. Participants with ASD had significantly smaller right hippocampal volumes than NT participants. In addition, all older women showed larger hippocampal volumes when corrected for total intracranial volume (TIV) compared to all older men. Overall, NT Females had significant correlations across all neuropsychological tests and their hippocampal volumes whereas no other group had significant correlations. These results suggest a tighter coupling between hippocampal size and cognition in NT Females than NT Males and both sexes with ASD. This study promotes further understanding of the neuropsychological differences between older men and women, both with and without ASD. Further research is needed on a larger sample of older women with and without ASD.
ContributorsWebb, Christen Len (Author) / Braden, B. Blair (Thesis advisor) / Azuma, Tamiko (Committee member) / Dixon, Maria (Committee member) / Arizona State University (Publisher)
Created2019
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Description
This pilot study evaluated whether Story Champs and Puente de Cuentos helped bilingual preschoolers increase their usage of emotional terms and ability to tell stories. Participants in this study included 10 Spanish-English bilingual preschoolers. Intervention was conducted in 9 sessions over 3 days using the Test of Narrative Retell to

This pilot study evaluated whether Story Champs and Puente de Cuentos helped bilingual preschoolers increase their usage of emotional terms and ability to tell stories. Participants in this study included 10 Spanish-English bilingual preschoolers. Intervention was conducted in 9 sessions over 3 days using the Test of Narrative Retell to measure results. Results did not find significant gains in either emotional term usage or ability to tell stories, but the results were promising as a pilot study.
ContributorsSato, Leslie Mariko (Author) / Restrepo, Maria (Thesis director) / Dixon, Maria (Committee member) / Department of Speech and Hearing Science (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description

The present study investigated the communicative characteristics of challenging behavior documented in children with Autism Spectrum Disorder (ASD), and how those behaviors changed as receptive and expressive language skills changed. Several years of the individual education plans (IEPs), behavior plans, and test scores of three male students from a small

The present study investigated the communicative characteristics of challenging behavior documented in children with Autism Spectrum Disorder (ASD), and how those behaviors changed as receptive and expressive language skills changed. Several years of the individual education plans (IEPs), behavior plans, and test scores of three male students from a small non- public school (NPS) were reviewed for this study. Challenging behaviors that served a communicative function showed some signs of diminishing as functional communication increased. While functional communication did show signs of increasing with the acquisition of expressive and receptive language the participants differed in their dependence on prompting to use functional communication in lieu of challenging behavior. Additionally, some of the challenging behaviors were rooted in a difficulty with self-regulation and stimming behavior and didn't appear to serve a communicative function. Given the significant impact challenging behaviors have on the quality life of the children with ASD and their families, more research is needed to better understand the connection between spontaneous and independent functional communication and duration to independent attention to task effects on challenging behavior.

ContributorsPringle, Deborah (Author) / Bruce, Laurel (Thesis director) / Dixon, Maria (Committee member) / Elliott, Alicia (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor)
Created2023-05
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Description
Individuals with autism spectrum disorder (ASD) are known to show impairments in various domains of executive function (EF) such as behavioral flexibility or inhibitory control. Research suggests that EF impairment in adults with ASD may relate to ASD core symptoms, restrictive behaviors and social communication deficits. Mindfulness-based stress

Individuals with autism spectrum disorder (ASD) are known to show impairments in various domains of executive function (EF) such as behavioral flexibility or inhibitory control. Research suggests that EF impairment in adults with ASD may relate to ASD core symptoms, restrictive behaviors and social communication deficits. Mindfulness-based stress reduction (MBSR) has shown promise for improving EF abilities in neurotypical adults, but research has not explored its efficacy or neural mechanisms in adults with ASD. This pilot study examines the effects of an 8-week MBSR intervention on self-report measures of EF and resting-state functional connectivity in a sample of adults with ASD. Fifty-four participants were assigned either to an MBSR group (n = 29) or a social support group (n = 25). Executive function was measured using the BRIEF-2 before and after the intervention for the twenty-seven participants in the second cohort. MBSR-specific improvements in EF were found for BRIEF measures of initiation, inhibition, and working-memory. Resting-state fMRI data was analyzed using independent component analysis (ICA), and group by time resting-state functional connectivity differences were observed between the cerebellar network and frontal regions including the right frontal pole (rFP), medial frontal cortex (MFC) and left and right superior frontal gyri (SFG). The MBSR group showed increases in functional connectivity between the cerebellum and EF regions which correlated with improvements in BRIEF-2 measures. These findings suggest that MBSR may improve EF domains in adults with ASD, and that increases in functional connectivity between the cerebellum and frontal regions while at rest may be a mechanism for such improvements.
ContributorsGuerithault, Nicolas (Author) / Braden, B. Blair (Thesis advisor) / Rogalsky, Corianne (Committee member) / Dixon, Maria (Committee member) / Arizona State University (Publisher)
Created2021