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200493 https://hdl.handle.net/2286/R.2.N.200493 http://rightsstatements.org/vocab/InC/1.0/ http://creativecommons.org/licenses/by-nc-sa/4.0 2025-05 45 pages Johnson, Jennifer Sterner, Beckett Sterner, Beckett Upham, Nathan Barrett, The Honors College School of Life Sciences School of Human Evolution & Social Change Department of English Microtus arvalis, the Common Vole, is a prevalent species of rodent endemic to a widespread region across Europe and Asia. The species has been cited as the reservoir host for Orthohantavirus tulaense (Tula Orthohantavirus), a species of hantavirus associated with the human disease Hemorrhagic Fever with Renal Syndrome (HFRS). This review aims to address whether M. arvalis is a spillover host for other virus species and to state the prevalence of these diseases. Papers were included based on the inclusion criteria of new empirical data on M. arvalis regarding viral detection in wild rodents. Papers were excluded in cases of missing English full text, unsatisfied inclusion criteria, and complications with data extraction. Data was extracted from 68 papers and used to create maps through Tableau to assess the relative prevalence of unique viruses by region. In total, 10,192 unique detection events of M. arvalis occurred between 1981 and 2021. Sixteen viruses were tested for in M. arvalis, with 13 belonging to the viral families Hantiviridae, Flaviviridae, Poxiviridae, Picornaviridae, Hepeviridae, and Arenaviridae. Tula Orthohantavirus received the majority of all detection efforts (5243), with 655 positive detections and an overall prevalence of 12.49%. Additionally, M. arvalis was determined to have a 3.04% prevalence for Puumala virus and a 5.43% prevalence for Dobrava-Belgrade Orthohantavirus, which are more commonly reported in Myodes glareolus and Apodemus sylvaticus, respectively. Data obtained in this review on other viral species are limited due to infrequent detection events. Additionally, due to a 2013 taxonomic revision of the M. arvalis species, studies that detect species via external morphology may be inaccurate. From the information obtained by this review, significant gaps in the current literature have been uncovered, highlighting areas for future research regarding the zoonotic virology of M. arvalis. Virus Virology Immunology Disease Zoonotic disease Epidemiology Ecology Conservation Biology A Systematic Review of the Distribution and Prevalence of Viruses Detected in Microtus arvalis