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RAGE Deletion Reduces Myocardial Injury in High-Fat Diet-Fed Mice

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The development of the Diabetic Physiological state is influenced by the Receptor for Advanced Glycation End Products (RAGE). This receptor was discovered in 1992, and the accumulation of research on this subject has been extensive. Structural characterization studies of the RAGE protein have shown that it is a transmembrane protein…

The development of the Diabetic Physiological state is influenced by the Receptor for Advanced Glycation End Products (RAGE). This receptor was discovered in 1992, and the accumulation of research on this subject has been extensive. Structural characterization studies of the RAGE protein have shown that it is a transmembrane protein that binds a number of different motile ligands. The diversity of ligands that can attach to the binding domain is the primary factor that allows for RAGE to exhibit its wide-range effects on host cells. Two different studies were completed: one study dealt with the role of IAPP in beta cell death, and the second study was related to RAGE influence on cardiomyocytes and, more specifically, it was related to cardiac cell death. After the completion of the two studies, a comprehensive report was written for each topic. The two papers were merged into a single document. Molecular studies are important for understanding the underlying mechanisms that motivate pathophysiological presentation. In addition to a molecular understanding of the development of diabetes, a clinical research study was completed through the examination of appropriate literature sources. This clinical aspect allowed for the progression of different phases in the research process. A relationship between vinegar and lower plasma glucose was found. The exact mechanism behind this relationship will be studied in the future.
ContributorsGonzalez, Matthew Joseph (Author) / Johnston, Carol (Thesis director) / Collins, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor)
Created2015-05
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Implementing Raised Bed Gardens as a Form of a Health Intervention, Specifically in Habitat for Humanity Homes

Description
The rise of the average life span in developed countries in the past couple of centuries can be traced back to implementation of relatively simple health interventions. Also, accompanying the rise in the average life span is the rise in chronic disease. Current treatments for chronic disease is often very…

The rise of the average life span in developed countries in the past couple of centuries can be traced back to implementation of relatively simple health interventions. Also, accompanying the rise in the average life span is the rise in chronic disease. Current treatments for chronic disease is often very costly and only offers partial alleviation to the problem. Preventing the chronic disease upstream of the problem happening in the first place is both significantly more effective and cheaper. Raised bed gardening helps prevent chronic disease processes from happening through mental, physical, and nutritional health benefits. A subset of people that would particularly benefit from raised bed gardening would be families receiving homes from Habitat from Humanity for many different reasons including susceptibility to a gardening intervention, availability of materials, and location of the homes. A guide to implement these gardens is provided which is supplemented with a combination of research and personal experience.
ContributorsBarker, Kenneth Holland (Author) / Collins, Michael (Thesis director) / Kizer, Elizabeth (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05