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164992 https://hdl.handle.net/2286/R.2.N.164992 http://rightsstatements.org/vocab/InC/1.0/ http://creativecommons.org/licenses/by-nc-sa/4.0 2022-05 Cook, Margaret Plaisier, Christopher Plaisier, Christopher Wilson, Melissa Barrett, The Honors College Harrington Bioengineering Program School of Molecular Sciences Text <p>An immune regulatory network was constructed for the purpose of identifying target regulators in malignant pleural mesothelioma for therapies. An identified causal flow linked a mutation of D-dopachrome tautomerase to a heightened expression of regulator ASH1L and consequent down regulation of chemokine CCL5 and invasion of CD8+ T cells. Experimental validation of this initial use case indicates mRNA expression of CCL5 within the tumor cells and subsequent protein expression and secretion. Further analyses will explore the migration of CD8+ T cells in response to the chemotactic CCL5.</p> mesothelioma Cancer immune Systems Biology Applying Regulatory Networks to the Immune Landscape of Mesothelioma