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Electrical neural activity detection and tracking have many applications in medical research and brain computer interface technologies. In this thesis, we focus on the development of advanced signal processing algorithms to track neural activity and on the mapping of these algorithms onto hardware to enable real-time tracking. At the heart

Electrical neural activity detection and tracking have many applications in medical research and brain computer interface technologies. In this thesis, we focus on the development of advanced signal processing algorithms to track neural activity and on the mapping of these algorithms onto hardware to enable real-time tracking. At the heart of these algorithms is particle filtering (PF), a sequential Monte Carlo technique used to estimate the unknown parameters of dynamic systems. First, we analyze the bottlenecks in existing PF algorithms, and we propose a new parallel PF (PPF) algorithm based on the independent Metropolis-Hastings (IMH) algorithm. We show that the proposed PPF-IMH algorithm improves the root mean-squared error (RMSE) estimation performance, and we demonstrate that a parallel implementation of the algorithm results in significant reduction in inter-processor communication. We apply our implementation on a Xilinx Virtex-5 field programmable gate array (FPGA) platform to demonstrate that, for a one-dimensional problem, the PPF-IMH architecture with four processing elements and 1,000 particles can process input samples at 170 kHz by using less than 5% FPGA resources. We also apply the proposed PPF-IMH to waveform-agile sensing to achieve real-time tracking of dynamic targets with high RMSE tracking performance. We next integrate the PPF-IMH algorithm to track the dynamic parameters in neural sensing when the number of neural dipole sources is known. We analyze the computational complexity of a PF based method and propose the use of multiple particle filtering (MPF) to reduce the complexity. We demonstrate the improved performance of MPF using numerical simulations with both synthetic and real data. We also propose an FPGA implementation of the MPF algorithm and show that the implementation supports real-time tracking. For the more realistic scenario of automatically estimating an unknown number of time-varying neural dipole sources, we propose a new approach based on the probability hypothesis density filtering (PHDF) algorithm. The PHDF is implemented using particle filtering (PF-PHDF), and it is applied in a closed-loop to first estimate the number of dipole sources and then their corresponding amplitude, location and orientation parameters. We demonstrate the improved tracking performance of the proposed PF-PHDF algorithm and map it onto a Xilinx Virtex-5 FPGA platform to show its real-time implementation potential. Finally, we propose the use of sensor scheduling and compressive sensing techniques to reduce the number of active sensors, and thus overall power consumption, of electroencephalography (EEG) systems. We propose an efficient sensor scheduling algorithm which adaptively configures EEG sensors at each measurement time interval to reduce the number of sensors needed for accurate tracking. We combine the sensor scheduling method with PF-PHDF and implement the system on an FPGA platform to achieve real-time tracking. We also investigate the sparsity of EEG signals and integrate compressive sensing with PF to estimate neural activity. Simulation results show that both sensor scheduling and compressive sensing based methods achieve comparable tracking performance with significantly reduced number of sensors.
ContributorsMiao, Lifeng (Author) / Chakrabarti, Chaitali (Thesis advisor) / Papandreou-Suppappola, Antonia (Thesis advisor) / Zhang, Junshan (Committee member) / Bliss, Daniel (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2013
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Description
This thesis investigates three different resource allocation problems, aiming to achieve two common goals: i) adaptivity to a fast-changing environment, ii) distribution of the computation tasks to achieve a favorable solution. The motivation for this work relies on the modern-era proliferation of sensors and devices, in the Data Acquisition Systems

This thesis investigates three different resource allocation problems, aiming to achieve two common goals: i) adaptivity to a fast-changing environment, ii) distribution of the computation tasks to achieve a favorable solution. The motivation for this work relies on the modern-era proliferation of sensors and devices, in the Data Acquisition Systems (DAS) layer of the Internet of Things (IoT) architecture. To avoid congestion and enable low-latency services, limits have to be imposed on the amount of decisions that can be centralized (i.e. solved in the ``cloud") and/or amount of control information that devices can exchange. This has been the motivation to develop i) a lightweight PHY Layer protocol for time synchronization and scheduling in Wireless Sensor Networks (WSNs), ii) an adaptive receiver that enables Sub-Nyquist sampling, for efficient spectrum sensing at high frequencies, and iii) an SDN-scheme for resource-sharing across different technologies and operators, to harmoniously and holistically respond to fluctuations in demands at the eNodeB' s layer.

The proposed solution for time synchronization and scheduling is a new protocol, called PulseSS, which is completely event-driven and is inspired by biological networks. The results on convergence and accuracy for locally connected networks, presented in this thesis, constitute the theoretical foundation for the protocol in terms of performance guarantee. The derived limits provided guidelines for ad-hoc solutions in the actual implementation of the protocol.

The proposed receiver for Compressive Spectrum Sensing (CSS) aims at tackling the noise folding phenomenon, e.g., the accumulation of noise from different sub-bands that are folded, prior to sampling and baseband processing, when an analog front-end aliasing mixer is utilized.

The sensing phase design has been conducted via a utility maximization approach, thus the scheme derived has been called Cognitive Utility Maximization Multiple Access (CUMMA).

The framework described in the last part of the thesis is inspired by stochastic network optimization tools and dynamics.

While convergence of the proposed approach remains an open problem, the numerical results here presented suggest the capability of the algorithm to handle traffic fluctuations across operators, while respecting different time and economic constraints.

The scheme has been named Decomposition of Infrastructure-based Dynamic Resource Allocation (DIDRA).
ContributorsFerrari, Lorenzo (Author) / Scaglione, Anna (Thesis advisor) / Bliss, Daniel (Committee member) / Ying, Lei (Committee member) / Reisslein, Martin (Committee member) / Arizona State University (Publisher)
Created2017
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Description
Biological and biomedical measurements, when adequately analyzed and processed, can be used to impart quantitative diagnosis during primary health care consultation to improve patient adherence to recommended treatments. For example, analyzing neural recordings from neurostimulators implanted in patients with neurological disorders can be used by a physician to adjust detrimental

Biological and biomedical measurements, when adequately analyzed and processed, can be used to impart quantitative diagnosis during primary health care consultation to improve patient adherence to recommended treatments. For example, analyzing neural recordings from neurostimulators implanted in patients with neurological disorders can be used by a physician to adjust detrimental stimulation parameters to improve treatment. As another example, biosequences, such as sequences from peptide microarrays obtained from a biological sample, can potentially provide pre-symptomatic diagnosis for infectious diseases when processed to associate antibodies to specific pathogens or infectious agents. This work proposes advanced statistical signal processing and machine learning methodologies to assess neurostimulation from neural recordings and to extract diagnostic information from biosequences.

For locating specific cognitive and behavioral information in different regions of the brain, neural recordings are processed using sequential Bayesian filtering methods to detect and estimate both the number of neural sources and their corresponding parameters. Time-frequency based feature selection algorithms are combined with adaptive machine learning approaches to suppress physiological and non-physiological artifacts present in neural recordings. Adaptive processing and unsupervised clustering methods applied to neural recordings are also used to suppress neurostimulation artifacts and classify between various behavior tasks to assess the level of neurostimulation in patients.

For pathogen detection and identification, random peptide sequences and their properties are first uniquely mapped to highly-localized signals and their corresponding parameters in the time-frequency plane. Time-frequency signal processing methods are then applied to estimate antigenic determinants or epitope candidates for detecting and identifying potential pathogens.
ContributorsMaurer, Alexander Joseph (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Chakrabarti, Chaitali (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2016
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Description
In this dissertation, I propose potential techniques to improve the quality-of-service (QoS) of real-time applications in cognitive radio (CR) systems. Unlike best-effort applications, real-time applications, such as audio and video, have a QoS that need to be met. There are two different frameworks that are used to study the QoS

In this dissertation, I propose potential techniques to improve the quality-of-service (QoS) of real-time applications in cognitive radio (CR) systems. Unlike best-effort applications, real-time applications, such as audio and video, have a QoS that need to be met. There are two different frameworks that are used to study the QoS in the literature, namely, the average-delay and the hard-deadline frameworks. In the former, the scheduling algorithm has to guarantee that the packet's average delay is below a prespecified threshold while the latter imposes a hard deadline on each packet in the system. In this dissertation, I present joint power allocation and scheduling algorithms for each framework and show their applications in CR systems which are known to have strict power limitations so as to protect the licensed users from interference.

A common aspect of the two frameworks is the packet service time. Thus, the effect of multiple channels on the service time is studied first. The problem is formulated as an optimal stopping rule problem where it is required to decide at which channel the SU should stop sensing and begin transmission. I provide a closed-form expression for this optimal stopping rule and the optimal transmission power of secondary user (SU).

The average-delay framework is then presented in a single CR channel system with a base station (BS) that schedules the SUs to minimize the average delay while protecting the primary users (PUs) from harmful interference. One of the contributions of the proposed algorithm is its suitability for heterogeneous-channels systems where users with statistically low channel quality suffer worse delay performances. The proposed algorithm guarantees the prespecified delay performance to each SU without violating the PU's interference constraint.

Finally, in the hard-deadline framework, I propose three algorithms that maximize the system's throughput while guaranteeing the required percentage of packets to be transmitted by their deadlines. The proposed algorithms work in heterogeneous systems where the BS is serving different types of users having real-time (RT) data and non-real-time (NRT) data. I show that two of the proposed algorithms have the low complexity where the power policies of both the RT and NRT users are in closed-form expressions and a low-complexity scheduler.
ContributorsEwaisha, Ahmed Emad (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Ying, Lei (Committee member) / Bliss, Daniel (Committee member) / Kosut, Oliver (Committee member) / Arizona State University (Publisher)
Created2016