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173770 https://hdl.handle.net/10776/2316 2011-01-21 eng Jiang, Lijing Arizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia. Arizona Board of Regents open access http://creativecommons.org/licenses/by-nc-sa/3.0/ The p53 protein acts as a pivotal suppressor of inappropriate cell proliferation. By initiating suppressive effects through induction of apoptosis, cell senescence, or transient cell-cycle arrest, p53 plays an important role in cancer suppression, developmental regulation, and aging. Its discovery in 1979 was a product of research into viral etiology and the immunology of cancer. The p53 protein was first identified in a study of the role of viruses in cancer through its ability to form a complex with viral tumor antigens. In the same year, an immunological study of cancer also found p53 due to its immunoreactivity with tumor antisera. Although a series of studies found p53 through various routes, and various researchers called it different names, it was eventually confirmed that they had all encountered the same protein, p53. Tumor Suppressor Protein p53 Experiments Cancer Cell Death The Discovery of p53 Protein