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oai:keep.lib.asu.edu:node-1377742024-12-19T18:30:26Zoai_pmh:alloai_pmh:repo_items

137774 https://hdl.handle.net/2286/R.I.16831 http://rightsstatements.org/vocab/InC/1.0/ 2013-05 24 pages eng Alam, Now Bahar Sierks, Michael Pauken, Christine Williams, Stephanie Barrett, The Honors College Department of Psychology Harrington Bioengineering Program Text Misfolding and aggregation of alpha-synuclein (a-syn) has been strongly correlated with the pathogenesis of Parkinson's disease (PD). Reagents such as single chain antibody fragments (scFv) that can interact with specific aggregate forms of a-syn can be very useful to study how different aggregate forms affect cells. Here we utilize two scFvs, D5 and 10H, that recognize two distinct oligomeric forms of a-syn to characterize the presence of different a-syn aggregates in animal models of PD. Neurotoxin Cell Model of Parkinson's Disease Therapeutic Antibodies Transgenic Mice Model THY-1 Parkinson's disease Detecting Oligomeric Forms of Alpha-Synuclein in Cell and Mouse Tissue