2026-05-18T01:42:36Zhttps://keep.lib.asu.edu/oai/request

oai:keep.lib.asu.edu:node-2007412025-06-04T23:50:22Zoai_pmh:alloai_pmh:repo_items

200741 https://hdl.handle.net/2286/R.2.N.200741 http://rightsstatements.org/vocab/InC/1.0/ http://creativecommons.org/licenses/by-nc-sa/4.0 2025-05 33 pages Golucci, Jenna Adams, James Flynn, Christina Barrett, The Honors College School of Life Sciences The gut microbiota plays a critical role in the regulation of neurological and systemic health, with microbial metabolites serving as key mediators in this interaction. This literature review focuses on two tryptophan-derived metabolites, indoleacetic acid (IAA) and indolepropionic acid (IPA), and their levels in individuals with autism spectrum disorder (ASD). The available literature reveals a trend with some inconsistencies: IAA is elevated in six of eight studies investigating ASD, while IPA is decreased in three of four studies investigating ASD, Parkinson’s Disease, and Obesity, suggesting a disruption in the tryptophan metabolic pathway. Alterations in tryptophan metabolism may contribute to the neurodevelopmental and immunological dysregulation observed in ASD. Similar patterns of IAA and IPA dysregulation are also noted in other conditions, including Parkinson’s disease, obesity, stress responses, and pregnancy, indicating a potential contribution to a common pathophysiological mechanism mediated by the gut-brain axis. These findings support the potential utility of IAA and IPA as biomarkers for ASD and underscore their value as targets for future diagnostic and therapeutic strategies. Further investigation is warranted for both IAA and IPA in relation to ASD due to the discrepancies in findings. Autism Microbiome Indole Exploring the Role of Gut Microbiota Metabolites Indole-3-Acetic Acid and Indole-Propionic Acid in Autism Spectrum Disorder: Implications for Diagnosis and Treatment.