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- Genre: Doctoral Dissertation
Description
Endocrine disruptors are chemicals that interact with the hormone system to negative effect. They ‘disrupt’ normal processes to cause diseases like vaginal cancer and obesity, reproductive issues like t-shaped uteri and infertility, and developmental abnormalities like spina bifida and cleft palate. These chemicals are ubiquitous in our daily lives, components in everything from toothpaste to microwave popcorn to plastic water bottles. My dissertation looks at the history, science, and regulation of these impactful substances in order to answer the question of how endocrine disruptors appeared, got interpreted by different groups, and what role science played in the process. My analysis reveals that endocrine disruptors followed a unique science policy trajectory in the US, rapidly going from their proposal in 1991 to their federal regulation in 1996, even amid intense and majority scientific disagreement over whether the substances existed at all. That trajectory resulted from the work of a small number of scientist-activists who constructed a concept and category as scientific, social, and regulatory. By playing actors from each sphere against each other and advancing a very specific scientific narrative that fit into a regulatory and social window of opportunity in the 1990s, those scientist-activists made endocrine disruptors a national issue that few could ignore. Those actions resulted in the Endocrine Disruptor Screening Program, a heavily-criticized and ineffective regulatory program. My dissertation tells a story of the past that informs the present. In 2018, the work of researchers, public media, and policymakers in the 1990s continues to play out, evident in the deep scientific division over endocrine disrupting effects and the inability of the European Union to settle on even a definition of endocrine disruptors for regulation purposes.
ContributorsAbboud, Alexis J (Author) / Maienschein, Jane A (Thesis advisor) / Crow, Michael M. (Committee member) / Hurlbut, J. Benjamin (Committee member) / Marchant, Gary E (Committee member) / Arizona State University (Publisher)
Created2018
Description
Scientific and Cultural Interpretations of Volcanoes, 1766-1901 analyzes nineteenth-century conceptions of volcanoes through interdisciplinary literature and science studies. The project considers how people in the nineteenth century used science, aesthetics, and other ways of knowing to understand volcanoes and their operations. In the mid-eighteenth century, volcanoes were seen as singular, unique features of the planet that lacked temporal and terrestrial reach. By the end of the nineteenth century, volcanoes were seen as networked, environmental phenomena that stretched through geological time and geographic space. Scientific and Cultural Interpretations of Volcanoes, 1766-1901 offers a new historical understanding of volcanoes and their environmental connections, using literature and science to show how perceptions of volcanic time and space changed over 135 years.
The first chapter, using texts by Sir William Hamilton, Hester Piozzi, and Priscilla Wakefield, argues that in the late eighteenth century important aspects of volcanoes, like their impact upon human life and their existence through time, were beginning to be defined in texts ranging from the scientific to the educational. The second chapter focuses on works by Sir Edward Bulwer-Lytton and Charles Lyell to demonstrate the ways that volcanoes were stripped of metaphysical or symbolic meaning as the nineteenth century progressed. The third chapter contrasts the 1883 eruption of Krakatoa with Constance Gordon-Cumming’s travels to Kīlauea. The chapter shows how even towards the end of the century, trying to connect human minds with the process of volcanic phenomenon was a substantial challenge, but that volcanoes like Kīlauea allowed for new conceptions of volcanic action. The last chapter, through a post-apocalyptic novel by M. P. Shiel, shows how volcanoes were finally beginning to be categorized as a primary agent within the environment, shaping all life including humanity. Ultimately, I argue that the change in thinking about volcanoes parallels today’s shift in thinking about global climate change. My work provides insight into how we imagine ecological catastrophes like volcanic eruptions or climate change in the past and present and what that means for their impact on people.
The first chapter, using texts by Sir William Hamilton, Hester Piozzi, and Priscilla Wakefield, argues that in the late eighteenth century important aspects of volcanoes, like their impact upon human life and their existence through time, were beginning to be defined in texts ranging from the scientific to the educational. The second chapter focuses on works by Sir Edward Bulwer-Lytton and Charles Lyell to demonstrate the ways that volcanoes were stripped of metaphysical or symbolic meaning as the nineteenth century progressed. The third chapter contrasts the 1883 eruption of Krakatoa with Constance Gordon-Cumming’s travels to Kīlauea. The chapter shows how even towards the end of the century, trying to connect human minds with the process of volcanic phenomenon was a substantial challenge, but that volcanoes like Kīlauea allowed for new conceptions of volcanic action. The last chapter, through a post-apocalyptic novel by M. P. Shiel, shows how volcanoes were finally beginning to be categorized as a primary agent within the environment, shaping all life including humanity. Ultimately, I argue that the change in thinking about volcanoes parallels today’s shift in thinking about global climate change. My work provides insight into how we imagine ecological catastrophes like volcanic eruptions or climate change in the past and present and what that means for their impact on people.
ContributorsLinthicum, Kent Robert (Author) / Lussier, Mark (Thesis advisor) / Bivona, Daniel (Committee member) / Looser, Devoney (Committee member) / Tromp, Marlene (Committee member) / Arizona State University (Publisher)
Created2016
Description
Systems biology studies complex biological systems. It is an interdisciplinary field, with biologists working with non-biologists such as computer scientists, engineers, chemists, and mathematicians to address research problems applying systems’ perspectives. How these different researchers and their disciplines differently contributed to the advancement of this field over time is a question worth examining. Did systems biology become a systems-oriented science or a biology-oriented science from 1992 to 2013?
This project utilized computational tools to analyze large data sets and interpreted the results from historical and philosophical perspectives. Tools deployed were derived from scientometrics, corpus linguistics, text-based analysis, network analysis, and GIS analysis to analyze more than 9000 articles (metadata and text) on systems biology. The application of these tools to a HPS project represents a novel approach.
The dissertation shows that systems biology has transitioned from a more mathematical, computational, and engineering-oriented discipline focusing on modeling to a more biology-oriented discipline that uses modeling as a means to address real biological problems. Also, the results show that bioengineering and medical research has increased within systems biology. This is reflected in the increase of the centrality of biology-related concepts such as cancer, over time. The dissertation also compares the development of systems biology in China with some other parts of the world, and reveals regional differences, such as a unique trajectory of systems biology in China related to a focus on traditional Chinese medicine.
This dissertation adds to the historiography of modern biology where few studies have focused on systems biology compared with the history of molecular biology and evolutionary biology.
This project utilized computational tools to analyze large data sets and interpreted the results from historical and philosophical perspectives. Tools deployed were derived from scientometrics, corpus linguistics, text-based analysis, network analysis, and GIS analysis to analyze more than 9000 articles (metadata and text) on systems biology. The application of these tools to a HPS project represents a novel approach.
The dissertation shows that systems biology has transitioned from a more mathematical, computational, and engineering-oriented discipline focusing on modeling to a more biology-oriented discipline that uses modeling as a means to address real biological problems. Also, the results show that bioengineering and medical research has increased within systems biology. This is reflected in the increase of the centrality of biology-related concepts such as cancer, over time. The dissertation also compares the development of systems biology in China with some other parts of the world, and reveals regional differences, such as a unique trajectory of systems biology in China related to a focus on traditional Chinese medicine.
This dissertation adds to the historiography of modern biology where few studies have focused on systems biology compared with the history of molecular biology and evolutionary biology.
ContributorsZou, Yawen (Author) / Laubichler, Manfred (Thesis advisor) / Maienschein, Jane (Thesis advisor) / Creath, Richard (Committee member) / Ellison, Karin (Committee member) / Newfeld, Stuart (Committee member) / Arizona State University (Publisher)
Created2016
Description
In the fifteen years between the discovery of fetal alcohol syndrome (FAS) in 1973 and the passage of alcohol beverage warning labels in 1988, FAS transformed from a medical diagnosis between practitioner and pregnant women to a broader societal risk imbued with political and cultural meaning. I examine how scientific, social, moral, and political narratives dynamically interacted to construct the risk of drinking during pregnancy and the public health response of health warning labels on alcohol. To situate such phenomena I first observe the closest regulatory precedents, the public health responses to thalidomide and cigarettes, which established a federal response to fetal risk. I then examine the history of how the US defined and responded to the social problem of alcoholism, paying particular attention to the role of women in that process. Those chapters inform my discussion of how the US reengaged with alcohol control at the federal level in the last quarter of the twentieth century. In the 1970s, FAS allowed federal agencies to carve out disciplinary authority, but robust public health measures were tempered by uncertainty surrounding issues of bureaucratic authority over labeling, and the mechanism and extent of alcohol’s impact on development. A socially conservative presidency, dramatic budgetary cuts, and increased industry funding reshaped the public health approach to alcoholism in the 1980s. The passage of labeling in 1988 required several conditions: a groundswell of other labeling initiatives that normalized the practice; the classification of other high profile, socially unacceptable alcohol-related behaviors such as drunk driving and youth drinking; and the creation of a dual public health population that faced increased medical, social, and political scrutiny, the pregnant woman and her developing fetus.
ContributorsO'Neil, Erica (Author) / Maienschein, Jane (Thesis advisor) / Hurlbut, James (Committee member) / Ellison, Karin (Committee member) / Wetmore, Jameson (Committee member) / Arizona State University (Publisher)
Created2016
Description
This dissertation begins to lay out a small slice of the history of morphological research, and how it has changed, from the late 19th through the close of the 20th century. Investigators using different methods, addressing different questions, holding different assumptions, and coming from different research fields have pursued morphological research programs, i.e. research programs that explore the process of changing form. Subsequently, the way in which investigators have pursued and understood morphology has witnessed significant changes from the 19th century to modern day research. In order to trace this shifting history of morphology, I have selected a particular organ, teeth, and traced a tendril of research on the dentition beginning in the late 19th century and ending at the year 2000. But even focusing on teeth would be impossible; the scope of research on this organ is far too vast. Instead, I narrow this dissertation to investigation of research on a particular problem: explaining mammalian tooth morphology. How researchers have investigated mammalian tooth morphology and what counts as an explanation changed dramatically during this period.
ContributorsMacCord, Katherine (Author) / Maienschein, Jane (Thesis advisor) / Laubichler, Manfred (Thesis advisor) / Laplane, Lucie (Committee member) / Kimbel, William (Committee member) / Creath, Richard (Committee member) / Hurlbut, Benjamin (Committee member) / Arizona State University (Publisher)
Created2017
Description
This dissertation examines the efforts of the Carnegie Image Tube Committee (CITC), a group created by Vannevar Bush and composed of astronomers and physicists, who sought to develop a photoelectric imaging device, generally called an image tube, to aid astronomical observations. The Carnegie Institution of Washington’s Department of Terrestrial Magnetism coordinated the CITC, but the committee included members from observatories and laboratories across the United States. The CITC, which operated from 1954 to 1976, sought to replace direct photography as the primary means of astronomical imaging.
Physicists, who gained training in electronics during World War II, led the early push for the development of image tubes in astronomy. Vannevar Bush’s concern for scientific prestige led him to form a committee to investigate image tube technology, and postwar federal funding for the sciences helped the CITC sustain development efforts for a decade. During those development years, the CITC acted as a mediator between the astronomical community and the image tube producers but failed to engage astronomers concerning various development paths, resulting in a user group without real buy-in on the final product.
After a decade of development efforts, the CITC designed an image tube, which Radio Corporation of American manufactured, and, with additional funding from the National Science Foundation, the committee distributed to observatories around the world. While excited about the potential of electronic imaging, few astronomers used the Carnegie-developed device regularly. Although the CITC’s efforts did not result in an overwhelming adoption of image tubes by the astronomical community, examining the design, funding, production, and marketing of the Carnegie image tube shows the many and varied processes through which astronomers have acquired new tools. Astronomers’ use of the Carnegie image tube to acquire useful scientific data illustrates factors that contribute to astronomers’ adoption or non-adoption of those new tools.
Physicists, who gained training in electronics during World War II, led the early push for the development of image tubes in astronomy. Vannevar Bush’s concern for scientific prestige led him to form a committee to investigate image tube technology, and postwar federal funding for the sciences helped the CITC sustain development efforts for a decade. During those development years, the CITC acted as a mediator between the astronomical community and the image tube producers but failed to engage astronomers concerning various development paths, resulting in a user group without real buy-in on the final product.
After a decade of development efforts, the CITC designed an image tube, which Radio Corporation of American manufactured, and, with additional funding from the National Science Foundation, the committee distributed to observatories around the world. While excited about the potential of electronic imaging, few astronomers used the Carnegie-developed device regularly. Although the CITC’s efforts did not result in an overwhelming adoption of image tubes by the astronomical community, examining the design, funding, production, and marketing of the Carnegie image tube shows the many and varied processes through which astronomers have acquired new tools. Astronomers’ use of the Carnegie image tube to acquire useful scientific data illustrates factors that contribute to astronomers’ adoption or non-adoption of those new tools.
ContributorsThompson, Samantha Michelle (Author) / Ellison, Karin (Thesis advisor) / Wetmore, Jameson (Thesis advisor) / Maienschein, Jane (Committee member) / Creath, Richard (Committee member) / DeVorkin, David (Committee member) / Arizona State University (Publisher)
Created2019
Description
Over the last few hundred years, best practice in some fields of human action—e.g., the treatment of heart disease, the transportation of persons, goods, and messages, and the destruction of landscapes, structures, and lives—has become dramatically more effective. At the same time, best practice in other fields, e.g., the amelioration of poverty or the teaching of reading, writing, or math, has improved more slowly, if at all. I argue that practice and technology (“know-how”) can only improve rapidly under rather special conditions: that, at any given point in time, some fields are more “progressible” than others.I articulate a conceptual framework describing several characteristics of practice in a field that may facilitate rapid progress. These characteristics, while not fixed, tend to remain fairly stable for long periods of time. I argue that know-how can improve more quickly 1) when offline “vicarious trial” of variations in practice is feasible and useful; 2) when practice is formal and standardized; 3) when practice is substantially performed by artifacts rather than by humans; 4) when outcomes of variations in practice may be rapidly evaluated; 5) when goals of practice are consistently agreed upon; 6) when contexts and objects of practice may be treated as, or have been made, consistent for the purposes of intervention; 7) when components of task systems are not heavily interdependent; and 8) when labor is finely and sharply divided.
I illustrate and elaborate this framework through comparative case studies on efforts to improve practice in three differentially “progressible” fields. I examine rapid improvement in a COVID-19 testing lab, inconsistent improvement in undergraduate algebra instruction, and ambiguous improvement in regional water modeling to support municipal water management. These cases indicate that my theory may inform judgments about the plausibility of rapid advance within a field of practice, absent disruptive change in methods or problem formulation. My theory may also shed light on which varieties of innovative effort may and may not foreseeably contribute to improving practice in a given field—more formal, theoretical, and context-independent work in high-progressibility domains, more tacit, grounded, and localized work in low-progressibility ones.
ContributorsNelson III, John Paul (Author) / Sarewitz, Daniel (Thesis advisor) / Bozeman, Barry (Committee member) / Guston, David (Committee member) / Arizona State University (Publisher)
Created2023
Description
This dissertation investigates the relationship between the universal aspirationsof technology and the particularity of place, by way of close participant observation with biotechnology companies in the San Francisco Bay Area. Its central claim is that the aspiration to placelessness in the development of science and technology operates as material configurations, modes of subjectivation, and historical conditions particular to places. Following Foucault’s late work in ethics, I conduct a series of sustained investigations into the reflective modes of critique biotechnologists make in thinking of and being in the San Francisco Bay Area. I show the ways the aspiration to placelessness exists in place at four different vantage points: the organization, the city, the broader cultural history of the region, and the practices of self-cultivation undertaken by technologists. Within biotechnology organizations, biological work is digitized and automated only through an intensification of bespoke material infrastructures, physical labor, and tacit institutional knowledge. Biotechnology organizations have come into existence through a history of settler colonial erasure, industrial devastation, post-war industrial decay, and urban renewal in Bay Area industrial suburbs and neighborhoods. A nostalgic imagination of the broader San Francisco Bay Area and its history of counterculture become mobilized as an antidote to the felt lifelessness of these forms of urban renewal and technological order and incorporated back into engineering practice. Finally, the technologist themselves must aspire to placelessness, in ways critiqued by local landless people’s movements who offer an alternative ethic to place in their imperative to gentrifiers to “move home with your parents.” I conclude by reflecting on the ways interlocutors at each of these vantage points are actively exploring the creation of more enduring relationships to place in the face of the unintended but intensified forms of social suffering in zones of technological innovation.
ContributorsHammang, Anne (Author) / Bennett, Gaymon (Thesis advisor) / Hurlbut, J. Benjamin (Committee member) / Frow, Emma (Committee member) / Arizona State University (Publisher)
Created2022
Description
At the beginning of the nineteenth century, there was no universal term to describe a person who practiced science. In 1833, the term “scientist” was proposed to recognize these individuals, but exactly who was represented by this term was still ambiguous. Supported by Bruno Latour’s theory of networks and hybridity, The Emerging Scientist takes a historical approach to analyze the different collectives of individuals who influenced the cultural perception of science and therefore aided in defining the role of the emerging scientist during the nineteenth century.
Each chapter focuses on a collective in the science network that influenced the development of the scientist across the changing scientific landscape of the nineteenth century. Through a study of William Small and Herbert Spencer, the first chapter investigates the informal clubs that prove to be highly influential due, in part, to the freedom individuals gain by being outside of formal institutions. Through an investigation of the lives and works of professional astronomer, Caroline Herschel, and physicist and mathematician, James Clerk Maxwell, chapter two analyzes the collective of professional practitioners of science to unveil the way in which scientific advancement actually occurred. Chapter three argues for the role of women in democratizing science and expanding the pool from which future scientists would come through a close analysis of Jane Marcet and Agnes Clerke, members of the collective of female popularizers of science. The final chapter examines how the collective of fictional depictions of science and the scientist ultimately are part of the cultural perception of the scientist through a close reading of Shelley’s Alastor; or, the Spirit of Solitude and Wilde’s The Picture of Dorian Gray. Ultimately, The Emerging Scientist aims to recreate the way science is studied in order to generate a more comprehensive understanding of the influences on developing science and the scientist during the nineteenth century.
Each chapter focuses on a collective in the science network that influenced the development of the scientist across the changing scientific landscape of the nineteenth century. Through a study of William Small and Herbert Spencer, the first chapter investigates the informal clubs that prove to be highly influential due, in part, to the freedom individuals gain by being outside of formal institutions. Through an investigation of the lives and works of professional astronomer, Caroline Herschel, and physicist and mathematician, James Clerk Maxwell, chapter two analyzes the collective of professional practitioners of science to unveil the way in which scientific advancement actually occurred. Chapter three argues for the role of women in democratizing science and expanding the pool from which future scientists would come through a close analysis of Jane Marcet and Agnes Clerke, members of the collective of female popularizers of science. The final chapter examines how the collective of fictional depictions of science and the scientist ultimately are part of the cultural perception of the scientist through a close reading of Shelley’s Alastor; or, the Spirit of Solitude and Wilde’s The Picture of Dorian Gray. Ultimately, The Emerging Scientist aims to recreate the way science is studied in order to generate a more comprehensive understanding of the influences on developing science and the scientist during the nineteenth century.
ContributorsSoutherly, Kaitlin (Author) / Lussier, Mark (Thesis advisor) / Broglio, Ronald (Committee member) / Bivona, Daniel (Committee member) / Arizona State University (Publisher)
Created2016
Description
This dissertation investigates how ideas of the right relationships among science, the public, and collective decision-making about science and technology come to be envisioned in constructions of public engagement. In particular, it explores how public engagement has come to be constructed in discourse around gene editing to better understand how it holds together with visions for good, democratic governance of those technologies and with what effects. Using a conceptual idiom of the co-production of science and the social order, I investigate the mutual formation of scientific expertise, responsibility, and democracy through constructions of public engagement. I begin by tracing dominant historical narratives of contemporary public engagement as a continuation of public understanding of science’s projects of social ordering for democratic society. I then analyze collections of prominent expert meetings, publications, discussions, and interventions about development, governance, and societal implications human heritable germline gene editing and gene drives that developed in tandem with commitments to public engagement around those technologies. Synthesizing the evidence from across gene editing discourse, I offer a constructive critique of constructions of public engagement as expressions and evidence of scientific responsibility as ultimately reasserting and reinforcing of scientific experts' authority in gene editing decision-making, despite intentions for public engagement to extend decision-making participation and power to publics. Such constructions of public engagement go unrecognized in gene editing discourse and thereby subtly reinforce broader visions of scientific expertise as essential to good governance by underwriting the legitimacy and authority of scientific experts to act on behalf of public interests. I further argue that the reinforcement of scientific expert authority in gene editing discourse through public engagement also centers scientific experts in a sociotechnical imaginary that I call “not for science alone.” This sociotechnical imaginary envisions scientific experts as guardians and guarantors of good, democratic governance. I then propose a possible alternatives to public engagement alone to improve gene editing governance by orienting discourse around notions of public accountability for potential shared benefits and collective harms of gene editing.
ContributorsRoss, Christian (Author) / Hurlbut, James B. (Thesis advisor) / Maienschein, Jane (Thesis advisor) / Collins, James P. (Committee member) / Crow, Michael M. (Committee member) / Sarewitz, Daniel R. (Committee member) / Arizona State University (Publisher)
Created2021