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oai:keep.lib.asu.edu:node-1931192025-03-06T23:09:06Zoai_pmh:alloai_pmh:repo_items

193119 https://hdl.handle.net/2286/R.2.N.193119 http://rightsstatements.org/vocab/InC/1.0/ http://creativecommons.org/licenses/by-nc-sa/4.0 2024-05 47 pages Agus, Era Joy Clark, Heather Ma, Kristine Barrett, The Honors College Harrington Bioengineering Program Text This study investigates using indocyanine green (ICG) and phosphorothioate-DNA-ICG (PS-DNA-ICG) as contrast agents in photoacoustic imaging, delivered to the brain via intrathecal injection. In vitro analysis involves photoacoustic imaging of ICG in sample tubes. Ex vivo analysis involves injection of PS-DNA-ICG into a rat brain, then fixing the brain in agarose for imaging to compare the diffusion with the injection of unmodified ICG into a rat brain. Results suggest that PS-DNA-ICG can effectively serve as a contrast agent for imaging of biological tissue, demonstrating potential for use in minimally invasive, high-contrast visualization in photoacoustic imaging. This research provides insights into optimizing photoacoustic imaging techniques using a novel nano contrast agent. Photoacoustic Imaging Contrast agent In Vivo Ex Vivo In Vitro Animal Modeling Image analysis ICG Exploring Photoacoustic Imaging of Nano Contrast Agents In Vitro and Ex Vivo