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Leo Kanner and the psychobiology of autism

Description
Leo Kanner first described autism in his 1943 article in Nervous Child titled "Autistic Disturbances of Affective Contact". Throughout, he describes the eleven children with autism in exacting detail. In the closing paragraphs, the parents of autistic children are described as emotionally cold. Yet, he concludes that the condition as…

Leo Kanner first described autism in his 1943 article in Nervous Child titled "Autistic Disturbances of Affective Contact". Throughout, he describes the eleven children with autism in exacting detail. In the closing paragraphs, the parents of autistic children are described as emotionally cold. Yet, he concludes that the condition as he described it was innate. Since its publication, his observations about parents have been a source of controversy surrounding the original definition of autism.

Thus far, histories about autism have pointed to descriptions of parents of autistic children with the claim that Kanner abstained from assigning them causal significance. Understanding the theoretical context in which Kanner's practice was embedded is essential to sorting out how he could have held such seemingly contrary views simultaneously.

This thesis illustrates that Kanner held an explicitly descriptive frame of reference toward his eleven child patients, their parents, and autism. Adolf Meyer, his mentor at Johns Hopkins, trained him to make detailed life-charts under a clinical framework called psychobiology. By understanding that Kanner was a psychobiologist by training, I revisit the original definition of autism as a category of mental disorder and restate its terms. This history illuminates the theoretical context of autism's discovery and has important implications for the first definition of autism amidst shifting theories of childhood mental disorders and the place of the natural sciences in defining them.
ContributorsCohmer, Sean (Author) / Hurlbut, James B (Thesis advisor) / Maienschein, Jane (Committee member) / Laubichler, Manfred (Committee member) / Arizona State University (Publisher)
Created2014
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Purple in the morning, blue in the afternoon, orange in the evening: a genealogical analysis of depressive disorders in the American Psychiatric Association's diagnostic and statistical manual, fifth edition

Description
The American Psychiatric Association's Diagnostic and Statistical Manual, the official guidebook to psychiatric diagnosis in America, currently exempts the recently bereaved from being diagnosed with depression unless their experiences are marked by feelings of extreme worthlessness, significant functional impairment, psychotic symptoms, psychomotor retardation, or suicidal ideation. Ordinary symptoms of depression,…

The American Psychiatric Association's Diagnostic and Statistical Manual, the official guidebook to psychiatric diagnosis in America, currently exempts the recently bereaved from being diagnosed with depression unless their experiences are marked by feelings of extreme worthlessness, significant functional impairment, psychotic symptoms, psychomotor retardation, or suicidal ideation. Ordinary symptoms of depression, such as sleeplessness or loss of appetite, are considered healthy, functional emotional responses to the loss of a loved one. The bereavement exemption is slated for removal in the upcoming fifth edition of the Diagnostic and Statistical Manual, functionally redefining the emotional distress of bereavement as a psychiatric disorder. This study employs genealogical analysis to expose the multiplicity of forces that shape modern psychiatry and the ways that the redefinition of depression functions strategically in the social negotiation of truth and power. Under the guise of etiological and prescriptive neutrality, the redefinition of depression promotes a deeply biological model of psychiatric disorder, a medicalized understanding of human emotion, and a pharmacological approach to the treatment of emotional distress. Through genealogical analysis, this project seeks to enable informed, meaningful ethico-political responses to these developments.
ContributorsMeeth, John (Author) / Edson, Belle (Thesis advisor) / Palazzolo, Kellie (Thesis advisor) / Quinlivan, Raena (Committee member) / Arizona State University (Publisher)
Created2011
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Adverse Side Effects of Pharmacological Agents for Pediatric Anxiety Disorders: A Critical Review

Description

Pediatric anxiety disorders are highly prevalent and while pharmacological intervention seems to be an effective treatment, the validity of reported adverse side effects remains unclear. <br/><br/>Objective: To analyze the nature of evidence regarding adverse side effects in the pharmacological treatment of pediatric anxiety disorders. <br/><br/>Approach: A search using Google Scholar,…

Pediatric anxiety disorders are highly prevalent and while pharmacological intervention seems to be an effective treatment, the validity of reported adverse side effects remains unclear. <br/><br/>Objective: To analyze the nature of evidence regarding adverse side effects in the pharmacological treatment of pediatric anxiety disorders. <br/><br/>Approach: A search using Google Scholar, PubMed, and PsychInfo was conducted for meta-analyses of pharmacological treatment of pediatric anxiety disorders as well as randomized controlled trials. The focus was on adverse events.<br/><br/>Results and Conclusion: Reportings of a limited number of adverse events were found among resources available to clinician and patient informed sources to inform pharmacological treatment of pediatric anxiety disorders. Only a small fraction of adverse side effects were found in the research literature. This finding raises concerns about making informed decisions to treat pediatric anxiety disorders with pharmacotherapy.
ContributorsMartin, Mark (Co-author) / Reyes, Trevin (Co-author) / Whooley, Max (Co-author) / Pina, Armando (Thesis director) / Benoit, Renee (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05