As average temperatures and occurrences of extreme heat events increase in the Southwest, the water infrastructure that was designed to operate under historical temperature ranges may become increasingly vulnerable to component and operational failures. For each major component along the life cycle of water in an urban water infrastructural system, potential failure events and their semi-quantitative probabilities of occurrence were estimated from interview responses of water industry professionals. These failure events were used to populate event trees to determine the potential pathways to cascading failures in the system. The probabilities of the cascading failure scenarios under future conditions were then calculated and compared to the probabilities of scenarios under current conditions to assess the increased vulnerability of the system. We find that extreme heat events can increase the vulnerability of water systems significantly and that there are ways for water infrastructure managers to proactively mitigate these vulnerabilities before problems occur.