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- Genre: Doctoral Dissertation
Description
Many manmade chemicals used in consumer products are ultimately washed down the drain and are collected in municipal sewers. Efficient chemical monitoring at wastewater treatment (WWT) plants thus may provide up-to-date information on chemical usage rates for epidemiological assessments. The objective of the present study was to extrapolate this concept, termed 'sewage epidemiology', to include municipal sewage sludge (MSS) in identifying and prioritizing contaminants of emerging concern (CECs). To test this the following specific aims were defined: i) to screen and identify CECs in nationally representative samples of MSS and to provide nationwide inventories of CECs in U.S. MSS; ii) to investigate the fate and persistence in MSS-amended soils, of sludge-borne hydrophobic CECs; and iii) to develop an analytical tool relying on contaminant levels in MSS as an indicator for identifying and prioritizing hydrophobic CECs. Chemicals that are primarily discharged to the sewage systems (alkylphenol surfactants) and widespread persistent organohalogen pollutants (perfluorochemicals and brominated flame retardants) were analyzed in nationally representative MSS samples. A meta-analysis showed that CECs contribute about 0.04-0.15% to the total dry mass of MSS, a mass equivalent of 2,700-7,900 metric tonnes of chemicals annually. An analysis of archived mesocoms from a sludge weathering study showed that 64 CECs persisted in MSS/soil mixtures over the course of the experiment, with half-lives ranging between 224 and >990 days; these results suggest an inherent persistence of CECs that accumulate in MSS. A comparison of the spectrum of chemicals (n=52) analyzed in nationally representative biological specimens from humans and MSS revealed 70% overlap. This observed co-occurrence of contaminants in both matrices suggests that MSS may serve as an indicator for ongoing human exposures and body burdens of pollutants in humans. In conclusion, I posit that this novel approach in sewage epidemiology may serve to pre-screen and prioritize the several thousands of known or suspected CECs to identify those that are most prone to pose a risk to human health and the environment.
ContributorsVenkatesan, Arjunkrishna (Author) / Halden, Rolf U. (Thesis advisor) / Westerhoff, Paul (Committee member) / Fox, Peter (Committee member) / Arizona State University (Publisher)
Created2013
Description
Research has demonstrated that temperature and relative humidity substantially influence overall perceptions of indoor air quality (Fang, Clausen, & Fanger, 1998). This finding places temperature quality as a high priority, especially for vulnerable adults over 60. Temperature extremes and fluctuation, as well as the perception of those conditions, affect physical performance, thermal comfort and health of older adults (Chatonnet & Cabanac, 1965, pp. 185-6; Fumiharu, Watanabe, Park, Shephard, & Aoyagi, 2005; Heijs & Stringer, 1988). The American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE) and the International Organization for Standardization (ISO) have developed thermal-comfort standards for working-age, healthy individuals. None of these standards address the physiological and psychological needs of older adults (ASHRAE Standard 55, 2010; ISO-7730, 2005). This dissertation investigates the impacts of thermal conditions on self-reported health and perceived comfort for older adults, hypothesizing that warmer and more-table indoor thermal conditions will increase the health and perceived comfort of these adults. To this end, a new set of thermal comfort metrics was designed and tested to address the thermal preferences of older adults. The SENIOR COMFORT Metrics 2013 outlined new thresholds for optimal indoor high and low temperatures and set limits on thermal variability over time based on the ASHRAE-55 2010 model. This study was conducted at Sunnyslope Manor, a multi-unit, public-housing complex in the North Phoenix. Nearly 60% (76 of 118) of the residents (aged 62-82) were interviewed using a 110-question, self-reporting survey in 73 apartment units. A total of 40 questions and 20 sub-questions addressing perceptions of comfort, pain, sleep patterns, injuries, and mood were extracted from this larger health condition survey to assess health and thermal comfort. Indoor environmental thermal measurements included temperature in three locations: kitchen, living area, and bedroom and data were recorded every 15 minutes over 5 full days and 448 points. Study results start to indicate that older adults for Sunnyslope Manor preferred temperatures between 76 and 82.5 degrees Fahrenheit and that lower temperatures as outlined by ASHRAE-55 2010 increases the rate of injuries and mood changes in older adults among other findings.
ContributorsFonseca, Ernesto (Author) / Bryan, Harvey (Thesis advisor) / Ahrentzen, Sherry (Committee member) / Shea, Kimberly (Committee member) / Arizona State University (Publisher)
Created2013
Description
Growers and the USDA showed increasing favor for agricultural chemicals over cultural and biological forms of pest control through the first half of the twentieth century. With the introduction of DDT and other synthetic chemicals to commercial markets in the post-World War II era, pesticides became entrenched as the primary form of pest control in the industrial agriculture production system. Despite accumulating evidence that some pesticides posed a threat to human and environmental health, growers and government exercised path-dependent behavior in the development and implementation of pest control strategies. As pests developed resistance to regimens of agricultural chemicals, growers applied pesticides with greater toxicity in higher volumes to their fields with little consideration for the unintended consequences of using the economic poisons. Consequently, pressure from non-governmental organizations proved a necessary predicate for pesticide reform. This dissertation uses a series of case studies to examine the role of non-governmental organizations, particularly environmental organizations and farmworker groups, in pesticide reform from 1962 to 2011. For nearly fifty years, these groups served as educators, communicating scientific and experiential information about the adverse effects of pesticides on human health and environment to the public, and built support for the amendment of pesticide policies and the alteration of pesticide use practices. Their efforts led to the passage of more stringent regulations to better protect farmworkers, the public, and the environment. Environmental organizations and farmworker groups also acted as watchdogs, monitoring the activity of regulatory agencies and bringing suit when necessary to ensure that they fulfilled their responsibilities to the public. This dissertation will build on previous scholarly work to show increasing collaboration between farmworker groups and environmental organizations. It argues that the organizations shared a common concern about the effects of pesticides on human health, which enabled bridge-builders within the disparate organizations to foster cooperative relationships. Bridge-building proved a mutually beneficial exercise. Variance in organizational strategies and the timing of different reform efforts limited, but did not eliminate, opportunities for collaboration. Coalitions formed when groups came together temporarily, and then drifted apart when a reform effort reached its terminus, leaving future collaboration still possible.
ContributorsTompkins, Adam (Author) / Hirt, Paul (Thesis advisor) / Rome, Adam (Committee member) / Adamson, Joni (Committee member) / Rosales, F (Committee member) / Arizona State University (Publisher)
Created2011
Description
Pro-environmental goals often pit immediate self-interest against future communal interest. Consequently, the motivation to behave in pro-environmental ways can be particularly difficult to maintain over time. By framing environmental ills as threats to one's chronic concerns, I suggest that chronic motivations, such as disease avoidance, can be leveraged to engender longer-lasting pro-environmental motivation. Specifically, I suggest that three distinct categories of environmental ills should be associated with distinct chronic concerns, and that the mechanisms that regulate these concerns should also regulate reactions to related environmental ills: pollution should engage a pathogenic disgust mechanism, wastefulness a moral disgust mechanism, and framing environmental outcomes as posing safety concerns should be linked to fear and anger mechanisms. Results of four experiments did not lend consistent support to the hypotheses. Neither situationally primed concerns nor motivation-relevant individual differences produced consistent results suggesting an association between the proposed motivations and the relevant environmental outcomes.
ContributorsBerlin, Joy (Author) / Neuberg, Steven L. (Thesis advisor) / Kenrick, Douglas T. (Committee member) / Ledlow, Susan E (Committee member) / Shiota, Michelle N. (Committee member) / Arizona State University (Publisher)
Created2012
Description
I present the results of studies from two historically separate fields of research: heat related illness and human thermal comfort adaptation. My research objectives were: (a) to analyze the relationships between climate and heat related morbidity in Phoenix, Arizona and Chicago, Illinois; (b) explore possible linkages of human thermal comfort adaptation to heat-related illness; and (c) show possible benefits of collaboration between the two fields of research. Previous climate and mortality studies discovered regional patterns in summertime mortality in North America: lower in hot, southern cities compared to more temperate cities. I examined heat related emergency (911) dispatches from these two geographically and climatically different cities. I analyzed with local weather conditions with 911 dispatches identified by responders as "heat" related from 2001 to 2006 in Phoenix and 2003 through 2006 in Chicago. Both cities experienced a rapid rise in heat-related dispatches with increasing temperature and heat index, but at higher thresholds in Phoenix. Overall, Phoenix had almost two and half times more heat-related dispatches than Chicago. However, Phoenix did not experience the large spikes of heat-related dispatches that occurred in Chicago. These findings suggest a resilience to heat-related illness that may be linked to acclimatization in Phoenix. I also present results from a survey based outdoor human thermal comfort field study in Phoenix to assess levels of local acclimatization. Previous research in outdoor human thermal comfort in hot humid and temperate climates used similar survey-based methodologies and found higher levels of thermal comfort (adaptation to heat) that in warmer climates than in cooler climates. The study presented in this dissertation found outdoor thermal comfort thresholds and heat tolerance levels in Phoenix were higher than previous studies from temperate climates more similar to Chicago. These differences were then compared to the differences in weather conditions associated with heat-related dispatches. The higher comfort thresholds in Phoenix were similar in scale to the climate differences associated with the upsurge in heat-related dispatches in Phoenix and Chicago. This suggests a link between heat related illness and acclimatization, and illustrates potential for collaboration in research between the two fields.
ContributorsHartz, Donna (Author) / Brazel, Anthony J. (Thesis advisor) / Heisler, Gordon (Committee member) / Cerveny, Randal (Committee member) / Arizona State University (Publisher)
Created2012
Description
Food deserts are the collection of deprived food environments and limit local residents from accessing healthy and affordable food. This dissertation research in San Lorenzo, Paraguay tests if the assumptions about food deserts in the Global North are also relevant to the Global South. In the Global South, the recent growth of supermarkets is transforming local food environments and may worsen residential food access, such as through emerging more food deserts globally. This dissertation research blends the tools, theories, and frameworks from clinical nutrition, public health, and anthropology to identify the form and impact of food deserts in the market city of San Lorenzo, Paraguay. The downtown food retail district and the neighborhood food environment in San Lorenzo were mapped to assess what stores and markets are used by residents. The food stores include a variety of formal (supermarkets) and informal (local corner stores and market vendors) market sources. Food stores were characterized using an adapted version of the Nutrition Environment Measures Survey for Stores (NEMS-S) to measure store food availability, affordability, and quality. A major goal in this dissertation was to identify how and why residents select a type of food store source over another using various ethnographic interviewing techniques. Residential store selection was linked to the NEMS-S measures to establish a connection between the objective quality of the local food environment, residential behaviors in the local food environment, and nutritional health status. Using a sample of 68 households in one neighborhood, modeling suggested the quality of local food environment does effect weight (measure as body mass index), especially for those who have lived longer in poorer food environments. More generally, I find that San Lorenzo is a city-wide food desert, suggesting that research needs to establish more nuanced categories of poor food environments to address how food environments emerge health concerns in the Global South.
ContributorsGartin, Meredith (Author) / Brewis Slade, Alexandra (Thesis advisor) / Boone, Christopher (Committee member) / Wutich, Amber (Committee member) / Arizona State University (Publisher)
Created2012
Description
This dissertation focuses on the application of urban metabolism metrology (UMM) to process streams of the natural and built water environment to gauge public health concerning exposure to carcinogenic N-nitrosamines and abuse of narcotics. A survey of sources of exposure to N-nitrosamines in the U.S. population identified contaminated food products (1,900 ± 380 ng/day) as important drivers of attributable cancer risk (Chapter 2). Freshwater sediments in the proximity of U.S. municipal wastewater treatment plants were shown for the first time to harbor carcinogenic N-nitrosamine congeners, including N-nitrosodibutylamine (0.2-3.3 ng/g dw), N-nitrosodiphenylamine (0.2-4.7 ng/g dw), and N-nitrosopyrrolidine (3.4-19.6 ng/g dw) were, with treated wastewater discharge representing one potential factor contributing to the observed contamination (p=0.42) (Chapter 3). Opioid abuse rates in two small midwestern communities were estimated through the application of wastewater-based epidemiology (WBE). Average concentrations of opioids (City 1; City 2) were highest for morphine (713 ± 38, 306 ± 29 ng/L) and varied by for the remainder of the screened analytes. Furthermore, concentrations of the powerful opioid fentanyl (1.7 ± 0.2, 1.0 ± 0.5 ng/L) in wastewater were reported for the first time in the literature for the U.S. (Chapter 4). To gauge narcotic consumption within college-aged adults the WBE process used in Chapter 4 was applied to wastewater collected from a large university in the Southwestern U.S. Estimated narcotics consumption, in units of mg/day/1,000 persons showed the following rank order: cocaine (470 ± 42), heroin (474 ± 32), amphetamine (302 ± 14) and methylphenidate (236 ± 28). Most parental drugs and their respective metabolites showed detection frequencies in campus wastewater of 80% or more, with the notable exception of fentanyl, norfentanyl, buprenorphine, and norbuprenorphine. Estimated consumption of all narcotics, aside from attention-deficit/hyperactivity disorder medication, were higher than values reported in previous U.S. WBE studies for U.S. campuses (Chapter 5). The analyses presented here have identified variation in narcotic consumption habits across different U.S. communities, which can be gauged through UMM. Application of these techniques should be implemented throughout U.S. communities to provide insight into ongoing substance abuse and health issues within a community.
ContributorsGushgari, Adam Jon (Author) / Halden, Rolf U. (Thesis advisor) / Kavazanjian, Edward (Committee member) / Fraser, Matthew (Committee member) / Venkatesan, Arjun (Committee member) / Mascaro, Giuseppe (Committee member) / Arizona State University (Publisher)
Created2018
Description
Avian influenzas are zoonoses, or pathogens borne by wildlife and livestock that
can also infect people. In recent decades, and especially since the emergence of highly pathogenic avian influenza (HPAI) H5N1 in 1996, these diseases have become a significant threat to animal and public health across the world. HPAI H5N1 has caused severe damage to poultry populations, killing, or prompting the culling of, millions of birds in Asia, Africa, and Europe. It has also infected hundreds of people, with a mortality rate of approximately 50%. This dissertation focuses on the ecological and socioeconomic drivers of avian influenza risk, particularly in China, the most populous country to be infected. Among the most significant ecological risk factors are landscapes that serve as “mixing zones” for wild waterfowl and poultry, such as rice paddy, and nearby lakes and wetlands that are important breeding and wintering habitats for wild birds. Poultry outbreaks often involve cross infections between wild and domesticated birds. At the international level, trade in live poultry can spread the disease, especially if the imports are from countries not party to trade agreements with well-developed biosecurity standards. However, these risks can be mitigated in a number of ways. Protected habitats, such as Ramsar wetlands, can segregate wild bird and poultry populations, thereby lowering the chance of interspecies transmission. The industrialization of poultry production, while not without ethical and public health problems, can also be risk-reducing by causing wild-domestic segregation and allowing for the more efficient application of surveillance, vaccination, and other biosecurity measures. Disease surveillance is effective at preventing the spread of avian influenza, including across international borders. Economic modernization in general, as reflected in rising per-capita GDP, appears to mitigate avian influenza risks at both the national and sub-national levels. Poultry vaccination has been effective in many cases, but is an incomplete solution because of the practical difficulties of sustained and widespread implementation. The other popular approach to avian influenza control is culling, which can be highly expensive and raise ethical concerns about large-scale animal slaughter. Therefore, it is more economically efficient, and may even be more ethical, to target the socio-ecological drivers of avian influenza risks, including by implementing the policies discussed here.
can also infect people. In recent decades, and especially since the emergence of highly pathogenic avian influenza (HPAI) H5N1 in 1996, these diseases have become a significant threat to animal and public health across the world. HPAI H5N1 has caused severe damage to poultry populations, killing, or prompting the culling of, millions of birds in Asia, Africa, and Europe. It has also infected hundreds of people, with a mortality rate of approximately 50%. This dissertation focuses on the ecological and socioeconomic drivers of avian influenza risk, particularly in China, the most populous country to be infected. Among the most significant ecological risk factors are landscapes that serve as “mixing zones” for wild waterfowl and poultry, such as rice paddy, and nearby lakes and wetlands that are important breeding and wintering habitats for wild birds. Poultry outbreaks often involve cross infections between wild and domesticated birds. At the international level, trade in live poultry can spread the disease, especially if the imports are from countries not party to trade agreements with well-developed biosecurity standards. However, these risks can be mitigated in a number of ways. Protected habitats, such as Ramsar wetlands, can segregate wild bird and poultry populations, thereby lowering the chance of interspecies transmission. The industrialization of poultry production, while not without ethical and public health problems, can also be risk-reducing by causing wild-domestic segregation and allowing for the more efficient application of surveillance, vaccination, and other biosecurity measures. Disease surveillance is effective at preventing the spread of avian influenza, including across international borders. Economic modernization in general, as reflected in rising per-capita GDP, appears to mitigate avian influenza risks at both the national and sub-national levels. Poultry vaccination has been effective in many cases, but is an incomplete solution because of the practical difficulties of sustained and widespread implementation. The other popular approach to avian influenza control is culling, which can be highly expensive and raise ethical concerns about large-scale animal slaughter. Therefore, it is more economically efficient, and may even be more ethical, to target the socio-ecological drivers of avian influenza risks, including by implementing the policies discussed here.
ContributorsWu, Tong (Author) / Perrings, Charles (Thesis advisor) / Collins, Jim (Committee member) / Daszak, Peter (Committee member) / Minteer, Ben (Committee member) / Kinzig, Ann (Committee member) / Arizona State University (Publisher)
Created2018
Description
Monitoring human exposure to chemicals posing public health threats is critically important for risk management and for informing regulatory actions. Chemical threats result from both environmental pollutants and elected substance use (e.g., consumption of drugs, alcohol and tobacco). Measuring chemical occurrence and concentrations in environmental matrices can help to pinpoint human exposure routes. For instance, indoor dust, a sink of indoor environmental contaminants, can serve to assess indoor air contamination and associated human exposures. Urban wastewater arriving at treatment plants contains urine and stool from the general population, the analysis of which can provide information on chemical threats in the community and ongoing harmful exposures. Analysis of sewage sludge can serve to reveal the identity and quantity of persistent organic pollutants in cities and inform estimates of toxic body burdens in local populations.
The objective of this dissertation was to investigate the occurrence and quantity of select, potentially harmful, anthropogenic chemicals in various environmental matrices and to explore the diagnostic value of analytical assays for informing public health decision-making. This dissertation (i) is the first to report spatio-temporal variations and estrogenic burdens of five parabens in sewage sludge from at the U.S. nationwide scale; (ii) represents the first China-wide survey to assess the occurrence and toxic emissions of parabens, triclosan, triclocarban, as well as triclocarban metabolites and transformation products contained in Chinese sewage sludge; (iii) documents the first use of a dispersive solid phase extraction method for indoor dust to measure dust-borne parabens, triclosan and triclocarban and estimating associated human exposures from dust ingestion; and (iv) is the first U.S. study to assess population-level alcohol and nicotine consumption in three U.S. communities using wastewater-based epidemiology (WBE). Obtained data on baseline levels of selected emerging contaminants in sewage sludge and indoor dust can serve to inform the future monitoring needs, risk assessment, and policy making. This work showcases the utility of WBE and urban metabolism metrology via dust and sewage sludge analysis to assess human behavior (e.g., drinking and smoking) and exposure risks more rapidly, efficiently and anonymously than traditional approaches can.
The objective of this dissertation was to investigate the occurrence and quantity of select, potentially harmful, anthropogenic chemicals in various environmental matrices and to explore the diagnostic value of analytical assays for informing public health decision-making. This dissertation (i) is the first to report spatio-temporal variations and estrogenic burdens of five parabens in sewage sludge from at the U.S. nationwide scale; (ii) represents the first China-wide survey to assess the occurrence and toxic emissions of parabens, triclosan, triclocarban, as well as triclocarban metabolites and transformation products contained in Chinese sewage sludge; (iii) documents the first use of a dispersive solid phase extraction method for indoor dust to measure dust-borne parabens, triclosan and triclocarban and estimating associated human exposures from dust ingestion; and (iv) is the first U.S. study to assess population-level alcohol and nicotine consumption in three U.S. communities using wastewater-based epidemiology (WBE). Obtained data on baseline levels of selected emerging contaminants in sewage sludge and indoor dust can serve to inform the future monitoring needs, risk assessment, and policy making. This work showcases the utility of WBE and urban metabolism metrology via dust and sewage sludge analysis to assess human behavior (e.g., drinking and smoking) and exposure risks more rapidly, efficiently and anonymously than traditional approaches can.
ContributorsChen, Jing (Author) / Halden, Rolf U. (Thesis advisor) / Borges, Chad R (Committee member) / Abbaszadegan, Morteza (Committee member) / Arizona State University (Publisher)
Created2018
Description
This research investigates the biophysical and institutional mechanisms affecting the distribution of metals in the Sonoran Desert of Arizona. To date, a long-term, interdisciplinary perspective on metal pollution in the region has been lacking. To address this gap, I integrated approaches from environmental chemistry, historical geography, and institutional economics to study the history of metal pollution in the desert. First, by analyzing the chemistry embodied in the sequentially-grown spines of long-lived cacti, I created a record of metal pollution that details biogeochemical trends in the desert since the 1980s. These data suggest that metal pollution is not simply a legacy of early industrialization. Instead, I found evidence of recent metal pollution in both the heart of the city and a remote, rural location. To understand how changing land uses may have contributed to this, I next explored the historical geography of industrialization in the desert. After identifying cities and mining districts as hot spots for airborne metals, I used a mixture of historical reports, maps, and memoirs to reconstruct the industrial history of these polluted landscapes. In the process, I identified three key transitions in the energy-metal nexus that drove the redistribution of metals from mineral deposits to urban communities. These transitions coincided with the Columbian exchange, the arrival of the railroads, and the economic restructuring that accompanied World War II. Finally, to determine how legal and political forces may be influencing the fate of metals, I studied the evolution of the rights and duties affecting metals in their various forms. This allowed me to track changes in the institutions regulating metals from the mining laws of the 19th century through their treatment as occupational and public health hazards in the 20th century. In the process, I show how Arizona’s environmental and resource institutions were often transformed by extra-territorial concerns. Ultimately, this created an institutional system that compartmentalizes metals and fails to appreciate their capacity to mobilize across legal and biophysical boundaries to accumulate in the environment. Long-term, interdisciplinary perspectives such as this are critical for untangling the complex web of elements and social relations transforming the modern world.
ContributorsHester, Cyrus M (Author) / Larson, Kelli L (Thesis advisor) / Laubichler, Manfred D (Thesis advisor) / MacFadyen, Joshua (Committee member) / Arizona State University (Publisher)
Created2019