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The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA

The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA shell surrounding the PLGA core. The microparticles were loaded with bovine serum albumin (BSA) and different volumes of ethanol were added to the PLA shell phase to alter the porosity and release characteristics of the BSA. Different amounts of ethanol varied the total loading percentage of the BSA, the release profile, surface morphology, size distribution, and the localization of the protein within the particles. Scanning electron microscopy images detailed the surface morphology of the different particles. Loading the particles with fluorescently tagged insulin and imaging the particles through confocal microscopy supported the localization of the protein inside the particle. The study suggest that ethanol alters the release characteristics of the loaded BSA encapsulated in the microparticles supporting the use of a polar, protic solvent as a tool for tuning the delayed release profile of biological proteins.
ContributorsFauer, Chase Alexander (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
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Description

For our project, we explored the growth of the ASU BioDesign Clinical Testing Laboratory (ABCTL) from a standard university research lab to a COVID-19 testing facility through a business lens. The lab has pioneered the saliva-test in the Western United States. This thesis analyzes the laboratory from various business concepts

For our project, we explored the growth of the ASU BioDesign Clinical Testing Laboratory (ABCTL) from a standard university research lab to a COVID-19 testing facility through a business lens. The lab has pioneered the saliva-test in the Western United States. This thesis analyzes the laboratory from various business concepts and aspects. The business agility of the lab and it’s quickness to innovation has allowed the lab to enjoy great success. Looking into the future, the laboratory has a promising future and will need to answer many questions to remain the premier COVID-19 testing institution in Arizona.

ContributorsEnglish, Corinne (Co-author) / Cosgrove, Samuel (Co-author) / Mattson, Kyle (Co-author) / Agee, Claire (Co-author) / Qian, Michael (Co-author) / Compton, Carolyn (Thesis director) / Schneller, Eugene (Committee member) / Department of Information Systems (Contributor) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Over the last few decades, sustainability has become a great focus for individuals as well as businesses globally. The focus of this study was to understand why businesses purchase certain office supplies and why they may not be choosing to purchase the most sustainable options. The research question asked, “why

Over the last few decades, sustainability has become a great focus for individuals as well as businesses globally. The focus of this study was to understand why businesses purchase certain office supplies and why they may not be choosing to purchase the most sustainable options. The research question asked, “why are certain businesses reluctant to make positive, sustainable changes to their usage of office materials in their workplace environments?” Most companies do not look for alternatives that would benefit the environment when purchasing products for their office space. The reasons behind this hesitancy to change was studied through current literature on the topic as well as interviews conducted with Office Managers of several different businesses. Comparisons were made between each businesses’ decision patterns in order to find the root cause or causes of why companies do not choose more sustainable options when purchasing products for their workspaces. The interviews revealed that cost and quality are the most important factors these businesses take into consideration when purchasing office supplies. While some companies have looked into alternative products for their supplies, they ultimately choose to still purchase the less sustainable option. This is because the less sustainable option is often cheaper, and the company knows what quality to expect for the item. Overall, all of the Office Managers who were interviewed acknowledged some sort of sustainable practice that their company was taking part in, even if it did not directly relate to the types of office supplies that they purchase. This inclusion of general sustainable practices demonstrates how businesses are making efforts one way or another towards a more sustainable future. Therefore, this awareness to sustainability suggests that most, if not all businesses will eventually end up purchasing sustainable alternatives for their office supplies. However, the timeframe for which this occurs for each company will likely vary.

ContributorsOberlander, Rachel Lynn (Author) / Kappes, Janelle (Thesis director) / Augustin-Behravesh, Shirley-Ann (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Earth and Space Exploration (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

This thesis details the impact of sustainable practices, or lack thereof, among IKEA and Chanel. It takes these principles and analyzes the effectiveness of them and works to implement them across industries and companies of different sizes and organizational structures.

ContributorsL'Heureux, Kendall James (Author) / Foote, Nicola (Thesis director) / Alcantara, Christiane (Committee member) / Department of Marketing (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Polymer drug delivery system offers a key to a glaring issue in modern administration routes of drugs and biologics. Poly(lactic-co-glycolic acid) (PLGA) can be used to encapsulate drugs and biologics and deliver them into the patient, which allows high local concentration (compared to current treatment methods), protection of the cargo

Polymer drug delivery system offers a key to a glaring issue in modern administration routes of drugs and biologics. Poly(lactic-co-glycolic acid) (PLGA) can be used to encapsulate drugs and biologics and deliver them into the patient, which allows high local concentration (compared to current treatment methods), protection of the cargo from the bodily environment, and reduction in systemic side effects. This experiment used a single emulsion technique to encapsulate L-tyrosine in PLGA microparticles and UV spectrophotometry to analyze the drug release over a period of one week. The release assay found that for the tested samples, the released amount is distinct initially, but is about the same after 4 days, and they generally follow the same normalized percent released pattern. The experiment could continue with testing more samples, test the same samples for a longer duration, and look into higher w/w concentrations such as 20% or 50%.

ContributorsSeo, Jinpyo (Author) / Vernon, Brent (Thesis director) / Pal, Amrita (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.

ContributorsHan, Priscilla (Author) / Vernon, Brent (Thesis director) / Nickle, Jacob (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

In the current age of global climate crisis, corporations must confront the rising pressure to mitigate their environmental impacts. The goal of this research paper is to provide corporations with a resource to manage waste through the implementation of a circular economy and by increasing Corporate Social Responsibility (CSR). Navigating

In the current age of global climate crisis, corporations must confront the rising pressure to mitigate their environmental impacts. The goal of this research paper is to provide corporations with a resource to manage waste through the implementation of a circular economy and by increasing Corporate Social Responsibility (CSR). Navigating this large and complex system required the use of various methodologies including: the investigation of the relationships between waste management systems and sustainable development across major companies; literature reviews of scholarly articles about CSR, circular economies, recycling, and releases of company reports on sustainable development and financials. Lastly, interviews and a survey were conducted to gain deeper insight into the problems that make circular economies so difficult to achieve at scale.

ContributorsBird, Alex William (Author) / Heller, Cheryl (Thesis director) / Trujillo, Rhett (Committee member) / Department of Finance (Contributor) / Department of Management and Entrepreneurship (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

Honored Brow is a local, non-profit, start-up business that specializes in brow lamination and lash lifts with tinting services. The business is founded and operated by four students enrolled in Arizona State University, Barrett, The Honors College. Honored Brow’s mission, through the thesis project, is to connect and provide brow

Honored Brow is a local, non-profit, start-up business that specializes in brow lamination and lash lifts with tinting services. The business is founded and operated by four students enrolled in Arizona State University, Barrett, The Honors College. Honored Brow’s mission, through the thesis project, is to connect and provide brow and lash services to enhance natural beauty and empower women. This project was completed as part of Founders Lab.

ContributorsSpencer, Brintley (Author) / Ampadu-Siaw, Rose (Co-author) / Knowles, Nicholas (Co-author) / Roland, Carson (Co-author) / Byrne, Jared (Thesis director) / Boeh, Morgan (Committee member) / Thirunagari, Samay (Committee member) / Thomasson, Anna (Committee member) / Asselyn, Dakota (Committee member) / Challa, Anirudh (Committee member) / Gajera, Rajanikant (Committee member) / Myneni, Karthik (Committee member) / Yunus, Faseeh (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2023-05
DescriptionBusiness Plan and Purchase Agreement for a private swim lesson business, FH Kids Academy.
Created2023-12
Description
This guide is intended to give the reader a breakdown of the expectations and customs of the professional French environment. Whether one has French suppliers, partners, coworkers, or employees, it is important to understand the culture that guides their expectations and actions. This guide requires no previous knowledge of French

This guide is intended to give the reader a breakdown of the expectations and customs of the professional French environment. Whether one has French suppliers, partners, coworkers, or employees, it is important to understand the culture that guides their expectations and actions. This guide requires no previous knowledge of French language or culture and is meant to be an introduction to the topic.
ContributorsNicholls, Olivia G (Author) / Bahtchevanova, Mariana (Thesis director) / Winter, Marie (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of International Letters and Cultures (Contributor) / Department of Marketing (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05