Antibodies are naturally occurring proteins that protect a host during infection through direct neutralization and/or recruitment of the innate immune system. Unfortunately, in some infections, antibodies present unique hurdles that must be overcome for a safer and more efficacious antibody-based therapeutic (e.g., antibody dependent viral enhancement (ADE) and inflammatory pathology). This dissertation describes the utilization of plant expression systems to produce N-glycan specific antibody-based therapeutics for Dengue Virus (DENV) and Chikungunya Virus (CHIKV).
Download count: 0
- Partial requirement for: Ph.D., Arizona State University, 2019Note typethesis
- Includes bibliographical references throughout (comprehensive references pages 164- 194)Note typebibliography
- Field of study: Molecular and Cellular Biology