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Description
Schizophrenia affects 1.1% of the population worldwide. Schizophrenia is a complex, multifactorial disorder. Stress can trigger psychotic episodes and exacerbate schizophrenic symptoms. For humans, one gene implicated in stress and schizophrenia in humans is the early growth response 3 (EGR3). Patients with genomic variations in EGR3 have reduced levels of

Schizophrenia affects 1.1% of the population worldwide. Schizophrenia is a complex, multifactorial disorder. Stress can trigger psychotic episodes and exacerbate schizophrenic symptoms. For humans, one gene implicated in stress and schizophrenia in humans is the early growth response 3 (EGR3). Patients with genomic variations in EGR3 have reduced levels of EGR3 in the prefrontal brain region compared with healthy patients. Schizophrenic patients also have less serotonin 2A receptor (5HT2AR), which is coded by the gene Htr2a, in their prefrontal cortex. Mice that are Egr3-deficient also have decreased levels of 5HT2AR, suggesting that Egr3 may be involved in the regulation of 5HT2AR. The purpose of the experiment is to determine if EGR3 binds to the Htr2a gene promoter region by using a Chromatin immunoprecipitation (ChIP) assay. We will use ECS to increase EGR3 expression. Previously we have identified two upstream sites of interest where EGR3 potentially binds to the Htr2a gene, one which is distal and one proximal to the transcription start site. After ECS, increased binding is seen in the Htr2a distal region with EGR3 via the ChIP assay. Increased binding was not observed at either of the promoter sites; however, the t-test comparing the distal site of the ECS and the No ECS groups to have a p-value of 0.056, suggesting that increasing the number of animals (n=7) could possibly give a more accurate representation to test our hypothesis. However, the experiment still suggests increased expression and that EGR3 may bind to the distal site of Htr2a. Keywords: stress, environment, genetics, schizophrenia, EGR3, chromatin immunoprecipitation
ContributorsMishra, Abhinav (Author) / Buetow, Kenneth (Thesis director) / Gallitano, Amelia (Committee member) / Zhao, Xiuli (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Life Sciences (Contributor)
Created2015-05
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Description
Faërie exists in the mythology and literature of northwestern Europe as a spiritual Otherworld, a land of immortal beauty just tangential to our own. This project explored multiple conceptions of Faërie and their common association with things that have been lost. The pattern that emerged is one in which the

Faërie exists in the mythology and literature of northwestern Europe as a spiritual Otherworld, a land of immortal beauty just tangential to our own. This project explored multiple conceptions of Faërie and their common association with things that have been lost. The pattern that emerged is one in which the Otherworld is not merely linked to lost things, but becomes a way of preserving and rediscovering them. Faërie embodies the hope that things lost live on, and can be found again.
ContributorsBell, Andrew Roos (Author) / Baldini, Cajsa (Thesis director) / Maring, Heather (Committee member) / Foy, Joseph (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / Department of English (Contributor)
Created2013-05
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Description
This paper elaborates on the considerations of organizing a democratic deliberation. It addresses issues of topic, length, defining consensus, and how to effectively translate deliberative theory into a concrete, results-producing event. The paper presents this information in the context of the body of academic work on deliberation plus the author's

This paper elaborates on the considerations of organizing a democratic deliberation. It addresses issues of topic, length, defining consensus, and how to effectively translate deliberative theory into a concrete, results-producing event. The paper presents this information in the context of the body of academic work on deliberation plus the author's own experience organizing two successful deliberative events.
ContributorsReich, Jennifer Marie (Author) / Crittenden, William J. (Thesis director) / Simhony, Avital (Committee member) / Varrato, Rory (Committee member) / Barrett, The Honors College (Contributor) / Public Participation in Government (Contributor) / School of Politics and Global Studies (Contributor)
Created2013-05
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DescriptionA nonprofit organization / grassroots movement capturing the voice of a generation of young Arizonans
Created2014-05
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Description
Levels of civic engagement among young adults has been an increasing concern for social scientists. Young adults are showing lower amounts of civic engagement than in the past, and this has translated into a concern for the democratic process in the United States. This thesis looks to analyze the national

Levels of civic engagement among young adults has been an increasing concern for social scientists. Young adults are showing lower amounts of civic engagement than in the past, and this has translated into a concern for the democratic process in the United States. This thesis looks to analyze the national downward trend of civic engagement at the collegiate level, specifically at Arizona State University. To make this 71,000-student community more manageable, this analysis will specifically look at one community within Arizona State: Fraternity and Sorority Life. The different groups within Fraternity and Sorority Life at Arizona State University provide an all-encompassing view of civic engagement through participation in various activities and events. An annual report published by the office of Fraternity and Sorority Life will show the effect of the number of educational programs, number of charitable donations, and amount of outside campus involvement has on civic engagement. Looking at pieces of work like Putnam’s Bowling Alone and Hero’s Racial Diversity and Social Capital, this thesis analyzes the associations of these organizations and how that translates into civic engagement and social capital. In addition, we subsequently question Putnam’s analysis, and attempt to apply these critiques to Arizona State University’s collegiate community. This thesis looks at the impact of historically cultural vs historically social groups. The results of this study show that the historically cultural groups are demonstrating higher levels of civic engagement based on their horizontal associations. This information can be used to better understand young adult’s impact on their surrounding community, as well as how the makeup and functioning of groups can influence levels of social capital and civic engagement.
ContributorsHertle, Sydnee Avery (Author) / Thomson, Henry (Thesis director) / Hero, Rodney (Committee member) / School of Politics and Global Studies (Contributor) / Department of Economics (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
This publication addresses the development of civic engagement programs in the past few decades. While successful in increasing what was perceived as a serious lack of civic engagement among youth, the movement has failed to address a key aspect of civic engagement: political engagement. Although trends have shown that the

This publication addresses the development of civic engagement programs in the past few decades. While successful in increasing what was perceived as a serious lack of civic engagement among youth, the movement has failed to address a key aspect of civic engagement: political engagement. Although trends have shown that the youth are much more interested in alternative forms of engagement, it is important for the success of democracy and sustaining political structures that the youth are given tools to become engaged in traditional forms of government. This paper, by analyzing data from various academic papers, will look into successful policy initiatives to increase political engagement at universities. Furthermore, the paper will look into current programs at Arizona State University (ASU) based on a criterion created from the academic resources to gauge ASU's standings. The paper will conclude with a proposal for a future ASU program. The program will be an expansion of the current ASU Experience course required of freshmen to implement a political engagement preparatory curriculum.
ContributorsJeong, Yijee (Author) / Woodall, Gina (Thesis director) / Simhony, Avital (Committee member) / Jones, Ruth (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / Sandra Day O'Connor College of Law (Contributor)
Created2013-05
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Description
This study examines sustainable development concerns as an essential part of the Costa Rican national identity. Interviews with ecotourism industry workers and an analysis of pertinent news articles shine light on the Costa Rican citizen's perspective of sustainable development, showing that in spite of current initiatives industry workers still have

This study examines sustainable development concerns as an essential part of the Costa Rican national identity. Interviews with ecotourism industry workers and an analysis of pertinent news articles shine light on the Costa Rican citizen's perspective of sustainable development, showing that in spite of current initiatives industry workers still have unmet environmental and economic concerns, and that the general public is both passionately interested and personally invested in the topic.
ContributorsHoward, Kalyn Marie (Author) / Puleo, Thomas (Thesis director) / Larson, Elizabeth (Committee member) / Hunter, Joel (Committee member) / Barrett, The Honors College (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Politics and Global Studies (Contributor)
Created2013-05
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Description

This study attempts to answer the following questions: Is civic engagement a social activity among 18-25-year-old college students? How are opinions regarding civic and political engagement impacted by social settings? How are civic and political engagement atmospheres impacted by social distancing and isolation protocol? In this study, the researcher hypothesized

This study attempts to answer the following questions: Is civic engagement a social activity among 18-25-year-old college students? How are opinions regarding civic and political engagement impacted by social settings? How are civic and political engagement atmospheres impacted by social distancing and isolation protocol? In this study, the researcher hypothesized that civic and political engagement are social activities, so they are therefore susceptible to changing social context. Since the COVID-19 pandemic disrupted typical social interaction through social distancing and isolation protocol, the researcher hypothesized that it also altered mechanisms of civic and political engagement. Political engagement would be more prevalent among students who participate with others even in pandemic conditions that may otherwise decrease close contact and social interactions. These findings seem to disagree with the literature that suggests young people are supplanting voting with other forms of engagement (Zukin et al., 2006). Rather, the “complexity” denoted in interviews and in reports of engagements on the pre- and post-election surveys suggests that young people are voting as well as dedicating their time to other activities. Voting does seem to be a social activity according to the interviews, poll observations, and the surveys. This is consistent with the literature regarding social norms and group predictors. However, this social aspect of engagement seems to manifest in a wider variety of formats that originally thought. Finally, students continued to engage in the context of the pandemic that surrounded the election in question. It seems that the formats through which students engaged have expanded to maintain the connections that are crucial to civic participation.

ContributorsBrown, Kelli A. (Author) / Cook-Davis, Alison (Thesis director) / Lewis, Paul (Committee member) / Schuster, Roseanne (Committee member) / School of Politics and Global Studies (Contributor) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / School of Social Transformation (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Lithium ion batteries are quintessential components of modern life. They are used to power smart devices — phones, tablets, laptops, and are rapidly becoming major elements in the automotive industry. Demand projections for lithium are skyrocketing with production struggling to keep up pace. This drive is due mostly to the

Lithium ion batteries are quintessential components of modern life. They are used to power smart devices — phones, tablets, laptops, and are rapidly becoming major elements in the automotive industry. Demand projections for lithium are skyrocketing with production struggling to keep up pace. This drive is due mostly to the rapid adoption of electric vehicles; sales of electric vehicles in 2020 are more than double what they were only a year prior. With such staggering growth it is important to understand how lithium is sourced and what that means for the environment. Will production even be capable of meeting the demand as more industries make use of this valuable element? How will the environmental impact of lithium affect growth? This thesis attempts to answer these questions as the world looks to a decade of rapid growth for lithium ion batteries.

ContributorsMelton, John (Author) / Brian, Jennifer (Thesis director) / Karwat, Darshawn (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

This project offers an argument that isolates several major forces that it contends pose a critical threat to the endurance of modern American democracy. It evaluates modern and classic political philosophy to identify the prerequisites for a stable democracy, identifying and defining voter education and participation as necessary contributors to

This project offers an argument that isolates several major forces that it contends pose a critical threat to the endurance of modern American democracy. It evaluates modern and classic political philosophy to identify the prerequisites for a stable democracy, identifying and defining voter education and participation as necessary contributors to civic engagement. It provides a socio-legal framework for evaluating four phenomena that have shifted in their impact on politics over the past 20 years: the roles of money and media in politics, as well as disenfranchisement by gerrymandering and by felon voting restrictions. It demonstrates how each has a new and worsening impact on voter education and/or participation, thus threatening the continued existence of modern American democracy.

ContributorsBurnquist, Andrew (Co-author) / Morote, Nicole (Co-author) / Mason, Maria (Co-author) / Affolter, Jacob (Thesis director) / Hoekstra, Valeria (Committee member) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05