2026-05-24T21:40:46Zhttps://keep.lib.asu.edu/oai/requestoai:keep.lib.asu.edu:node-1577602024-12-20T18:25:12Zoai_pmh:alloai_pmh:repo_items157760
https://hdl.handle.net/2286/R.I.55008
http://rightsstatements.org/vocab/InC/1.0/
2019
65 pages
Masters Thesis
Academic theses
Text
eng
Stinchfield, Michael J
Newfeld, Stuart J
Capco, David
Laubichler, Manfred
Arizona State University
Masters Thesis Biology 2019
Transgenic experiments in Drosophila have proven to be a useful tool aiding in the<br/><br/>determination of mammalian protein function. A CNS specific protein, dCORL is a<br/><br/>member of the Sno/Ski family. Sno acts as a switch between Dpp/dActivin signaling.<br/><br/>dCORL is involved in Dpp and dActivin signaling, but the two homologous mCORL<br/><br/>protein functions are unknown. Conducting transgenic experiments in the adult wings,<br/><br/>and third instar larval brains using mCORL1, mCORL2 and dCORL are used to provide<br/><br/>insight into the function of these proteins. These experiments show mCORL1 has a<br/><br/>different function from mCORL2 and dCORL when expressed in Drosophila. mCORL2<br/><br/>and dCORL have functional similarities that are likely conserved. Six amino acid<br/><br/>substitutions between mCORL1 and mCORL2/dCORL may be the reason for the<br/><br/>functional difference. The evolutionary implications of this research suggest the<br/><br/>conservation of a switch between Dpp/dActivin signaling that predates the divergence of<br/><br/>arthropods and vertebrates.
Genetics
Evolution & development
Evolutionary Genetics of CORL Proteins