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173012 https://hdl.handle.net/10776/4218 2013-03-15 eng MacCord, Kate Arizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia. Arizona Board of Regents open access http://creativecommons.org/licenses/by-nc-sa/3.0/ Between February 1969 and August 1970 Edward Kollar and Grace Baird, from the University of Chicago in Chicago, Illinois, published three papers that established the role of the mesenchyme in tooth induction. Drawing upon a history of using tissue interactions to understand differentiation, Kollar and Baird designed their experiments to understand how differentiated structures become specified. Their work overturned a widely accepted model that epithelium controls the identity of the structure, a phenomenon called structural specificity. Interactions between epithelium and mesenchyme control the development and differentiation of many parts during embryonic development, including structures like the gastrointestinal tract and hair. Thus, the realization that mesenchyme drives induction and differentiation during epithelio-mesenchymal interactions had far-reaching effects. teeth Embryos Cell differentiation Mesenchyme Epithelium Embryology Developmental Biology Cell Physiological Phenomena Cell Physiological Processes Embryonic Induction Cell Communication Experiments differentiation "The Inductive Capacity of Oral Mesenchyme and Its Role in Tooth Development" (1969-1970), by Edward J. Kollar and Grace R. Baird Kollar Baird