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oai:keep.lib.asu.edu:node-1574272024-12-20T18:25:12Zoai_pmh:alloai_pmh:repo_items

157427 https://hdl.handle.net/2286/R.I.53853 http://rightsstatements.org/vocab/InC/1.0/ 2019 44 pages Masters Thesis Academic theses Text eng Blass, Brandon Lewis Yarger, Jeff L Holland, Greg Moore, Gary Arizona State University Masters Thesis Biochemistry 2019 Generating amorphous solid dispersions (ASDs) containing active pharmaceutical ingredients has become a favorable technique of emerging prominence to improve drug solubility and overall bioavailability. Cannabidiol (CBD) has now become a major focus in cannabinoid research due to its ability to serve as an anti-inflammatory agent, showing promising results in treating a wide array of debilitating diseases and pathologies. The following work provides evidence for generating homogenous glass phase amorphous solid dispersions containing 50% (w/w) up to 75% (w/w) CBD concentrations in the domain size of 2 – 5 nm. Concentrations up to 85% (w/w) CBD were concluded homogenous in the supercooled liquid phase in domain sizes of 20 – 30 nm. The results were obtained from polarized light microscopy (PLM), differential scanning calorimetry (DSC), as well as solution and solid-state NMR spectroscopy. Biochemistry The Characterization of Cannabidiol Amorphous Solid Dispersions