2024-03-29T05:13:12Zhttps://keep.lib.asu.edu/oai/requestoai:keep.lib.asu.edu:node-1372572021-08-11T21:09:57Zoai_pmh:all137257
https://hdl.handle.net/2286/R.I.22622
http://rightsstatements.org/vocab/InC/1.0/
2014-05
11 pages
eng
Ciambella, Michelle Lynn
Stone, Anne
Foy, Joseph
Madrigal, Lorena
Barrett, The Honors College
School of Life Sciences
Text
This project studies two single nucleotide polymorphisms (SNPs) within the HBS1L-MYB loci. Both SNPs are associated with a heightened expression of fetal hemoglobin. DNA samples of NCAA athletes who have sickle cell trait were genotyped to find the allele frequency of each SNP. When comparing all populations using information provided from the Human Genome Project on Ensembl, the minor A allele has a frequency of 22% and the major, G, allele has a frequency of 78%. The frequency distribution of the minor allele in the population data was higher than the frequency obtained from the sampled data by 15%. This means that the samples, which are heterozygous for sickle cell, display a lower frequency for the mutation than the global population.
Fetal Hemoglobin
HBS1L-MYB
Sickle Cell Anemia
HBS1L-MYB loci involvement in Fetal Hemoglobin Expression