2026-05-24T12:12:21Zhttps://keep.lib.asu.edu/oai/requestoai:keep.lib.asu.edu:node-1993642025-02-20T23:16:02Zoai_pmh:alloai_pmh:repo_items199364
https://hdl.handle.net/2286/R.2.N.199364
http://rightsstatements.org/vocab/InC/1.0/
http://creativecommons.org/licenses/by-nc-sa/4.0
2024-12
12 pages
Lifshitz, Dylan
Lewis, Candace
Mennenga, Sarah
Giordano, Katherine
Barrett, The Honors College
Department of Psychology
School of International Letters and Cultures
Text
Psilocybin, a serotonergic psychedelic drug, has shown promise in treating mood disorders via neuroplastic mechanisms. This study evaluates psilocybin's effects on cognition and novelty-suppressed feeding behavior in an aging mouse model. Using behavioral assays, including Y-Maze, novelty-suppressed feeding (NSF), and marble-burying tests, we examined anxiety, depression, and cognitive function in 11- to 13-month-old mice. Results indicated sex-specific effects: psilocybin-treated females showed improved cognitive performance, but psilocybin-treated males experienced cognitive impairment. Psilocybin treatment further decreased anxiety- and depressive-like behaviors in male mice during NSF but had no significant effect in female mice. No significant treatment effects were observed in marble-burying. These findings highlight psilocybin's potential to modulate mood and cognition in aging populations, warranting further exploration into its neurobiological mechanisms and therapeutic applications.
Psilocybin
Psychedelics
Neuroscience
Mice
Aging
Cognition
Anxiety
Depression
Mental Health
Psilocybin affects cognition and novelty-suppressed feeding behavior in a mouse model of normal aging