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Is it possible to treat the mouth as a natural environment, and determine new methods to keep the microbiome in check? The need for biodiversity in health may suggest that every species carries out a specific function that is required to maintain equilibrium and homeostasis within the oral cavity. Furthermore,

Is it possible to treat the mouth as a natural environment, and determine new methods to keep the microbiome in check? The need for biodiversity in health may suggest that every species carries out a specific function that is required to maintain equilibrium and homeostasis within the oral cavity. Furthermore, the relationship between the microbiome and its host is mutually beneficial because the host is providing microbes with an environment in which they can flourish and, in turn, keep their host healthy. Reviewing examples of larger scale environmental shifts could provide a window by which scientists can make hypotheses. Certain medications and healthcare treatments have been proven to cause xerostomia. This disorder is characterized by a dry mouth, and known to be associated with a change in the composition, and reduction, of saliva. Two case studies performed by Bardow et al, and Leal et al, tested and studied the relationships of certain medications and confirmed their side effects on the salivary glands [2,3]. Their results confirmed a relationship between specific medicines, and the correlating complaints of xerostomia. In addition, Vissink et al conducted case studies that helped to further identify how radiotherapy causes hyposalivation of the salivary glands [4]. Specifically patients that have been diagnosed with oral cancer, and are treated by radiotherapy, have been diagnosed with xerostomia. As stated prior, studies have shown that patients having an ecologically balanced and diverse microbiome tend to have healthier mouths. The oral cavity is like any biome, consisting of commensalism within itself and mutualism with its host. Due to the decreased salivary output, caused by xerostomia, increased parasitic bacteria build up within the oral cavity thus causing dental disease. Every human body contains a personalized microbiome that is essential to maintaining health but capable of eliciting disease. The Human Oral Microbiomics Database (HOMD) is a set of reference 16S rRNA gene sequences. These are then used to define individual human oral taxa. By conducting metagenomic experiments at the molecular and cellular level, scientists can identify and label micro species that inhabit the mouth during parasitic outbreaks or a shifting of the microbiome. Because the HOMD is incomplete, so is our ability to cure, or prevent, oral disease. The purpose of the thesis is to research what is known about xerostomia and its effects on the complex microbiome of the oral cavity. It is important that researchers determine whether this particular perspective is worth considering. In addition, the goal is to create novel experiments for treatment and prevention of dental diseases.
ContributorsHalcomb, Michael Jordan (Author) / Chen, Qiang (Thesis director) / Steele, Kelly (Committee member) / Barrett, The Honors College (Contributor) / College of Letters and Sciences (Contributor)
Created2015-05
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This study addresses the question: is it possible for consumers to make informed decisions regarding their privacy, while using smartphones, in the face of the complex web of actors, incentives, and conveniences afforded by the technology? To address this question, the Social Construction of Technology (SCOT) model is used to

This study addresses the question: is it possible for consumers to make informed decisions regarding their privacy, while using smartphones, in the face of the complex web of actors, incentives, and conveniences afforded by the technology? To address this question, the Social Construction of Technology (SCOT) model is used to analyze common situations consumers find themselves engaged in. Using the SCOT model, relevant actors are identified; their interpretations of various technologies are expressed; relative power is discussed; and possible directions for closure are examined. This analysis takes place by looking at three specific themes within privacy disputes in general: anonymity, confidentiality, and surveillance. These themes are compared and contrasted in regards to their impact on perception of privacy and implications for closure. Arguments are supported through evidence drawn from scholarship on the topic as well as industry and news media. Conclusions are supported through the framework of anticipatory governance.
ContributorsKula, Shane (Author) / Hackett, Ed (Thesis director) / Sarewitz, Daniel (Committee member) / Wetmore, Jamey (Committee member) / Barrett, The Honors College (Contributor) / College of Letters and Sciences (Contributor) / School of Sustainability (Contributor) / School of Life Sciences (Contributor)
Created2015-05