Structural studies of the transmembrane and membrane proximal domains of HIV-1 gp41 by x-ray crystallography

Gong, Zhen

The transmembrane subunit (gp41) of the envelope glycoprotein of HIV-1 associates noncovalently with the surface subunit (gp120) and together they play essential roles in viral mucosal transmission and infection of target cells. The membrane proximal region (MPR, residues 649-683) of…

The transmembrane subunit (gp41) of the envelope glycoprotein of HIV-1 associates noncovalently with the surface subunit (gp120) and together they play essential roles in viral mucosal transmission and infection of target cells. The membrane proximal region (MPR, residues 649-683) of gp41 is highly conserved and contains epitopes of broadly neutralizing antibodies.

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Gong, Zhen (Author)
Fromme, Petra (Thesis advisor)
Mor, Tsafrir (Thesis advisor)
Ros, Alexandra (Committee member)
Redding, Kevin (Committee member)
Arizona State University (Publisher)

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2014

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Partial requirement for: Ph.D., Arizona State University, 2014

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thesis
Includes bibliographical references (p. 106-126)

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bibliography
Field of study: Chemistry

Structural studies of the transmembrane and membrane proximal domains of HIV-1 gp41 by x-ray crystallography

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