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173845 https://hdl.handle.net/10776/1719 2007-10-30 eng Navis, Adam R. Maienschein, Jane Arizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia. Arizona Board of Regents open access http://creativecommons.org/licenses/by-nc-sa/3.0/ Epidermal growth factor is a signaling molecule that stimulates the growth of epidermal tissues during development and throughout life. Stanley Cohen discovered epidermal growth factor (EGF) during studies of nerve growth factor as a side effect of other experiments. EGF stimulates tissue growth by initiating a variety of cellular mechanisms. This work led to the 1986 Nobel Prize in Physiology or Medicine awarded to Cohen and Rita Levi-Montalcini. At the Nobel Award ceremony Levi-Montalcini focused her acceptance speech on nerve growth factor, while Cohen focused his on epidermal growth factor. Although they presented different topics, they were close collaborators and their combined effort led to the discovery of nerve growth factor. They had worked together in Viktor Hamburger's laboratory at Washington University in St. Louis. Levi-Montalcini, Rita Hamburger, Viktor, 1900-2001 Embryology Embryos Developmental Biology Epidermal Growth Factor Nerve Growth Factor Imaginal Discs Cohen, Stanley, 1937- Levi-Montalcini, Rita Hamburger, Viktor, 1900-2001 Epidermal Growth Factor