Study of ribosomes having modifications in the peptidyltransferase center using non-alpha-L-amino acids and synthesis and biological evaluation of topopyrones

The ribosome is a ribozyme and central to the biosynthesis of proteins in all organisms. It has a strong bias against non-alpha-L-amino acids, such as alpha-D-amino acids and beta-amino acids. Additionally, the ribosome is only able to incorporate one amino acid in response to one codon.