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The tendency for psychopathology to aggregate within families is well-documented, though little is known regarding the level of specificity at which familial transmission of symptomology occurs. The current study first tested competing higher-order structures of psychopathology in adolescence, indexing general and more specific latent factors. Second, parent-offspring transmission was tested

The tendency for psychopathology to aggregate within families is well-documented, though little is known regarding the level of specificity at which familial transmission of symptomology occurs. The current study first tested competing higher-order structures of psychopathology in adolescence, indexing general and more specific latent factors. Second, parent-offspring transmission was tested for broadband domain specificity versus transmission of a general liability for psychopathology. Lastly, genetic and environmental mechanisms underlying the familial aggregation of psychopathology were examined using nuclear twin-family models. The sample was comprised of five hundred adolescent twin pairs (mean age 13.24 years) and their parents drawn from the Wisconsin Twin Project. Twins and parents completed independent diagnostic interviews. For aim 1, correlated factors, bifactor, and general-factor models were tested using adolescent symptom count data. For aim 2, structural equation modeling was used to determine whether broadband domain-specific transmission effects were necessary to capture parent-offspring resemblance in psychopathology above and beyond a general transmission effect indexed by the latent correlation between a parental internalizing factor and offspring P-factor. For aim 3, general factor models were fitted in both generations, and factor scores were subsequently extracted and used in nuclear twin-family model testing. Results indicated that the bifactor model exhibited the best fit to the adolescent data. Familial aggregation of psychopathology was sufficiently accounted for by the transmission of a general liability. Lastly, the best fitting reduced nuclear twin-family model indicated that additive genetic, sibling-specific shared environmental, and nonshared environmental influences contributed to general psychopathology. Parent-offspring transmission was accounted for by shared genetics only, whereas co-twin aggregation was additionally explained by sibling-specific shared environmental factors. Results provide novel insight into the specificity and etiology of the familial aggregation of psychopathology.
ContributorsOro, Veronica (Author) / Lemery-Chalfant, Kathryn (Thesis advisor) / Chassin, Laurie (Committee member) / Doane, Leah D (Committee member) / Arizona State University (Publisher)
Created2019
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Description

Pediatric anxiety disorders are highly prevalent and while pharmacological intervention seems to be an effective treatment, the validity of reported adverse side effects remains unclear. <br/><br/>Objective: To analyze the nature of evidence regarding adverse side effects in the pharmacological treatment of pediatric anxiety disorders. <br/><br/>Approach: A search using Google Scholar,

Pediatric anxiety disorders are highly prevalent and while pharmacological intervention seems to be an effective treatment, the validity of reported adverse side effects remains unclear. <br/><br/>Objective: To analyze the nature of evidence regarding adverse side effects in the pharmacological treatment of pediatric anxiety disorders. <br/><br/>Approach: A search using Google Scholar, PubMed, and PsychInfo was conducted for meta-analyses of pharmacological treatment of pediatric anxiety disorders as well as randomized controlled trials. The focus was on adverse events.<br/><br/>Results and Conclusion: Reportings of a limited number of adverse events were found among resources available to clinician and patient informed sources to inform pharmacological treatment of pediatric anxiety disorders. Only a small fraction of adverse side effects were found in the research literature. This finding raises concerns about making informed decisions to treat pediatric anxiety disorders with pharmacotherapy.

ContributorsMartin, Mark (Co-author) / Reyes, Trevin (Co-author) / Whooley, Max (Co-author) / Pina, Armando (Thesis director) / Benoit, Renee (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The thesis project merges interdisciplinary research to develop a self-directed creative intervention for immigrant youth, allowing them to make sense of their social and cultural identities. It takes research on self-awareness, multicultural identification, perceived belonging, and bibliotherapy to create a guided journal titled "Unearth," filled with art and writing prompts

The thesis project merges interdisciplinary research to develop a self-directed creative intervention for immigrant youth, allowing them to make sense of their social and cultural identities. It takes research on self-awareness, multicultural identification, perceived belonging, and bibliotherapy to create a guided journal titled "Unearth," filled with art and writing prompts that are age-appropriate for adolescents and that serve as avenues for self-exploration. The project ultimately engages a focus group discussion to understand the usability and accessibility of the intervention.

ContributorsNawrocki, Andrea Elizabeth (Co-author) / Dizon, Arni (Co-author) / Pina, Armando (Thesis director) / Benoit, Renee (Committee member) / Causadias, Jose (Committee member) / Historical, Philosophical & Religious Studies (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

Suicide is a significant public health problem, with incidence rates and lethality continuing to increase yearly. Given the large human and financial cost of suicide worldwide alongside the lack of progress in suicide prediction, more research is needed to inform suicide prevention and intervention efforts. This study approaches suicide from

Suicide is a significant public health problem, with incidence rates and lethality continuing to increase yearly. Given the large human and financial cost of suicide worldwide alongside the lack of progress in suicide prediction, more research is needed to inform suicide prevention and intervention efforts. This study approaches suicide from the lens of suicide note-leaving behavior, which can provide important information on predictors of suicide. Specifically, this study adds to the existing literature on note-leaving by examining history of suicidality, mental health problems, and their interaction in predicting suicide note-leaving, in addition to demographic predictors of note-leaving examined in previous research using data from the National Violent Death Reporting System (NVDRS, n = 98,515). We fit a logistic regression model predicting leaving a suicide note or not, the results of which indicated that those with mental health problems or a history of suicidality were more likely to leave a suicide note than those without such histories, and those with both mental health problems and a history of suicidality were most likely to leave a suicide note. These findings reinforce the need to tailor suicide prevention efforts toward identifying and targeting higher risk populations.

ContributorsCarnesi, Gregory (Author) / O'Rourke, Holly (Thesis director) / Brewer, Gene (Committee member) / Corbin, William (Committee member) / Chassin, Laurie (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2022-05
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ContributorsCarnesi, Gregory (Author) / O'Rourke, Holly (Thesis director) / Brewer, Gene (Committee member) / Corbin, William (Committee member) / Chassin, Laurie (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2022-05
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ContributorsCarnesi, Gregory (Author) / O'Rourke, Holly (Thesis director) / Brewer, Gene (Committee member) / Corbin, William (Committee member) / Chassin, Laurie (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2022-05
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Description
This study aimed to advance understanding of the relation between social media and adolescent alcohol use while accounting for offline peer alcohol use, exploring offline peer alcohol use separately as a covariate and as a moderator, with an additional exploratory analysis of the relation between social media and alcohol use

This study aimed to advance understanding of the relation between social media and adolescent alcohol use while accounting for offline peer alcohol use, exploring offline peer alcohol use separately as a covariate and as a moderator, with an additional exploratory analysis of the relation between social media and alcohol use without offline peer alcohol use in the model. A total of 868 students (55% female) in grade 7 (n = 468) and grade 8 (n = 400) at wave 1, self-reported on alcohol use, binge drinking, and social media use as well as nominated friends from their school and grade. Data from nominated peers who also completed the questionnaires were used for peer-report of alcohol use. Data were collected annually from students at grades 8, 9, 10, and 11 were used in analyses. Final structural models consisted of a cross-lagged panel design with saved factor scores for social media and peer alcohol use predicting a categorical alcohol use variable or a binary binge drinking variable. With offline peer alcohol use as a covariate in the model, social media did not prospectively relate to subsequent grade alcohol use or binge drinking. However, without offline peer alcohol use, the path from social media use to subsequent grade alcohol use was significant but not the path to binge drinking. Offline peer alcohol use did not significantly moderate the relation between social media and subsequent grade alcohol use or binge drinking.
ContributorsCurlee, Alexandria Stephanie (Author) / Corbin, William R. (Thesis advisor) / Chassin, Laurie (Committee member) / Doane, Leah D (Committee member) / Grimm, Kevin J. (Committee member) / Arizona State University (Publisher)
Created2020