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172839 https://hdl.handle.net/10776/8143 2014-08-12 eng North, Jonathan Baranski, Marci Arizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia. Arizona Board of Regents open access http://creativecommons.org/licenses/by-nc-sa/3.0/ Angelman syndrome is a disorder in humans that causes neurological symptoms such as lack of speech, jerky movements, and insomnia. A human cell has two copies of twenty-three chromosomes for a total of forty-six-one copy from its mother and one from its father. But in the case of Angelman syndrome, the maternal chromosome numbered 15 has a mutation or deletion in its DNA and a gene on the paternal chromosome 15 is inactivated in some parts the brain. The result is the paternal gene is silenced during development of the sperm, which is called genetic imprinting. Angelman syndrome was one of the first disorders described as caused by genetic imprinting. Angelman syndrome Genomic imprinting Human chromosome 15--Abnormalities Human chromosome 15 Happy Puppet Syndrome Syndromes Chromosomes Neurological Disorders UBE3A protein, human Magenis, R. Ellen Angelman Syndrome