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Creating Sustainability at ASU: Closing the Gap Between Concept and Application

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This thesis is exploring the potential disconnect between the operational and cultural parts in the making of sustainability at Arizona State University (ASU) to find the disconnect in operational goals, student engagement, and thus student behavior in building sustainability at

This thesis is exploring the potential disconnect between the operational and cultural parts in the making of sustainability at Arizona State University (ASU) to find the disconnect in operational goals, student engagement, and thus student behavior in building sustainability at the university. To do so, I compare and contrast how ASU, Northern Arizona University (NAU), and the University of Arizona (UA) define, create, and demonstrate sustainability in their university’s culture and campus engagement programs. I first define what “culture” is in this study to provide context on how the word is being applied. Next, I assess how culture is reflected in the mission, vision, and/or goals of each university to set the tone for how the university intends to shape the culture of student experience through its services, as well as provide context where sustainability concepts may fit within. Then I assess what sustainability is demonstrated and defined as at each university. To thread each of these components together, I compare and contrast campus sustainability engagement programs at ASU, NAU, and UA based on the Sustainability Tracking, Assessment and Rating System (STARS) reports produced by The Association for the Advancement of Sustainability in Higher Education’s (AASHE), as engagement programs are a reflection of the university’s vision, goals, and values brought from theory to practice. My findings are demonstrated in the form of a policy analysis, followed by recommendations on closing the gap where engagement programs and opportunities are potentially missing. These recommendations are intended to advance a stronger culture of sustainability on campus at ASU.

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2020-05

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Effect of Rexinoids on Inducing Effector T Cell Chemotaxis

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The retinoid-X receptor (RXR) can form heterodimers with both the retinoic-acid
receptor (RAR) and vitamin D receptor (VDR). The RXR/RAR dimer is activated by ligand all
trans retinoic acid (ATRA), which culminates in gut-specific effector T cell migration. Similarly,

The retinoid-X receptor (RXR) can form heterodimers with both the retinoic-acid
receptor (RAR) and vitamin D receptor (VDR). The RXR/RAR dimer is activated by ligand all
trans retinoic acid (ATRA), which culminates in gut-specific effector T cell migration. Similarly,
the VDR/RXR dimer binds 1,25(OH)2D3 to cause skin-specific effector T cell migration.
Targeted migration is a potent addition to current vaccines, as it would induce activated T cell
trafficking to appropriate areas of the immune system and ensure optimal stimulation (40).
ATRA, while in use clinically, is limited by toxicity and chemical instability. Rexinoids
are stable, synthetically developed ligands specific for the RXR. We have previously shown that
select rexinoids can enhance upregulation of gut tropic CCR9 receptors on effector T cells.
However, it is important to establish whether these cells can actually migrate, to show the
potential of rexinoids as vaccine adjuvants that can cause gut specific T cell migration.
Additionally, since the RXR is a major contributor to VDR-mediated transcription and
epidermotropism (15), it is worth investigating whether these compounds can also function as
adjuvants that promote migration by increasing expression of skin tropic CCR10 receptors on T
cells.
Prior experiments have demonstrated that select rexinoids can induce gut tropic migration
of CD8+ T cells in an in vitro assay and are comparable in effectiveness to ATRA (7). The effect
of rexinoids on CD4+ T cells is unknown however, so the aim of this project was to determine if
rexinoids can cause gut tropic migration in CD4+ T cells to a similar extent. A secondary aim
was to investigate whether varying concentrations in 1,25-Dihydroxyvitamin D3 can be linked to
increasing CCR10 upregulation on Jurkat CD4+ T cells, with the future aim to combine 1,25
Dihydroxyvitamin D3 with rexinoids.
These hypotheses were tested using murine splenocytes for the migration experiment, and
human Jurkat CD4+ T cells for the vitamin D experiment. Migration was assessed using a
Transwell chemotaxis assay. Our findings support the potential of rexinoids as compounds
capable of causing gut-tropic migration in murine CD4+ T cells in vitro, like ATRA. We did not
observe conclusive evidence that vitamin D3 causes upregulated CCR10 expression, but this
experiment must be repeated with a human primary T cell line.

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2020-05

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Affordable and Environmentally Conscious Living: Residential Rooftop Solar Solutions for Low-Income and Middle-Income Families

Description

As climate change and air pollution continue to plague the world today, committed citizens are doing their part to minimize their environmental impact. However, financial limitations have hindered a majority of individuals from adopting clean, renewable energy such as roofto

As climate change and air pollution continue to plague the world today, committed citizens are doing their part to minimize their environmental impact. However, financial limitations have hindered a majority of individuals from adopting clean, renewable energy such as rooftop photovoltaic solar systems. England Sustainability Consulting plans to reverse this limitation and increase affordability for residents across Northern California to install solar panel systems for their energy needs. The purpose of this proposal is to showcase a new approach to procuring solar panel system components while offering the same products needed by each customer. We will examine market data to further prove the feasibility of this business approach while remaining profitable and spread our company's vision across all of Northern California.

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2018-05

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Process Improvement and Sustainability: Restructuring the Leadership Scholarship Program Cohort Selection

Description

Although the Leadership Scholarship Program has seen successful recruiting processes throughout changes in leadership of the program; the organization expressed a need for major overhaul to reevaluate the decisions of the process and to establish backing for those decisions. By

Although the Leadership Scholarship Program has seen successful recruiting processes throughout changes in leadership of the program; the organization expressed a need for major overhaul to reevaluate the decisions of the process and to establish backing for those decisions. By asking current and alumni members of the program about what they would like to see in a future member of the program as well as which parts of the process they found most important, the qualities of a future member of the program could be established and weighted. The goals of the reevaluation were to help eliminate bias, discrepancies between applications with extremely different uncontrollable factors, define points of discrepancies, and establish organizational sustainability while achieving a 100% acceptance rate from offered students. Each of these goals was achieved through methods outlined in the LSP Selection Process Manual that was written as a result of this reevaluation. The manual also outlines ways to improve the process going forward.

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2018-05

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Theorizing the 21st Century City: Urban Design through the SETS Framework

Description

As the move towards sustainable urbanism grows, understanding how the city has previously been envisioned and designed will be useful to moving forward. This work examines the legacy of urban design theories, what these theories have implied about what the

As the move towards sustainable urbanism grows, understanding how the city has previously been envisioned and designed will be useful to moving forward. This work examines the legacy of urban design theories, what these theories have implied about what the city should be, and their sustainability consequences. Noticing three prominent urban design visions of the city, the technological city (as proposed in 1922 by Le Corbusier's Ville contemporaine and later in 1933 by his Ville Radieuse (The Radiant City), and in 1935 by Frank Lloyd Wright's' Broadacre City), the social city (as explored in 1961 by Jane Jacobs and in 1976 by Edward Relph of the University of Chicago), and the ecological city (as expounded upon in 1924 by both Lewis Mumford and in 1969 by Ian McHarg), I have newly applied the social-ecological-technical systems framework (SETS) to help classify and analyze these urban design theories and how they have mixed to create hybrid perspectives in more recent urban design theory. Lastly, I have proposed an urban design theory that envisions the sustainable city as an ongoing process. Hopefully, this vision that will hopefully be useful to the future of sustainable development in cities, as will a more organized understanding of urban design theories and their sustainability outcomes.

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2018-05

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Honey Bee Nutrition and Colony Collapse Disorder: How legislation can curtail bee population decline

Description

The purpose of this experiment was to test how different nutrition supplementation would affect honey bee lifespan. The use of sugar syrup and pollen as well as protein, probiotic, and vitamin supplement were the independent variables in this experiment. The

The purpose of this experiment was to test how different nutrition supplementation would affect honey bee lifespan. The use of sugar syrup and pollen as well as protein, probiotic, and vitamin supplement were the independent variables in this experiment. The average lifespan of a honey bee (Apis mellifera) is around 30 days depending on climate and time of year (Amdam & Omholt, 2002). This experiment yielded results that would require further testing but was able to conclude that a diet of sugar syrup is not sufficient for honey bees, whereas pollen and probiotic supplement showed positive effects on average lifespan. Protein supplement showed no statistically significant advantage or disadvantage to pollen when it comes to short term supplementation. Considering the importance of nutrition on honey bee lifespan, this paper also explores specific ways legislation can aid in pollinator population decline, considering the impacts of colonies without access to a healthy diet.

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2018-05

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Future H2O: Front-end Design Experience

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As we already know, fresh water is essential to human life as it sustains and replenishes our bodies. Water sustainability is clearly an important issue that need to be addressed in our world of growing demand and shrinking resources. The

As we already know, fresh water is essential to human life as it sustains and replenishes our bodies. Water sustainability is clearly an important issue that need to be addressed in our world of growing demand and shrinking resources. The ASU Future H2O program seeks to make a difference in the development of water sustainability programs by performing experiments that convert urine into reusable water. The goal is to make reusable water processes become inexpensive and easily accessible to local businesses. This promises a significant environmental impact. In order to make the process of development more efficient we can combine engineering technology with scientific experimentation. As an engineering student and an advocate of water sustainability, I have a chance to design the front-end platform that will use IoT to make the experimental process more accessible and effective. In this paper, I will document the entire process involved in the designing process and what I have learned.

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2018-05

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Menopause Symptoms in Underserved and Homeless Women living in the Extreme Temperatures of Arizona

Description

Regional and geographical differences may explain variability in menopausal symptom occurrence due to development of climate-specific thermoneutral zones leading to population-specific hot flash frequencies. Limited information available regarding menopausal symptoms in underserved women living in extreme heat.

Understanding the perception of

Regional and geographical differences may explain variability in menopausal symptom occurrence due to development of climate-specific thermoneutral zones leading to population-specific hot flash frequencies. Limited information available regarding menopausal symptoms in underserved women living in extreme heat.

Understanding the perception of menopausal symptoms in underserved women living in extreme heat regions to identify if heat impacts perception of menopausal symptoms was the objective of this study. Women in free, low-income, and homeless clinics in Phoenix were surveyed during summer and winter months using a self-administered, written questionnaire including demographic, climate and menopause related questions, including the Green Climacteric Scale (GCS).

A total of 139 predominantly Hispanic (56 %), uninsured (53 %), menopausal (56 %), mid-aged (mean 49.9, SD 10.3) women were surveyed— 36% were homeless or in shelters. Most women were not on menopausal hormone therapy (98 %). Twenty-two percent reported hot flashes and 26% night sweats. Twenty-five percent of women reported previously becoming ill from heat. More women thought season influenced menopausal symptoms during summer than winter (41 % vs. 14 %, p = 0.0009). However, majority of women did not think temperature outside influenced their menopausal symptoms and that did not differ by season (73 % in winter vs. 60% in summer, p=0.1094). No statistically significant differences seen for vasomotor symptoms between winter and summer months.

Regional and geographical differences may be key in understanding the variability in menopausal symptoms. Regardless of season, the menopausal, underserved and homeless women living in Arizona reported few vasomotor symptoms. In the summer, they were more likely to report that the season influenced their menopausal symptoms rather than temperature suggesting an influence of the season on symptom perception.

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2018-05

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New Diagnostic Methods for Detecting Microvillus Inclusion Disease

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Microvillus Inclusion disease is a fatal disease found in the Navajo population caused by a single nucleotide polymorphism. It is characterized by intractable diarrhea and is often fatal early in life.1 The current method of diagnosis is sending duodenal biopsies

Microvillus Inclusion disease is a fatal disease found in the Navajo population caused by a single nucleotide polymorphism. It is characterized by intractable diarrhea and is often fatal early in life.1 The current method of diagnosis is sending duodenal biopsies for histopathological examination and confirmatory testing through genomic sequencing. The purpose of this experiment was to create a more simple and cost-effective diagnostic method for detecting Microvillus Inclusion disease. Three methods were explored (RFLP2, ARMS3,4, and Tentacle Probes5,6) and two methods were tested to determine their ability and their efficiency in detecting the SNP that causes the disease.2 Tests using the RFLP2 method and synthetic DNA resulted in 9% false-positive rate and 11% false-negative rate in a blind trial for detecting both target (mutation present) and non-target (mutation absent) DNA when gel analyzing software was used to compare Rf values after gel electrophoresis. Using the ARMS method3, a nine-sample randomized test was run that ended up with 22% false-positive rate and 19% false-negative rate from a blind trial when using a gel analyzing software to determine presence of the SNP by band intensity. Disclaimer: No DNA from human patients was used in this study. Only synthetic DNA used.

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2018-05

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Applying Arcology: Implementing Paolo Soleri's Vision into Existing Cities

Description

In this project I analyze Paolo Soleri's concept of arcology \u2014 the combination of architecture and ecology \u2014 from a theoretical, symbolic, and physical perspective. I utilize these three viewpoints to determine what aspects of his theories are most effective

In this project I analyze Paolo Soleri's concept of arcology \u2014 the combination of architecture and ecology \u2014 from a theoretical, symbolic, and physical perspective. I utilize these three viewpoints to determine what aspects of his theories are most effective for urban design. While his ideas are based on building "arcologies" from the ground up, I will be using the Phoenix Metropolitan area to determine how we could apply his ideas to existing cities without having to rebuild entirely. This past summer I participated in the 5-week construction workshop the Cosanti Foundation offers at the physical prototypical city of Arcosanti in Mayer, Arizona during which time I studied Soleri's work and participated in the construction of the city while also participating in the community dynamic there. I have found that while not all components of Soleri's theories translated well into Arcosanti, there are certainly some ideas that could be applied help to improve the City of Phoenix. I propose improvements to the pedestrian realm and an increase public space with an emphasis on utilizing the infrastructure and land that is already present for future development.

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2018-05