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The action/adventure game Grad School: HGH is the final, extended version of a BME Prototyping class project in which the goal was to produce a zombie-themed game that teaches biomedical engineering concepts. The gameplay provides fast paced, exciting, and mildly addicting rooms that the player must battle and survive through,

The action/adventure game Grad School: HGH is the final, extended version of a BME Prototyping class project in which the goal was to produce a zombie-themed game that teaches biomedical engineering concepts. The gameplay provides fast paced, exciting, and mildly addicting rooms that the player must battle and survive through, followed by an engineering puzzle that must be solved in order to advance to the next room. The objective of this project was to introduce the core concepts of BME to prospective students, rather than attempt to teach an entire BME curriculum. Based on user testing at various phases in the project, we concluded that the gameplay was engaging enough to keep most users' interest through the educational puzzles, and the potential for expanding this project to reach an even greater audience is vast.
ContributorsNitescu, George (Co-author) / Medawar, Alexandre (Co-author) / Spano, Mark (Thesis director) / LaBelle, Jeffrey (Committee member) / Guiang, Kristoffer (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
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Research concerning increased sensitivity and accurate glucose sensors have been on the forefront of diabetes mellitus. In this study, Electroactive Poly-Amidoamine Polymer (EPOP) was studied to determine if it can be used as a biocompatible electrode, with known redox mediators to determine if it can transfer its own electrons or

Research concerning increased sensitivity and accurate glucose sensors have been on the forefront of diabetes mellitus. In this study, Electroactive Poly-Amidoamine Polymer (EPOP) was studied to determine if it can be used as a biocompatible electrode, with known redox mediators to determine if it can transfer its own electrons or amplify signal, and if signal is amplified when using an Ag/AgCl working electrode. From the results, it was determined that EPOP is neither a redox mediator, since it cannot transfer its own electrons, nor an electron mediator, since it does not amplify measured current at a specific voltage. Rather, it behaves as an electron sink capacitor with inconsistent behavior when Ag/AgCl is used as the working electrode with the redox mediator alone or with the redox mediator using in combination with glucose oxidase (GOx) and glucose. This was validated using AC-Impedance which gave a -3.3999 slope for isolated 0.05 g/mL EPOP in solution and R2 value of 0.992 displaying it had more capacitor-like behavior compared to resistor-like behavior. For this reason, EPOP was infused into a carbon screen-printed electrode by adding it dissolved and undissolved at two levels into carbon ink. The effectiveness of this electrode was tested using a potentiostatic CV. For the 0.1 g/mL EPOP dissolved in carbon ink, the reduction voltage peak (0.18 V) was found to be slightly higher than a GDE (0.14 V); however, the measured current was found to be 1.57 times the amplitude of a GDE. When 0.05 g/mL EPOP in PBS dissolved in graphite ink was used to detect glucose as the working electrode, there was increased signal amplification, and therefore, increased sensitivity to glucose when using EPOP infused electrodes. This offers promising results for disposable glucose sensors.
ContributorsKapadia, Meera Vipul (Author) / LaBelle, Jeffrey (Thesis director) / Islam, Rafiqul (Committee member) / Honikel, Mackenzie (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
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Description
The American Diabetes Association reports that diabetes costs $322 billion annually and affects 29.1 million Americans. The high out-of-pocket cost of managing diabetes can lead to noncompliance causing serious and expensive complications. There is a large market potential for a more cost-effective alternative to the current market standard of screen-printed

The American Diabetes Association reports that diabetes costs $322 billion annually and affects 29.1 million Americans. The high out-of-pocket cost of managing diabetes can lead to noncompliance causing serious and expensive complications. There is a large market potential for a more cost-effective alternative to the current market standard of screen-printed self-monitoring blood glucose (SMBG) strips. Additive manufacturing, specifically 3D printing, is a developing field that is growing in popularity and functionality. 3D printers are now being used in a variety of applications from consumer goods to medical devices. Healthcare delivery will change as the availability of 3D printers expands into patient homes, which will create alternative and more cost-effective methods of monitoring and managing diseases, such as diabetes. 3D printing technology could transform this expensive industry. A 3D printed sensor was designed to have similar dimensions and features to the SMBG strips to comply with current manufacturing standards. To make the sensor electrically active, various conductive filaments were tested and the conductive graphene filament was determined to be the best material for the sensor. Experiments were conducted to determine the optimal print settings for printing this filament onto a mylar substrate, the industry standard. The reagents used include a mixture of a ferricyanide redox mediator and flavin adenine dinucleotide dependent glucose dehydrogenase. With these materials, each sensor only costs $0.40 to print and use. Before testing the 3D printed sensor, a suitable design, voltage range, and redox probe concentration were determined. Experiments demonstrated that this novel 3D printed sensor can accurately correlate current output to glucose concentration. It was verified that the sensor can accurately detect glucose levels from 25 mg/dL to 400 mg/dL, with an R2 correlation value as high as 0.97, which was critical as it covered hypoglycemic to hyperglycemic levels. This demonstrated that a 3D-printed sensor was created that had characteristics that are suitable for clinical use. This will allow diabetics to print their own test strips at home at a much lower cost compared to SMBG strips, which will reduce noncompliance due to the high cost of testing. In the future, this technology could be applied to additional biomarkers to measure and monitor other diseases.
ContributorsAdams, Anngela (Author) / LaBelle, Jeffrey (Thesis advisor) / Pizziconi, Vincent (Committee member) / Abbas, James (Committee member) / Arizona State University (Publisher)
Created2017