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Description
Anxiety disorder diagnosis is a risk factor for alcohol use disorders (AUDs), but mechanisms of risk are not well understood. Studies show that anxious individuals receive greater negative reinforcement from alcohol when consumed prior to a stressor, but few studies have examined whether anxious individuals receive greater negative (or positive) reinforcement from alcohol in a general drinking context (i.e., no imminent stressor). Previous studies have also failed to examine possible moderating effects of specific drinking contexts (e.g., drinking in a group or alone). Finally, no studies have investigated mediating variables that might explain the relationship between anxiety and reinforcement from alcohol, such as physiological response to alcohol (e.g., cortisol response). Data for this study were drawn from a large alcohol administration study (N = 447) wherein participants were randomized to receive alcohol (target peak BAC: .08 g%) or placebo in one of four contexts: group simulated bar, solitary simulated bar, group sterile laboratory, solitary sterile laboratory. It was hypothesized that anxiety would be associated with positive subjective response (SR) under alcohol (above and beyond placebo), indicating stronger reinforcement from alcohol. It was also hypothesized that social and physical drinking context would moderate this relationship. Finally, it was hypothesized that anxiety would be associated with a blunted cortisol response to alcohol (compared to placebo) and this blunted cortisol response would be associated with stronger positive SR and weaker negative SR. Results showed that anxiety was not associated with positive SR in the full sample, but drinking context did moderate the anxiety/SR relationship in most cases (e.g., anxiety was significantly associated with positive SR (stimulation) under placebo in solitary contexts only). There was no evidence that cortisol response to alcohol mediated the relationship between anxiety and SR. This study provides evidence that anxious drinkers expect stronger positive reinforcement from alcohol in solitary contexts, which has implications for intervention (e.g., modification of existing interventions like expectancy challenge). Null findings regarding cortisol response suggest alcohol’s effect on cortisol response to stress (rather than cortisol response to alcohol consumption) may be more relevant for SR and drinking behavior among anxious individuals.
ContributorsMenary, Kyle Robert (Author) / Corbin, William (Thesis advisor) / Chassin, Laurie (Committee member) / Meier, Madeline (Committee member) / Grimm, Kevin (Committee member) / Arizona State University (Publisher)
Created2018
Description
The need to fully understand the possible consequences of young-adult cannabis use has become increasingly critical as a result of major cannabis policy changes. The purpose of this study was to determine if young-adult users exhibit cognitive deficits on laboratory-based tests and memory and attention deficits in everyday life. Participants were 152 students from a large U.S. university enrolled in introductory psychology courses and the top and bottom 10% of the 12-item Yale University PRIME Screening Test for psychotic-like experiences. Participants were asked about their cannabis use and were given six cognitive tests spanning executive function and memory. To test functional impairment in memory and attention, participants were asked to nominate informants (people who knew them well) and these rated the participants on an attention problems scale of four items and a memory problems scale of three items. Results showed that individuals who used cannabis more frequently were rated as having more attention and memory problems and that, consistent with prior research, more frequent cannabis use was associated with worse memory test performance, though the association was not present between frequency of use and executive function test performance. Additionally, it was found that informant-reported attention problems were associated with poorer performance on two of the executive function cognitive tests. The present findings suggest that individuals who use cannabis more frequently experience noticeable memory and attention problems in everyday life, despite the lack of significant correlation between this functional impairment and cognitive test performance. Informant reports, therefore, may be useful in future research for understanding or predicting cognitive impairment in young adults.
ContributorsCarbajal, Lucia (Author) / Meier, Madeline (Thesis director) / McClure, Samuel (Committee member) / Department of Psychology (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Previous studies suggest an association between depression and anxiety in childhood and adolescence and increased risk for cardiovascular disease later in life. The aim of the present study was to test whether depression and anxiety symptoms in young adulthood were associated with retinal vessel diameter, a subclinical marker of cardiovascular disease. We further tested whether associations for depression were similar to associations for anxiety. Participants completed questionnaires about their depression and anxiety symptoms and underwent retinal imaging. Retinal vessel diameter was assessed using computer software. Results showed no association between depression or anxiety symptoms and retinal vessel diameter, suggesting that retinal vessel diameter may not signal subclinical cardiovascular risk in young adults with symptoms of depression and anxiety.
ContributorsGandee, Katherine Marie (Author) / Meier, Madeline (Thesis director) / Perez, Marisol (Committee member) / Infurna, Frank (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The primary goal of this study was to investigate whether youth from an affluent community showed elevated rates of substance use and associated problems in young adulthood relative to national norms. The secondary goal was to determine if parents’ “containment,” or stringent disciplinary action, of adolescent substance use as measured in Grade 12 could help predict substance use in senior year of college, over and above other parenting factors. The final goal was to assess trends of substance use over time for stability based on categories of participants’ overall levels of use in Grade 12, (low, medium, high). Results indicated that substance use remained elevated into young adulthood, relative to national norms, consistent with extant research involving upper middle class youth. In regression analyses, high parents’ containment was associated with low substance use in senior year of college; however, the inclusion of Grade12 use as a covariate reduced this association with containment such that it was no longer statistically significant. Such results suggest a mediated effect, with Grade 12 substance use mediating the effects of Grade 12 Containment on college senior year substance use. Finally, upper middle class youth were found to remain in their relative substance use group (low, medium, high) as determined at Grade 12 through all four years of college. Taken together, these results emphasized the importance of high school substance use behaviors as a notable risk factor for problematic substance use over time.
ContributorsSmall, Phillip J (Author) / Luthar, Suniya (Thesis advisor) / Meier, Madeline (Committee member) / Infurna, Frank (Committee member) / Arizona State University (Publisher)
Created2015
Description
Alcohol use disorder (AUD) causes immense global burden and has a significant impact on economic and societal functioning. Efficacious treatments for AUDs have been well-established within the literature, however the most commonly accessed treatments for AUD are alcohol-related services, such as self-help groups, outpatient clinics, and detoxification centers. Though studies suggest these services are effective at treating AUDs, there are numerous differences between individuals who receive alcohol-related services and individuals who do not, causing selection bias. Furthermore, current studies of alcohol-related services frequently define recovery outcomes as abstinence, which reduces variability in viable recovery outcomes, such as reduction of drinking behaviors. In addition, reduction in drinking and alcohol-related problems should theoretically have an impact on broader aspects of functioning, such as familial functioning. Improved familial context may reduce risk to family members, who are otherwise at heightened risk for emotional and behavioral problems when living with a family member with AUD. The current study investigated the effect of alcohol-related services on binary and continuous drinking outcomes after eliminating selection bias using multiple propensity score approaches, to identify the best methodology for a high-risk community sample of individuals with AUD. Propensity scores were created using logistic regression approaches and boosted regression trees. Matching, weighting, and subclassification were used, and matching was performed both using greedy and global approaches. Results suggested subclassification was the most successful method for real world alcohol-related services samples with moderate sample size. Moreover, findings demonstrated that boosted regression approaches were less successful than logistic regression approaches at minimizing the effects of selection bias on known confounding variables that are highly related to group selection. In addition, after removing the effects of selection bias, there were no significant difference between participants who received alcohol-related services and the comparison control group on drinking or family functioning, though both groups reduced drinking from pre- to post-alcohol-related services receipt. Findings suggest careful selection of quasi-experimental methods is warranted in real-world samples, to ensure optimal removal of selection bias. Moreover, future studies should continue to clarify the profile of individual that benefits from alcohol-related services to inform intervention efforts.
ContributorsSternberg, Ariel (Author) / Chassin, Laurie (Thesis advisor) / Corbin, William (Committee member) / Meier, Madeline (Committee member) / Grimm, Kevin (Committee member) / Arizona State University (Publisher)
Created2021
Description
Despite the established co-prevalence of substance use (SU) and disordered eating (DE), few longitudinal studies have sought to examine their shared development. Findings have been inconsistent within the extant literature. This may be attributable in part to several methodological aspects, including overlooking distinct psychopharmacological properties of common substances of abuse, examining only between-person relations, and failing to account for shared risk factors. The current study sought to address these gaps by applying latent curve models with structured residuals (LCM-SR) to a preexisting, national sample of adolescent girls followed into adulthood, Add Health. In Aim 1, between-person effects examined the simultaneous development of alcohol, tobacco, and marijuana use and DE behaviors in substance-specific models. In Aim 2, bivariate latent curve models were expanded to account for within-person effects (LCM-SR) in order to examine the potentially bidirectional, prospective relationship between use of a specific substance and DE. Lastly, models accounted for shared developmental risk factors. Findings of the current study demonstrate preliminary evidence of substance-specific effects with DE emerging in adolescence. Across model-building steps, DE engagement in early adolescence was significantly associated with growth in tobacco use and marginally associated with marijuana use. Appetitive side-effects of both substances may link use with DE behaviors and enhance instrumental use for weight control. Significant associations did not emerge between alcohol and DE, and results of the conditional model indicate this co-occurrence is best explained by third variable mechanisms. Implications for prevention are discussed.
ContributorsBruening, Amanda B (Author) / Corbin, William (Thesis advisor) / Chassin, Laurie (Committee member) / Meier, Madeline (Committee member) / McNeish, Daniel (Committee member) / Arizona State University (Publisher)
Created2021