Full metadata
Title
Using Bioengineering Approaches to Generate a Three-Dimensional Human Induced Pluripotent Stem-Cell Based Model of Alzheimer's Disease
Description
The pathophysiology of Alzheimer’s disease (AD) remains difficult to precisely ascertain in part because animal models fail to fully recapitulate many aspects of the disease and postmortem studies do not allow for the study of the pathophysiology. In vitro models of AD generated with patient derived human induced pluripotent stem cells (hiPSCs) could provide new insight into disease mechanisms. Although many protocols exist to differentiate hiPSCs to neurons, standard practice relies on two-dimensional (2-D) systems, which do not accurately mimic the complexity and architecture of the in vivo brain microenvironment. This research aims to create three-dimensional (3-D) models of AD using hiPSCs, which would enhance the understanding of AD pathophysiology thereby, enabling the generation of effective therapeutics.
Date Created
2017
Contributors
- Lundeen, Rachel (Author)
- Brafman, David (Thesis advisor)
- Kiani, Samira (Committee member)
- Ebrahimkhani, Mohammad (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
49 pages
Language
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.I.44440
Level of coding
minimal
Note
Masters Thesis Bioengineering 2017
System Created
- 2017-06-07 07:44:48
System Modified
- 2021-08-26 09:47:01
- 2 years 7 months ago
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