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oai:keep.lib.asu.edu:node-1924682024-12-19T19:04:43Zoai_pmh:alloai_pmh:repo_items

192468 https://hdl.handle.net/2286/R.2.N.192468 http://rightsstatements.org/vocab/InC/1.0/ http://creativecommons.org/licenses/by-nc-sa/4.0 2024-05 12 pages Nguyen, Tran Andrews, Madeline Beeman, Scott Barrett, The Honors College Harrington Bioengineering Program Text In the study of brain development, culturing cells at atmospheric oxygen levels is the norm despite oxygen levels being much lower in the developing brain. Instead of culturing cells at 1-8% oxygen, the concentration of oxygen in tissues throughout the body, cell culture models are typically modeled at 20% atmospheric oxygen. My research evaluates metabolic changes in organoids cultured at 20% O2, 8% O2, and the influence of a reactive oxygen species (ROS) inhibitor, N-Acetyl-L-cysteine. Neurodevelopment Cerebral Organoids Hypoxia Exploring Effects of Varying Oxygen Levels on Neurodevelopment‬