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200532 https://hdl.handle.net/2286/R.2.N.200532 http://rightsstatements.org/vocab/InC/1.0/ http://creativecommons.org/licenses/by-nc-sa/4.0 2025-05 17 pages Gomez, Allyiah Vernon, Brent Pizziconi, Vincent Barrett, The Honors College School of Biological & Health Systems Engineering Ulcerative colitis (UC), a chronic inflammatory bowel disease, affects millions across the globe. Patients diagnosed with this disease often carry ulcers and/or inflammation surrounding the mucosal lining of their colon and rectum areas. Current medications offer short term delivery options, however, they present many challenges such as numerous side effects, poor site targeting, and low bioavailability. With ongoing research and pre-clinical studies, pH-sensitive hydrogels are becoming increasingly recognized, as their physical and chemical properties offer promising applications for drug delivery systems aimed at treating UC. With this in mind, this literature review evaluates the design, mechanisms, and applications of pH-sensitive hydrogels for UC management, focusing on their potential to enhance treatment efficacy and patient outcomes. Ph-sensitive hydrogels Ulcerative Colitis Literature Review Stimuli Response Hydrogels with Mucosal Protection for Patients Suffering from Ulcerative Colitis - A Literature Review