2026-05-21T22:18:17Zhttps://keep.lib.asu.edu/oai/requestoai:keep.lib.asu.edu:node-2018422025-07-17T19:39:31Zoai_pmh:repo_items201842
https://hdl.handle.net/2286/R.2.N.201842
http://rightsstatements.org/vocab/InC/1.0/
http://creativecommons.org/licenses/by-nc-sa/4.0
2025-05
2027-06-30T05:00:00
46 pages
D'Arcy, Meaghan
Kodibagkar, Vikram
Weaver, Jessica
Barrett, The Honors College
Harrington Bioengineering Program
School of Biological & Health Systems Engineering
This research aims to develop a 3D in vitro model for measuring tissue oxygenation and
predicting its distribution. The imaging will be done using a novel MRI technique developed in
the ProBE lab, PISTOL (Proton Imaging of Siloxanes to map Tissue Oxygenation Levels). An
oxygen-sensitive 3D scaffold will simulate pO2 profiles under different conditions. The model
allows for the analysis of tissue oxygenation at hypoxic and normoxic levels to study cellular
response to varying oxygen levels. This thesis provides insight into hypoxia-related diseases
and advancements in MRI-compatible biomedical devices, with potential applications in
improving treatments for conditions like cancer and stroke.
Tissue Oxygenation
MRI
PISTOL
pO₂ mapping
Hypoxia
Cellular Response
Oxygen-sensitive
Hypoxia-related diseases
Cancer
stroke
Preparation of 3D in Vitro Models with Predictable Oxygen Distribution