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200516 https://hdl.handle.net/2286/R.2.N.200516 http://rightsstatements.org/vocab/InC/1.0/ http://creativecommons.org/licenses/by-nc-sa/4.0 2025-05 18 pages Reyes De Los Santos, Rachel Rege, Kaushal Stephanopoulos, Nicholas Klein-Seetharaman, Judith Barrett, The Honors College School of Molecular Sciences Polydimethylsiloxane (PDMS) is an elastomer used in many biomedical applications such as cosmetic implants (i.e. breast and facial), orthopedic prosthesis, bioelectronic chips and drug delivery devices (i.e. contraceptive devices). It is selected for its biocompatibility, non-biodegradation and mechanical properties. We identified a new formulation of PDMS for drug release. Choline and geranate, CAGE, ionic liquid mixed with PDMS was used to encapsulate Rhodamine B which served as our model drug for our accelerated drug release system. Ionic liquids are mixtures of organic salts or ions which are in a liquid state below 100˚C. Ionic liquids are characteristically great solvents. Thus, we postulated that an ionic liquid could help load more drug into the PDMS, aiding in the overall release. CAGE ionic liquid was selected for this experiment as it had been shown to be a successful drug delivery system for transdermal and oral/buccal delivery both for its improved release and biocompatibility. Different ratios of CAGE were homogenized with PDMS to make films and implants which were characterized by mechanical testing, tensile and Young’s modulus. The CAGE was characterized by 1H-NMR. Additionally, the release of the model drug was characterized by Korsmeyer-Peppas model to determine K values of the drug release. We achieved both high loading of the Rhodamine B and high cumulative release for an extended duration with our new formulation. Drug Release Ionic Liquid NEW FORMULATION FOR POLYDIMETHYLSILOXANE DRUG RELEASE