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- All Subjects: Technology
- Creators: Barrett, The Honors College
Description
Genistein, a compound found in soy that functions as a phytoestrogen, has been found to play a role in the body’s inflammatory response. By suppressing the expression of inflammatory genes and inhibiting tumor cell growth, genistein is thought to have both anti-inflammatory and cancer fighting properties. This study seeks to demonstrate genistein’s potential to mitigate the negative consequences of consuming a high fat diet specifically as it relates to increased inflammation and changes in the gut microbiome. Using an animal model, the study tested whether supplementing the mice’s diet with soy derived genistein would affect their serum IL-6 levels and the way in which their gut microbiomes responded to their high fat consumption. It was presumed that genistein supplementation would result in a less significant shift from the biomarkers tested in the control group and reduce the impact of the high fat diet. It was also hypothesized that consumption of the high fat diet would raise IL-6 levels and increase the presence of harmful bacteria in the test subjects.
ContributorsPettit, Gabrielle Sofia (Author) / Whisner, Dr. Corrie (Thesis director) / Al-Nakkash, Dr. Layla (Committee member) / Ortega Santos, Carmen (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Accessible STEAM (Science, Technology, Engineering, Art, and Mathematics) education is imperative in creating the future innovators of the world. This business proposal is for a K-8 STEAM Museum to be built in the Novus Innovation Corridor on Arizona State University (ASU)’s Tempe campus. The museum will host dynamic spaces that are constantly growing and evolving as exhibits are built by interdisciplinary capstone student groups- creating an internal capstone project pipeline. The intention of the museum is to create an interactive environment that fosters curiosity and creativity while acting as supplemental learning material to Arizona K-8 curriculum. The space intends to serve the greater Phoenix area community and will cater to underrepresented audiences through the development of accessible education rooted in equality and inclusivity.
ContributorsPeters, Abigail J (Author) / McCarville, Daniel R. (Thesis director) / Juarez, Joseph (Committee member) / Industrial, Systems & Operations Engineering Prgm (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
In the world we live in today, nothing is impossible. Due to the advancements of technology, humans around the globe are able to hold computers that fit within the size of their pocket. These computers can do marvelous things, however run off batteries. These batteries need to be charged and up until a little while ago there was only one option available: wired chargers; however, because of the advancement of technology society has created a way to transfer power via magnetic fields. Now this concept has been around for a long time since the days of Nikola Tesla but just recently society has been able to apply his discoveries to charging these computers in our pockets. Unfortunately, the current models of these chargers come with a drawback as they are less efficient than wired chargers. However, this is the question our group has set out to answer. Is there any way possible to improve the efficiency of these wireless chargers so they are equal or even more efficient than wired chargers. This paper explores how to improve the efficiency in wireless chargers. Through research, simulations and testing the group has discovered areas that efficiency can be improved as well as makes recommendations to change the current wireless chargers on the market today. This paper also explores future applications of wireless chargers that can not only make life much easier but could also save lives in some cases. These applications can have many effects on hospitality, the medical field, as well as the supply chain and logistics of America.
ContributorsMcCulley, Matthew Alan (Co-author) / Cole, Kennedy (Co-author) / Chickamenahalli, Shamala (Thesis director) / Chakrabarti, Chaitali (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Over the course of his four years of course, Matt Stockmal has told multiple historical stories for multiple different groups in multiple different mediums. As a Digital Culture major, these storytelling mediums were all infused with creative technology. As Matt comes to the close of his college career, he wanted to take the time to review his work, reflect on the merits of the medium used with regards to its ability to instill visceral impact, and write a series of tutorials using what was learned in the process of experimentation in historical storytelling.
The paper is meant to serve as a base of reference material for future, real world, project proposals to historical organizations. A mock proposal to the Fullersburg Historic Foundation, proposing the digital mediums and methods discussed, is included at the end of the paper.
In concluding thoughts, Matt I appears to have the depth and breadth of skills needed to make impactful media. And the mediums of media have been as diverse as the subjects they cover. But upon reviewing his own review, it took someone else smarter had to tell me that though there is diversity abound in his portfolio, there is a single baseline: Keeping history alive. Every one of these mediums can be used to infuse a sense of digital energy, simulated life, back into historical artifacts and documentation. The historical characters return to live when a medium brings back the motion, the energy, of the thing it is showing. If the medium infuses this life back into the story. The results are nothing short of magic.
The paper is meant to serve as a base of reference material for future, real world, project proposals to historical organizations. A mock proposal to the Fullersburg Historic Foundation, proposing the digital mediums and methods discussed, is included at the end of the paper.
In concluding thoughts, Matt I appears to have the depth and breadth of skills needed to make impactful media. And the mediums of media have been as diverse as the subjects they cover. But upon reviewing his own review, it took someone else smarter had to tell me that though there is diversity abound in his portfolio, there is a single baseline: Keeping history alive. Every one of these mediums can be used to infuse a sense of digital energy, simulated life, back into historical artifacts and documentation. The historical characters return to live when a medium brings back the motion, the energy, of the thing it is showing. If the medium infuses this life back into the story. The results are nothing short of magic.
ContributorsStockmal, Matthew Eric (Author) / Pinholster, Jacob (Thesis director) / Foushee, Danielle (Committee member) / Arts, Media and Engineering Sch T (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The retinoid-X receptor (RXR) can form heterodimers with both the retinoic-acid
receptor (RAR) and vitamin D receptor (VDR). The RXR/RAR dimer is activated by ligand all
trans retinoic acid (ATRA), which culminates in gut-specific effector T cell migration. Similarly,
the VDR/RXR dimer binds 1,25(OH)2D3 to cause skin-specific effector T cell migration.
Targeted migration is a potent addition to current vaccines, as it would induce activated T cell
trafficking to appropriate areas of the immune system and ensure optimal stimulation (40).
ATRA, while in use clinically, is limited by toxicity and chemical instability. Rexinoids
are stable, synthetically developed ligands specific for the RXR. We have previously shown that
select rexinoids can enhance upregulation of gut tropic CCR9 receptors on effector T cells.
However, it is important to establish whether these cells can actually migrate, to show the
potential of rexinoids as vaccine adjuvants that can cause gut specific T cell migration.
Additionally, since the RXR is a major contributor to VDR-mediated transcription and
epidermotropism (15), it is worth investigating whether these compounds can also function as
adjuvants that promote migration by increasing expression of skin tropic CCR10 receptors on T
cells.
Prior experiments have demonstrated that select rexinoids can induce gut tropic migration
of CD8+ T cells in an in vitro assay and are comparable in effectiveness to ATRA (7). The effect
of rexinoids on CD4+ T cells is unknown however, so the aim of this project was to determine if
rexinoids can cause gut tropic migration in CD4+ T cells to a similar extent. A secondary aim
was to investigate whether varying concentrations in 1,25-Dihydroxyvitamin D3 can be linked to
increasing CCR10 upregulation on Jurkat CD4+ T cells, with the future aim to combine 1,25
Dihydroxyvitamin D3 with rexinoids.
These hypotheses were tested using murine splenocytes for the migration experiment, and
human Jurkat CD4+ T cells for the vitamin D experiment. Migration was assessed using a
Transwell chemotaxis assay. Our findings support the potential of rexinoids as compounds
capable of causing gut-tropic migration in murine CD4+ T cells in vitro, like ATRA. We did not
observe conclusive evidence that vitamin D3 causes upregulated CCR10 expression, but this
experiment must be repeated with a human primary T cell line.
receptor (RAR) and vitamin D receptor (VDR). The RXR/RAR dimer is activated by ligand all
trans retinoic acid (ATRA), which culminates in gut-specific effector T cell migration. Similarly,
the VDR/RXR dimer binds 1,25(OH)2D3 to cause skin-specific effector T cell migration.
Targeted migration is a potent addition to current vaccines, as it would induce activated T cell
trafficking to appropriate areas of the immune system and ensure optimal stimulation (40).
ATRA, while in use clinically, is limited by toxicity and chemical instability. Rexinoids
are stable, synthetically developed ligands specific for the RXR. We have previously shown that
select rexinoids can enhance upregulation of gut tropic CCR9 receptors on effector T cells.
However, it is important to establish whether these cells can actually migrate, to show the
potential of rexinoids as vaccine adjuvants that can cause gut specific T cell migration.
Additionally, since the RXR is a major contributor to VDR-mediated transcription and
epidermotropism (15), it is worth investigating whether these compounds can also function as
adjuvants that promote migration by increasing expression of skin tropic CCR10 receptors on T
cells.
Prior experiments have demonstrated that select rexinoids can induce gut tropic migration
of CD8+ T cells in an in vitro assay and are comparable in effectiveness to ATRA (7). The effect
of rexinoids on CD4+ T cells is unknown however, so the aim of this project was to determine if
rexinoids can cause gut tropic migration in CD4+ T cells to a similar extent. A secondary aim
was to investigate whether varying concentrations in 1,25-Dihydroxyvitamin D3 can be linked to
increasing CCR10 upregulation on Jurkat CD4+ T cells, with the future aim to combine 1,25
Dihydroxyvitamin D3 with rexinoids.
These hypotheses were tested using murine splenocytes for the migration experiment, and
human Jurkat CD4+ T cells for the vitamin D experiment. Migration was assessed using a
Transwell chemotaxis assay. Our findings support the potential of rexinoids as compounds
capable of causing gut-tropic migration in murine CD4+ T cells in vitro, like ATRA. We did not
observe conclusive evidence that vitamin D3 causes upregulated CCR10 expression, but this
experiment must be repeated with a human primary T cell line.
ContributorsDebray, Hannah Zara (Co-author) / Debray, Hannah (Co-author) / Blattman, Joseph (Thesis director) / Jurutka, Peter (Committee member) / Manhas, Kavita (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Thousands of human lives are lost every day due to chronic diseases, some more preventable than others. For years, the gold standard for diagnosing and monitoring these diseases has been through traditional methods such as individualized doctor-patient clinical evaluations, usually involving laboratory tests. These methods, though effective, can be costly, time-consuming, and fail to encompass an overarching perspective of the health profile of the larger population. Wastewater-based epidemiology (WBE) has successfully been employed for decades as a population-level data source informing on the consumption of licit and illicit substance use. It also is showing promise for its use as a community-wide diagnostic tool for broader public health measurements. This literature review constitutes a theoretical evaluation of the potential use of WBE for monitoring the top two deadly diseases in the United States; cardiovascular disease (CVD) and cancer. Literature-reported metabolites indicative of these diseases were evaluated to determine if they were capable of being identified and monitored in wastewater. Potential analytes include cardiac-specific troponin, α-fenotroin, and inositol. Results obtained within suggest WBE could be used as a viable and economical tool to track and monitor the top deadly diseases in human populations. This methodology could be implemented in tandem with current practices in order to provide a more holistic understanding of prevalence and risk for CVD and cancer.
ContributorsAmin, Vivek (Author) / Halden, Rolf (Thesis director) / Niebuhr, Robert (Committee member) / Bowes, Devin (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
As of March 2020, there were over 112,400 patients actively waiting on the United States national organ transplant waitlist with only about 3,300 donors1. Although transplantation is an effective treatment for end-stage organ failure, the access to a procedure will vary depending on national regulations, cost of health care, extensive screening processes, and the availability of organs2. Organ shortage is a worldwide problem, and the growing insufficiency has resulted patients becoming too for ill or dying while waiting3. Due to the varying wait times and costs of procedures, some patients have begun to outsource their own transplantation through international transactions, also known as transplant tourism2. The 2004 World Health Assembly resolution recognized these trades as a significant health policy issue, while also acknowledging the inability of national health care systems to meet the needs of patients4. To address this issue, a proposal will be made such that all live kidney and liver donors will be compensated $22,500 and $12,150 respectively through a cost-neutral scheme based on annual healthcare expenditures per organ that would be eliminated by a transplant. With this proposal, it is suggested that the organ transplant waitlist would not only be significantly reduced, but potentially eliminated, and the crisis of organ shortage would be defeated.
ContributorsMartin, Starla (Author) / Kingsbury, Jeffrey (Thesis director) / Edmonds, Hallie (Committee member) / School of Molecular Sciences (Contributor) / School of Human Evolution & Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Regenerative medicine is a relatively new area of interest among researchers and physicians alike and has truly come to light within the last twenty years. Its purpose is to “regenerate” cells in our body to return tissue and organs systems to their normal functions by utilizing innate cell mechanisms. Uses have ranged from growing completely new body tissue in labs, to promoting the repair of damaged neurons. More recently, the use of regenerative medicine techniques such as stem cell and platelet rich plasma therapy has seen significant growth throughout high level and professional sports. Beginning in the early 2000s, treatments quickly gained popularity as professional athletes began using them as an alternative to surgery, but this came before any concrete scientific support. This thesis paper will analyze the current statistical data supporting the use of platelet rich plasma and stem cell therapy and associated regulations to describe the connection between regenerative medicine and sports.
ContributorsFritzke, Jack Teodor (Author) / Washo-Krupps, Delon (Thesis director) / Foster, William (Committee member) / Levinson, Simin (Committee member) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The Founders Lab Thesis tasked each team with taking an idea and trying to form a business out of it. In the process, the thesis director would be there to guide each team and provide expertise where needed. The venture that was assigned originally to our team was a posture correcting device, however after numerous attempts to correspond reliably with the developers of this technology, it was decided that the team should move on to a new idea. Therefore, our team took on a venture named Altion Security: an initiative with the main goal being the safekeeping of customers interests. The product that we were tasked with is a bike alarm that simply rings out when it detects someone tampering with it. This product is a solution to the problem of bike thefts. 2 million bikes are stolen each year in North America, which translates roughly to a theft every 30 seconds (Project 529).
There are quite a few readily available products that one can buy if one looks past some of their flaws. A lot of these alarms either require a user to carry an extra communication device, or they are too big or expensive. The proposed solution merges all desirable features of a bike alarm into one module. In light of this, surveys were conducted to ascertain what these qualities would need to be. The top considerations for purchasing this alarm were how costly it would be, the false detection rate, and also the battery life. Additionally, the features that were most requested was the inclusion of a GPS and a camera. In order to incorporate these features, a three year plan was formulated which would culminate into a bike network in which each bike could communicate with other bikes. This would allow for an IOT network to be established, thus far exceeding expectations. The price point for this alarm is USD $10.00-15.00 and can come in a variety of colors. Additionally, this concept can be applied to many different scenarios, from protecting boats/jet skis and other aquatic vehicles, to houses as well. Furthermore, one could miniaturize this technology to be used in jewelry or accessories.
There are quite a few readily available products that one can buy if one looks past some of their flaws. A lot of these alarms either require a user to carry an extra communication device, or they are too big or expensive. The proposed solution merges all desirable features of a bike alarm into one module. In light of this, surveys were conducted to ascertain what these qualities would need to be. The top considerations for purchasing this alarm were how costly it would be, the false detection rate, and also the battery life. Additionally, the features that were most requested was the inclusion of a GPS and a camera. In order to incorporate these features, a three year plan was formulated which would culminate into a bike network in which each bike could communicate with other bikes. This would allow for an IOT network to be established, thus far exceeding expectations. The price point for this alarm is USD $10.00-15.00 and can come in a variety of colors. Additionally, this concept can be applied to many different scenarios, from protecting boats/jet skis and other aquatic vehicles, to houses as well. Furthermore, one could miniaturize this technology to be used in jewelry or accessories.
ContributorsOgunmefun, Adeoluwa (Co-author) / Gong, Alan (Co-author) / Parra, Rocio Ivette (Co-author) / Byrne, Jared (Thesis director) / Sebold, Brent (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Attending a university is a stressful transition for many students leaving their respective support systems. Many universities attempt to mitigate this stress by offering numerous campus resources such as, tutoring services, counseling services, and health services. However, research has shown that many of these resources are under utilized by the general student population because of barriers that include student perception, awareness, and access. Being able to understand these barriers that lead to the under utilization of campus resources can assist with creating resources that are more visible, engaging, and attractive to student populations on many campuses. The question being asked is: how to create an engaging health resource that is attractive, visible, and accessible to students?
Based on research analyzed on the barriers between students and campus resources, the optimization of student outreach, and marketing strategies directed towards students, the creation of a student-led campus health resource followed. Analysis of this research showcased that the medium in which students resources were promoted, and the framework of the resource have an impact on students' awareness of the resource, attractiveness of the student resource, and student resource engagement. Based on these analyses and results, the creation of HealthU occurred to provide a visible, engaging, and attractive student resource to the Arizona State University student body.
Based on research analyzed on the barriers between students and campus resources, the optimization of student outreach, and marketing strategies directed towards students, the creation of a student-led campus health resource followed. Analysis of this research showcased that the medium in which students resources were promoted, and the framework of the resource have an impact on students' awareness of the resource, attractiveness of the student resource, and student resource engagement. Based on these analyses and results, the creation of HealthU occurred to provide a visible, engaging, and attractive student resource to the Arizona State University student body.
ContributorsAlcazar, Ivan (Co-author) / Mora, Leslie (Co-author) / Freeman, Javon (Co-author) / Byrne, Jared (Thesis director) / Sebold, Brent (Committee member) / Department of Information Systems (Contributor) / School of Politics and Global Studies (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05