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Electrical neural activity detection and tracking have many applications in medical research and brain computer interface technologies. In this thesis, we focus on the development of advanced signal processing algorithms to track neural activity and on the mapping of these algorithms onto hardware to enable real-time tracking. At the heart

Electrical neural activity detection and tracking have many applications in medical research and brain computer interface technologies. In this thesis, we focus on the development of advanced signal processing algorithms to track neural activity and on the mapping of these algorithms onto hardware to enable real-time tracking. At the heart of these algorithms is particle filtering (PF), a sequential Monte Carlo technique used to estimate the unknown parameters of dynamic systems. First, we analyze the bottlenecks in existing PF algorithms, and we propose a new parallel PF (PPF) algorithm based on the independent Metropolis-Hastings (IMH) algorithm. We show that the proposed PPF-IMH algorithm improves the root mean-squared error (RMSE) estimation performance, and we demonstrate that a parallel implementation of the algorithm results in significant reduction in inter-processor communication. We apply our implementation on a Xilinx Virtex-5 field programmable gate array (FPGA) platform to demonstrate that, for a one-dimensional problem, the PPF-IMH architecture with four processing elements and 1,000 particles can process input samples at 170 kHz by using less than 5% FPGA resources. We also apply the proposed PPF-IMH to waveform-agile sensing to achieve real-time tracking of dynamic targets with high RMSE tracking performance. We next integrate the PPF-IMH algorithm to track the dynamic parameters in neural sensing when the number of neural dipole sources is known. We analyze the computational complexity of a PF based method and propose the use of multiple particle filtering (MPF) to reduce the complexity. We demonstrate the improved performance of MPF using numerical simulations with both synthetic and real data. We also propose an FPGA implementation of the MPF algorithm and show that the implementation supports real-time tracking. For the more realistic scenario of automatically estimating an unknown number of time-varying neural dipole sources, we propose a new approach based on the probability hypothesis density filtering (PHDF) algorithm. The PHDF is implemented using particle filtering (PF-PHDF), and it is applied in a closed-loop to first estimate the number of dipole sources and then their corresponding amplitude, location and orientation parameters. We demonstrate the improved tracking performance of the proposed PF-PHDF algorithm and map it onto a Xilinx Virtex-5 FPGA platform to show its real-time implementation potential. Finally, we propose the use of sensor scheduling and compressive sensing techniques to reduce the number of active sensors, and thus overall power consumption, of electroencephalography (EEG) systems. We propose an efficient sensor scheduling algorithm which adaptively configures EEG sensors at each measurement time interval to reduce the number of sensors needed for accurate tracking. We combine the sensor scheduling method with PF-PHDF and implement the system on an FPGA platform to achieve real-time tracking. We also investigate the sparsity of EEG signals and integrate compressive sensing with PF to estimate neural activity. Simulation results show that both sensor scheduling and compressive sensing based methods achieve comparable tracking performance with significantly reduced number of sensors.
ContributorsMiao, Lifeng (Author) / Chakrabarti, Chaitali (Thesis advisor) / Papandreou-Suppappola, Antonia (Thesis advisor) / Zhang, Junshan (Committee member) / Bliss, Daniel (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2013
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Description
This dissertation introduces stochastic ordering of instantaneous channel powers of fading channels as a general method to compare the performance of a communication system over two different channels, even when a closed-form expression for the metric may not be available. Such a comparison is with respect to a variety of

This dissertation introduces stochastic ordering of instantaneous channel powers of fading channels as a general method to compare the performance of a communication system over two different channels, even when a closed-form expression for the metric may not be available. Such a comparison is with respect to a variety of performance metrics such as error rates, outage probability and ergodic capacity, which share common mathematical properties such as monotonicity, convexity or complete monotonicity. Complete monotonicity of a metric, such as the symbol error rate, in conjunction with the stochastic Laplace transform order between two fading channels implies the ordering of the two channels with respect to the metric. While it has been established previously that certain modulation schemes have convex symbol error rates, there is no study of the complete monotonicity of the same, which helps in establishing stronger channel ordering results. Toward this goal, the current research proves for the first time, that all 1-dimensional and 2-dimensional modulations have completely monotone symbol error rates. Furthermore, it is shown that the frequently used parametric fading distributions for modeling line of sight exhibit a monotonicity in the line of sight parameter with respect to the Laplace transform order. While the Laplace transform order can also be used to order fading distributions based on the ergodic capacity, there exist several distributions which are not Laplace transform ordered, although they have ordered ergodic capacities. To address this gap, a new stochastic order called the ergodic capacity order has been proposed herein, which can be used to compare channels based on the ergodic capacity. Using stochastic orders, average performance of systems involving multiple random variables are compared over two different channels. These systems include diversity combining schemes, relay networks, and signal detection over fading channels with non-Gaussian additive noise. This research also addresses the problem of unifying fading distributions. This unification is based on infinite divisibility, which subsumes almost all known fading distributions, and provides simplified expressions for performance metrics, in addition to enabling stochastic ordering.
ContributorsRajan, Adithya (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Bliss, Daniel (Committee member) / Kosut, Oliver (Committee member) / Arizona State University (Publisher)
Created2014
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Description
In recent years, there has been an increased interest in sharing available bandwidth to avoid spectrum congestion. With an ever-increasing number wireless users, it is critical to develop signal processing based spectrum sharing algorithms to achieve cooperative use of the allocated spectrum among multiple systems in order to reduce

In recent years, there has been an increased interest in sharing available bandwidth to avoid spectrum congestion. With an ever-increasing number wireless users, it is critical to develop signal processing based spectrum sharing algorithms to achieve cooperative use of the allocated spectrum among multiple systems in order to reduce interference between systems. This work studies the radar and communications systems coexistence problem using two main approaches. The first approach develops methodologies to increase radar target tracking performance under low signal-to-interference-plus-noise ratio (SINR) conditions due to the coexistence of strong communications interference. The second approach jointly optimizes the performance of both systems by co-designing a common transmit waveform.

When concentrating on improving radar tracking performance, a pulsed radar that is tracking a single target coexisting with high powered communications interference is considered. Although the Cramer-Rao lower bound (CRLB) on the covariance of an unbiased estimator of deterministic parameters provides a bound on the estimation mean squared error (MSE), there exists an SINR threshold at which estimator covariance rapidly deviates from the CRLB. After demonstrating that different radar waveforms experience different estimation SINR thresholds using the Barankin bound (BB), a new radar waveform design method is proposed based on predicting the waveform-dependent BB SINR threshold under low SINR operating conditions.

A novel method of predicting the SINR threshold value for maximum likelihood estimation (MLE) is proposed. A relationship is shown to exist between the formulation of the BB kernel and the probability of selecting sidelobes for the MLE. This relationship is demonstrated as an accurate means of threshold prediction for the radar target parameter estimation of frequency, time-delay and angle-of-arrival.



For the co-design radar and communications system problem, the use of a common transmit waveform for a pulse-Doppler radar and a multiuser communications system is proposed. The signaling scheme for each system is selected from a class of waveforms with nonlinear phase function by optimizing the waveform parameters to minimize interference between the two systems and interference among communications users. Using multi-objective optimization, a trade-off in system performance is demonstrated when selecting waveforms that minimize both system interference and tracking MSE.
ContributorsKota, John S (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Berisha, Visar (Committee member) / Bliss, Daniel (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2016
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Description
Biological and biomedical measurements, when adequately analyzed and processed, can be used to impart quantitative diagnosis during primary health care consultation to improve patient adherence to recommended treatments. For example, analyzing neural recordings from neurostimulators implanted in patients with neurological disorders can be used by a physician to adjust detrimental

Biological and biomedical measurements, when adequately analyzed and processed, can be used to impart quantitative diagnosis during primary health care consultation to improve patient adherence to recommended treatments. For example, analyzing neural recordings from neurostimulators implanted in patients with neurological disorders can be used by a physician to adjust detrimental stimulation parameters to improve treatment. As another example, biosequences, such as sequences from peptide microarrays obtained from a biological sample, can potentially provide pre-symptomatic diagnosis for infectious diseases when processed to associate antibodies to specific pathogens or infectious agents. This work proposes advanced statistical signal processing and machine learning methodologies to assess neurostimulation from neural recordings and to extract diagnostic information from biosequences.

For locating specific cognitive and behavioral information in different regions of the brain, neural recordings are processed using sequential Bayesian filtering methods to detect and estimate both the number of neural sources and their corresponding parameters. Time-frequency based feature selection algorithms are combined with adaptive machine learning approaches to suppress physiological and non-physiological artifacts present in neural recordings. Adaptive processing and unsupervised clustering methods applied to neural recordings are also used to suppress neurostimulation artifacts and classify between various behavior tasks to assess the level of neurostimulation in patients.

For pathogen detection and identification, random peptide sequences and their properties are first uniquely mapped to highly-localized signals and their corresponding parameters in the time-frequency plane. Time-frequency signal processing methods are then applied to estimate antigenic determinants or epitope candidates for detecting and identifying potential pathogens.
ContributorsMaurer, Alexander Joseph (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Chakrabarti, Chaitali (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2016
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Description
Full-duplex communication has attracted significant attention as it promises to increase the spectral efficiency compared to half-duplex. Multi-hop full-duplex networks add new dimensions and capabilities to cooperative networks by facilitating simultaneous transmission and reception and improving data rates.

When a relay in a multi-hop full-duplex system amplifies and forwards its received

Full-duplex communication has attracted significant attention as it promises to increase the spectral efficiency compared to half-duplex. Multi-hop full-duplex networks add new dimensions and capabilities to cooperative networks by facilitating simultaneous transmission and reception and improving data rates.

When a relay in a multi-hop full-duplex system amplifies and forwards its received signals, due to the presence of self-interference, the input-output relationship is determined by recursive equations. This thesis introduces a signal flow graph approach to solve the problem of finding the input-output relationship of a multi-hop amplify-and-forward full-duplex relaying system using Mason's gain formula. Even when all links have flat fading channels, the residual self-interference component due to imperfect self-interference cancellation at the relays results in an end-to-end effective channel that is an all-pole frequency-selective channel. Also, by assuming the relay channels undergo frequency-selective fading, the outage probability analysis is performed and the performance is compared with the case when the relay channels undergo frequency-flat fading. The outage performance of this system is performed assuming that the destination employs an equalizer or a matched filter.

For the case of a two-hop (single relay) full-duplex amplify-and-forward relaying system, the bounds on the outage probability are derived by assuming that the destination employs a matched filter or a minimum mean squared error decision feedback equalizer. For the case of a three-hop (two-relay) system with frequency-flat relay channels, the outage probability analysis is performed by considering the output SNR of different types of equalizers and matched filter at the destination. Also, the closed-form upper bounds on the output SNR are derived when the destination employs a minimum mean squared error decision feedback equalizer which is used in outage probability analysis. It is seen that for sufficiently high target rates, full-duplex relaying with equalizers is always better than half-duplex relaying in terms of achieving lower outage probability, despite the higher RSI. In contrast, since full-duplex relaying with MF is sensitive to RSI, it is outperformed by half-duplex relaying under strong RSI.
ContributorsSureshbabu, Abhilash (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Bliss, Daniel (Committee member) / Arizona State University (Publisher)
Created2016