Validation of a Flexible Bilayer Micro-Electrocorticography Array and Extraction of High-Frequency Features of Neuronal Activity
Recordings from both layers of the flexible μECoG array showed frequency features typical of cortical local field potentials (LFP) and were shown to be stable in amplitude over time. Recordings from both layers also showed consistent, frequency-dependent modulation after induction of general anesthesia, with large increases in beta and gamma band and decreases in theta band observed over three experiments. Recordings from conventional μECoG arrays over human cortex showed robust modulation in a high frequency (250-2000 Hz) band upon production of spoken words. Modulation in this band was used to predict spoken words with over 90% accuracy. Basal Ganglia neuronal AP firing was also shown to significantly correlate with various cortical μECoG recordings in this frequency band. Results indicate that μECoG surface electrodes may detect high frequency neuronal activity potentially associated with AP firing, a source of information previously unutilized by these devices.]]>autBarton, Cody DavidthsGreger, BradleydgcGreger, BradleydgcSantello, MarcodgcBuneo, ChristopherdgcGraudejus, OliverdgcArtemiadis, PanagiotispblArizona State UniversityengDoctoral Dissertation Biomedical Engineering 2018https://hdl.handle.net/2286/R.I.5171900Doctoral DissertationAcademic theses98 pages115490262641630032421156944systemIn Copyright2018TextBioengineeringNeurosciencesaction potentialBilayer MetallizationFrequency-Domain AnalysisFunctional ConnectivityMicro-ElectrocorticographyNeural Decode